Mutual Influences between Nitric Oxide and Paraoxonase 1

Marín, Marta; Moya, Carlos J.; Máñez, Salvador

doi:10.3390/antiox8120619

Cited by 14 publications

(14 citation statements)

References 86 publications

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Section: Discussionmentioning

confidence: 99%

“…Some authors have concluded that the principal biochemical mechanisms involved in inducing OS in obesity are hyperleptinaemia, low antioxidant defences and chronic inflammation. [28][29][30][31] Therefore, obesity is not only characterized by an OS state, but it is also defined as a low-grade inflammatory disease. In agreement with this, together with the low values of the antioxidant enzymes PON1 and CAT, we found leptin values 4 times higher in morbidly obese patients than 1 year after BS, in addition to high CRP levels that were 5 times higher before BS.…”

Section: F I G U R Ementioning

confidence: 99%

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Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

Carmona-Maurici

Amigó

Cuello

et al. 2020

Eur J Clin Investigation

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Background: There is growing evidence that oxidative stress (OS) is a critical factor linking obesity with its associated comorbidities, such as cardiovascular diseases. Aim: To evaluate the degree of OS in people with morbid obesity and its relationship with glycoproteins, determined using 1H-NMR spectroscopy, before and after bariatric surgery (BS). Methods: In this observational cohort study, plasma from 24 patients with BMI ≥ 40 kg/m 2 (age: 21-65 years) was used to measure metabolites implicated in OS. We measured glycoprotein (GlycA, GlycB and GlycF) areas and shape factors (H/W = height/width). Results: One year after BS, oxidized low-density lipoprotein had decreased by 49% (P < .0001), malondialdehyde by 32% (P = .0019) and lipoprotein (a) by 21% (P = .0039). The antioxidant enzymes paraoxonase-1 and catalase increased after BS (43%, P < .0001 and 54%, P = .0002, respectively). Superoxide dismutase-2 had fallen 1 year after BS (32%, P = .0052). After BS, both the glycoprotein areas and shape factors decreased by 20%-26%. These glycoproteins were significantly correlated with OS parameters. The plasma atherogenic index was 63% higher in obese individuals than 1 year after BS and correlated positively with glycoproteins. Conclusion: For the first time, we here demonstrate the relationship between OS parameters and glycoproteins in people with morbid obesity. So glycoproteins could therefore be a good indicator, together with the oxidative state to assess patient prognosis after BS.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

Carmona-Maurici

Amigó

Cuello

et al. 2020

Eur J Clin Investigation

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“…Paraoxonase 1 (PON1) is an accessory protein of HDL which, in intimate and mutual coordination with Apolipoprotein A1 (APO A1), contributes to the lipoprotein functionality [ 14 , 15 , 16 ]. In particular, it has been widely demonstrated that PON1 protects HDL, low-density lipoprotein (LDL), endothelial cells, and intimal macrophages from oxidative insult [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Sex Difference Impacts on the Relationship between Paraoxonase-1 (PON1) and Type 2 Diabetes

et al. 2020

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Type-2 diabetes (T2D) and its cardiovascular complications are related to sex. Increasing evidence suggests that paraoxonase 1 (PON1) activity, an antioxidant enzyme bound to high-density lipoproteins (HDL), is implicated in the onset and clinical progression of T2D. Since we previously showed that PON1 is a sexual dimorphic protein, we now investigated whether sex might impact the relationship between PON1 and this chronic disease. To address this aim, we assessed PON1 activity in the sera of 778 patients, including controls (women, n = 383; men, n = 198) and diabetics (women, n = 79; men = 118). PON1 activity decreased in both women and men with T2D compared with controls (p < 0.05 and p > 0.001, respectively), but the change was 50% larger in the female cohort. In line with this result, the enzyme activity was associated with serum glucose level only in women (r = −0.160, p = 0.002). Notably, only within this gender category, lower PON1 activity was independently associated with increased odds of being diabetic (odds ratio (95% Confidence interval: 2.162 (1.075–5.678)). In conclusion, our study suggests that PON1-deficiency in T2D is a gender-specific phenomenon, with women being more affected than men. This could contribute to the partial loss of female cardiovascular advantage associated with T2D.

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“…A recent study showed that PON1 activity is modulated only by resistin, among other cytokines and adipokines evaluated (IL-6, IL-8, TNF-α, leptin, adiponectin) (40). Furthermore, it is currently accepted that high levels of peroxynitrite can 0lead to modification of PON1 activity (41). This parameter could not be evaluated in our study.…”

Section: Discussionmentioning

confidence: 76%

Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study

et al. 2021

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Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The aim of this study was to evaluate the possible association between paraoxonase-1 (PON1), periostin (POSTN), tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10 serum concentration with non-invasive liver fibrosis scores, in a cohort of patients with NAFLD. We studied a cohort of 52 patients diagnosed with NAFLD. The NAFLD fibrosis score (NFS), Fibrosis-4 Index (FIB-4), AST to platelet ratio index (APRI) and BARD scores were calculated for each patient. We determined the PON1, POSTN, TNF-α, IL-6, and IL-10 serum values using ELISA kits. There was no correlation between PON1 or POSTN serum levels and non-invasive liver fibrosis. The TNF-α serum values were independently associated with the liver fibrosis scores (P= 0.02 for NFS and P= 0.002 for FIB-4). Age and metabolic syndrome were also independently linked to the fibrosis scores. In conclusion, serum levels of TNF-α, age and metabolic syndrome were associated with the non-invasive liver fibrosis scores.

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Mutual Influences between Nitric Oxide and Paraoxonase 1

Cited by 14 publications

References 86 publications

Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

Sex Difference Impacts on the Relationship between Paraoxonase-1 (PON1) and Type 2 Diabetes

Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study

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