Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis

AlGabbani, Qwait

doi:10.1016/j.sjbs.2021.10.022

Cited by 8 publications

(12 citation statements)

References 48 publications

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“…PIK3CA and Yes-associated protein (Yap) can contribute to liver carcinogenesis by activating the MTORC1/2, ERK/MAPK and Notch pathways ( Li H et al, 2015 ). The risk of PIK3CA gene mutations in patients with chronic Schistosomiasis is higher, which can result in hepatocyte fibrosis and liver cancer eventually ( Algabbani, 2022 ). The polymorphisms of PIK3CA rs17849071 and rs17849079 increase the risk of HCC ( Li X et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of immunogenic cell death associated genes expression, tumor microenvironment, and prognosis in hepatocellular carcinoma

Xiang

Liu

et al. 2023

Front. Pharmacol.

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Background: Immunogenic cell death (ICD) plays an important role in the development of cancers. This study attempted to explore the role of ICD in the prognosis of hepatocellular carcinoma (HCC).Methods: Gene expression and clinical data were downloaded from The Cancer Genome Alas and Gene Expression Omnibus dataset. The immune/stromal/Estimate scores of the tumor microenvironment (TME) were calculated by ESTIMATE and CIBERSORT algorithms. Kaplan-Meier analysis, functional enrichment analysis, least absolute shrinkage and selection operator (LASSO) analysis, and univariate and multivariate Cox regression analysis were used for prognostic gene screening and prognostic model construction. The correlation of immune cell infiltration and risk scores was analyzed as well. Molecular docking was used to explore the relevance of related genes to anti-cancer drugs.Results: Ten ICD associated differentially expressed genes in HCC were found, and all of them had good predictive ability for HCC. ICD gene high amount of expression group was associated with poor prognosis (p = 0.015). The TME, immune cell infiltration and gene expression were different between ICD high and low groups (all p < 0.05). Six ICD associated genes (BAX, CASP8, IFNB1, LY96, NT5E and PIK3CA) which could predict the survival status were identified and used to construct the prognostic model for HCC. A risk score was calculated and it could be used as an independent prognostic factor in HCC patients (p < 0.001). In addition, the risk score had a positive correlation with macrophage M0 (r = 0.33, p = 0.0086). Molecular docking indicated that sorafenib could bind strongly to the target protein, representing that sorafenib may exert anticancer effects through these six ICD associated genes.Conclusion: This study established a prognostic model including six ICD associated genes for HCC, which may deepen our understanding of ICD and guide therapy for HCC patients.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of immunogenic cell death associated genes expression, tumor microenvironment, and prognosis in hepatocellular carcinoma

Xiang

Liu

et al. 2023

Front. Pharmacol.

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“…A study that evaluated the molecular mechanisms linking S. mansoni infection and HCC showed that substances released from parasite eggs in tissues trigger the permanent activation of the c-Jun and STAT3 proto-oncogenes contributing to the development of HCC [21]. Histological analysis has shown dysregulation of brosis formation in hepatocytes of patients with schistosomiasis, related to mutation of the PIK3CA and TP53 genes [13]. Changes in these genes can also be related to the development of HCC [13].…”

Section: Discussionmentioning

confidence: 99%

“…Histological analysis has shown dysregulation of brosis formation in hepatocytes of patients with schistosomiasis, related to mutation of the PIK3CA and TP53 genes [13]. Changes in these genes can also be related to the development of HCC [13].…”

Section: Discussionmentioning

confidence: 99%

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Hepatosplenic Schistosomiasis-Associated Chronic Portal Vein Thrombosis: Risk Factor for Hepatocellular Carcinoma

Darce

Makdissi

Ando

et al. 2023

Preprint

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Background: Hepatosplenic schistosomiasis is an endemic disease prevalent in tropical countries and is associated with a high incidence of portal vein thrombosis (PVT). Inflammatory changes caused by both parasitic infection and portal thrombosis can lead to the development of chronic liver disease with potential carcinogenesis. This study aimed to assess the incidence of PVT and hepatocellular carcinoma (HCC) in patients with schistosomiasis during a long-term follow-up. Methods: A retrospective study was conducted involving patients with schistosomiasis followed up at our institution between 1990 and 2021. Results: A total of 126 patients with schistosomiasis were evaluated in the study. The mean follow-up time was 16 years (range 5–31). Of the total, 73 (57.9%) patients presented PVT during the follow-up. Six (8.1%) of them were diagnosed with HCC, all of them with portal vein thrombosis diagnosed more than 10 years before. Conclusion: The incidence of HCC in patients with schistosomiasis and chronic PVT highlights the importance of a systematic long-term follow-up in this group of patients.

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“…HCC is one of the most common malignant tumors in the world, and with the continuous development of medical technology and research on the molecular biology of tumors, targeted therapy for hepatocellular carcinoma is developing rapidly [1,2]. TERT, MLL4, CCNE1, TP53, and CTNNB1 were identified as commonly mutated genes in HCC [26][27][28][29][30]. Despite the availability of many potential therapeutic targets, the incidence and mortality rates of patients with HCC are still increasing currently [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

LncRNA CARMN Affects Hepatocellular Carcinoma Prognosis by Regulating the miR-192-5p/LOXL2 Axis

Wang

Yang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Background. Hepatocellular carcinoma (HCC) is aggressive cancer with a poor prognosis. It has been suggested that the aberrant expression of LOXL2 is associated with the development of HCC, but the exact mechanism remains unclear. This research is aimed at examining the expression level and prognostic value of LOXL2 in hepatocellular carcinoma and its relationship with immune infiltration and at predicting its upstream noncoding RNAs (ncRNAs). Method. The transcriptome data of HCC was first downloaded from The Cancer Genome Atlas (TCGA) database to investigate the expression and prognosis of LOXL2. Then, the starBase database was used to find the upstream ncRNAs of LOXL2, and correlation analysis and expression analysis were performed. Finally, the Tumor Immune Estimation Resource (TIMER) was used to explore the association between LOXL2 and immune cell infiltration. Result. CARMN was considered to be the potential upstream lncRNA for the hsa-miR-192-5p/LOXL2 axis in HCC. Furthermore, the level LOXL2 was markedly positively associated with tumor immune cell infiltration and immune checkpoint expression in HCC. Conclusion. Higher expression of LOXL2 mediated by microRNA (miRNA) and long noncoding RNAs (lncRNA) is associated with poor overall survival (OS), immune infiltration, and immune checkpoint expression in HCC.

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Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis

Cited by 8 publications

References 48 publications

Comprehensive analysis of immunogenic cell death associated genes expression, tumor microenvironment, and prognosis in hepatocellular carcinoma

Comprehensive analysis of immunogenic cell death associated genes expression, tumor microenvironment, and prognosis in hepatocellular carcinoma

Hepatosplenic Schistosomiasis-Associated Chronic Portal Vein Thrombosis: Risk Factor for Hepatocellular Carcinoma

LncRNA CARMN Affects Hepatocellular Carcinoma Prognosis by Regulating the miR-192-5p/LOXL2 Axis

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