“…None of them were rejected based on assessed quality alone, so that a large population could be obtained, based on which it is possible to draw firm conclusions. These 112 papers report on 467 patients (197 males, 238 females, and 32 not defined) from 342 unrelated families, and include 29 papers on classical EDS (cEDS; COL5A1/2 : n = 25; COL1A1 p.(Arg312Cys): n =4), 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 6 on classical-like EDS (clEDS; TNXB ), 52 , 53 , 54 , 55 , 56 , 57 three on cardiac-valvular EDS (cvEDS; COL1A2 ), 58 , 59 , 60 ten on arthrochalasia EDS (aEDS; COL1A1/2 ), 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 six on dermatosparaxis EDS (dEDS; ADAMTS2 ), 71 , 72 , 73 , 74 , 75 , 76 22 on kyphoscoliotic EDS (kEDS; PLOD1 : n = 17, FKBP14 : n = 5), 4 , 77 , ...…”