Mutagenic potential and modulatory effects of the medicinal plant Luehea divaricata (Malvaceae) in somatic cells of Drosophila melanogaster: SMART/wing

Felício, Leandro Prado; Silva, E M; Ribeiro, Vivian; Miranda, C T; Vieira, Iara Lúcia Barbosa Fernandes; Passos, Débora Cristina Silva dos; Ferreira, Alexia; Vale, Camila Regina do; Lima, D C S; Carvalho, Salvador de; Nunes, Wanderlene Blanco

doi:10.4238/vol10-1gmr982

Cited by 23 publications

(13 citation statements)

References 14 publications

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“…Extracts of L. divaricata has been shown to have antioxidant activity and analgesic property [129], lack toxicity in vivo [130], or mutagenicity [131]. Its extract also showed cytotoxicity against tumor cell lines [123].…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Bieski

Rios-Santos

Oliveira

et al. 2012

Evidence-Based Complementary and Alternative Medicine

142

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Traditional knowledge is an important source of obtaining new phytotherapeutic agents. Ethnobotanical survey of medicinal plants was conducted in Nossa Senhora Aparecida do Chumbo District (NSACD), located in Poconé, Mato Grosso, Brazil using semi-structured questionnaires and interviews. 376 species of medicinal plants belonging to 285 genera and 102 families were cited. Fabaceae (10.2%), Asteraceae (7.82%) and Lamaceae (4.89%) families are of greater importance. Species with the greater relative importance were Himatanthus obovatus (1.87), Hibiscus sabdariffa (1.87), Solidago microglossa (1.80), Strychnos pseudoquina (1.73) and Dorstenia brasiliensis, Scoparia dulcis L., and Luehea divaricata (1.50). The informant consensus factor (ICF) ranged from 0.13 to 0.78 encompassing 18 disease categories,of which 15 had ICF greater than 0.50, with a predominance of disease categories related to injuries, poisoning and certain other consequences of external causes (ICF = 0.78) having 65 species cited while 20 species were cited for mental and behavioral disorders (ICF = 0.77). The results show that knowledge about medicinal plants is evenly distributed among the population of NSACD. This population possesses medicinal plants for most disease categories, with the highest concordance for prenatal, mental/behavioral and respiratory problems.

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Section: Discussionmentioning

confidence: 99%

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Bieski

Rios-Santos

Oliveira

et al. 2012

Evidence-Based Complementary and Alternative Medicine

142

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“…The authors point out the test with aqueous extract of leaves collected in Pelotas, Southern Brazil, which showed an inhibitory effect on the germination of Lactuca sativa . Nevertheless, L. divaricata extracts demonstrate in vivo lack of toxicity or mutagenicity [69, 70]. …”

Section: Developmentmentioning

confidence: 99%

The Genus Luehea (Malvaceae-Tiliaceae): Review about Chemical and Pharmacological Aspects

Júnior

Morais

Colares

et al. 2016

Journal of Pharmaceutics

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Popularly known as “açoita-cavalo” (whips-horse), Luehea species (Malvaceae-Tilioideae) are native to America and are used in folk medicine as anti-inflammatory, antidiarrheal, antiseptic, expectorant, and depurative and against skin infections. Although there are studies showing the chemical constituents of some species, the active substances have not been properly identified. A systematic study was carried out through a computer search of data on CAPES journals, SciELO, ISI Bireme, PubMed, ScienceDirect, ScienceDomain Medline, and Google Scholar from published articles using key words: Luehea, açoita-cavalo, and Malvaceae. Luehea divaricata was the species with the highest number of studies observed. Triterpenes (9), flavonoids (6), and steroids (4), including saponins, organic acids (4), and one lignan, are the main types of secondary metabolites registered and the most cited flavonoids were rutin and quercetin and among triterpenes there was maslinic acid, which might be associated with the popular indication of its anti-inflammatory action. The vitexin, a C-glycosylated flavone, isolated from three different species, is cited as a possible taxonomic marker of the genus. Studies confirm in part the medicinal uses of plants named as “açoita-cavalo” species. Some pharmacological activities, not assigned to the species of the genus Luehea by populations, were observed in laboratory experiments.

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“…Luehea (Malvaceae) is an American genus that is distributed across Mexico to Uruguay and Argentina [7]. Species of the genus Luehea are used in popular medicine to treat fungal infections [8], dysentery, leukorrhea, gangrenous wounds, and tumors [9].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and cytotoxic activities of the extracts, fractions, and chemical constituents isolated from Luehea ochrophylla Mart

Araújo

Silva

Santos

et al. 2019

BMC Complement Altern Med

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BackgroundStem bark of Luehea ochrophylla (L. ochrophylla) is used by the traditional Brazilian medicine for treatment of rheumatic diseases and tumors. This study aimed to investigate inhibition of acute and chronic inflammations and cytotoxic activity of extracts, fractions, and isolated compounds from L. ochrophylla.MethodsHexane (HE) and ethanol (EE) extracts obtained from stem bark of L. ochrophylla were submitted to chromatographic fractionation. In order to test acute inflammation, experimental model of impact injury was used, followed by transdermal application of gels using phonophoresis. Histological analysis was based on scores assigned by the capacity of decreasing the lesion. To evaluate the effect EE and fractions on cell proliferation, human lymphocytes were stimulated with phytohemagglutinin and analyzed using flow cytometry. Proliferation was measured using VPD 450 staining and the calculated proliferative index (PI). The cytotoxic activity was evaluated using MTT colorimetric method against MDA-MB-231, MCF-7, HCT-116, and Vero cells. GraphPad Prism Version 5 was used for statistical analysis.ResultsHE and EE provided friedelin, β-friedelinol, lupeol, mixture of lupeol and pseudotaraxasterol, β-sitosterol, betulinic acid, mixture of lupeol and taraxasterol, (−)-epicatechin, β-sitosterol-3-O-β-D-glucopyranoside, and (+)-epicatechin-(4β-8)-epicatechin. HE, ethyl acetate fraction (AF), betulinic acid, and β-sitosterol promoted regeneration of muscle fibers caused by muscle injury. AF significantly (p < 0.05) reduced the lymphocyte proliferation index (1.36 for cultures stimulated with PHA, 0.7 for untreated cultures and 0.12 for cultures stimulated with PHA and treated with AF 25 μg/mL and AF 50 μg/mL, respectively). β-Sitosterol-3-O-β-D-glucopyranoside exhibited high cytotoxic activity (IC50 = 1.279 μg/mL) against HCT-116 cell line.ConclusionThese results suggest that extracts, fractions, and chemical constituents from L. ochrophylla decreases inflammatory processes generated by muscle injury. The anti-inflammatory activity may be justified by high inhibition of T cell proliferation. These extracts, fractions, and chemical constituents from L. ochrophylla may be useful as a therapeutic agent against rheumatic diseases. Moreover, chemical constituents from L. ochrophylla show potent cytotoxic activity against colon and rectal carcinomas.

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Mutagenic potential and modulatory effects of the medicinal plant Luehea divaricata (Malvaceae) in somatic cells of Drosophila melanogaster: SMART/wing

Cited by 23 publications

References 14 publications

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

The Genus Luehea (Malvaceae-Tiliaceae): Review about Chemical and Pharmacological Aspects

Anti-inflammatory and cytotoxic activities of the extracts, fractions, and chemical constituents isolated from Luehea ochrophylla Mart

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