2018
DOI: 10.1182/blood-2018-99-116293
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Mutations in the Ras Pathway in Pre-Treatment Chronic Lymphocytic Leukemia Are Associated with VH1-69: Linking B-Cell Receptor Stereotypy to Downstream Signaling Events

Abstract: Introduction: Hairy cell leukemia and some other low-grade B-LPDs are characterized by a high incidence of oncogenic mutations in the Ras-MAPK pathway, most commonly in BRAF and MAP2K1 genes. In contrast, chronic lymphocytic leukemia (CLL) has a low frequency of such mutations. To determine the patterns of emergence of Ras pathway mutations in CLL, we assessed the frequency and timing of mutations in KRAS, NRAS, BRAF and MAP2K1 and their association with other CLL-associated mutations and B-cell receptor (BCR)… Show more

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