Mxene composite fibers with advanced thermal management for inhibiting tumor recurrence and accelerating wound healing

Ding, Yining; Xu, Lei; Chen, Shengnan; Zhu, Yong; Sun, Youhong; Ding, Liqiang; Yan, Bingyu; Ramakrishna, Seeram; Zhang, Jun; Long, Yun

doi:10.1016/j.cej.2023.141529

Cited by 21 publications

(5 citation statements)

References 36 publications

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“…MXene is easily dislodged in wounds, and direct contact with tissues may result in the persistence of MXene nanosheets in tissues, causing secondary damage injury ( Ding et al, 2023 ). Loading MXene into nanofibers helps to prevent MXene nanosheets from directly contacting the tissue.…”

Section: Application Of Mxene In the Antimicrobial Fieldmentioning

confidence: 99%

“…The adhesion, biocompatibility, and mechanical properties of the hydrogel were optimized, and the bacterial inhibition rate was greater than 95% under the synergistic effect of PTT, which had an excellent antimicrobial effect. MXene is easily dislodged in wounds, and direct contact with tissues may result in the persistence of MXene nanosheets in tissues, causing secondary damage injury (Ding et al, 2023). Loading MXene into nanofibers helps to prevent MXene nanosheets from directly contacting the tissue.…”

Section: Polymer-modified Mxenementioning

confidence: 99%

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MXene: A wonderful nanomaterial in antibacterial

Ye,

Zhang,

Lai

et al. 2024

Front. Bioeng. Biotechnol.

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Increasing bacterial infections and growing resistance to available drugs pose a serious threat to human health and the environment. Although antibiotics are crucial in fighting bacterial infections, their excessive use not only weakens our immune system but also contributes to bacterial resistance. These negative effects have caused doctors to be troubled by the clinical application of antibiotics. Facing this challenge, it is urgent to explore a new antibacterial strategy. MXene has been extensively reported in tumor therapy and biosensors due to its wonderful performance. Due to its large specific surface area, remarkable chemical stability, hydrophilicity, wide interlayer spacing, and excellent adsorption and reduction ability, it has shown wonderful potential for biopharmaceutical applications. However, there are few antimicrobial evaluations on MXene. The current antimicrobial mechanisms of MXene mainly include physical damage, induced oxidative stress, and photothermal and photodynamic therapy. In this paper, we reviewed MXene-based antimicrobial composites and discussed the application of MXene in bacterial infections to guide further research in the antimicrobial field.

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Section: Application Of Mxene In the Antimicrobial Fieldmentioning

confidence: 99%

Section: Polymer-modified Mxenementioning

confidence: 99%

MXene: A wonderful nanomaterial in antibacterial

Ye,

Zhang,

Lai

et al. 2024

Front. Bioeng. Biotechnol.

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“…As for the antibacterial activity, it was observed that the bactericidal effect could be reached up to 96.1% for E. coli and 99.1% for S. aureus. Ding et al 212 conducted a study where they incorporated Ti 3 C 2 T x MXene into PLA/GE fibers. The inclusion of MXene nanosheets in the nanofiber membrane enhanced its unidirectional thermal conductivity.…”

Section: Other Substancesmentioning

confidence: 99%

Advances in wound dressing based on electrospinning nanofibers

Zhang,

Wang,

Gao

et al. 2023

J of Applied Polymer Sci

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In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity and permeability to air and water, effective barrier properties against external pathogens, and excellent resemblance to the extracellular matrix for wound healing and skin regeneration. This article reviews the recent advancements in the application of electrospinning nanofibers for bioactive wound healing. The review begins with an overview of the wound healing process and electrospinning methods. It then explores the advantages and disadvantages of different synthetic and natural polymers used in the preparation of electrospinning wound dressings. The natural polymers discussed in this review include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, and sodium alginate. Additionally, the review delves into commonly used synthetic polymers like polyvinyl alcohol, polyvinyl chloride, polyethylene lactone, polylactide, and polyurethane for wound dressing applications. Furthermore, the review examines the blending of natural and synthetic polymers to create high‐performance wound dressings. It also explores the incorporation of functional additives, such as antimicrobial agents, growth factors, and natural extracts, into electrospinning nanofibers to expedite wound healing and tissue repair. In conclusion, electrospinning is an emerging technology that provides unique opportunities for designing more effective wound dressings and care products.

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“…However, the direct use of MXene sheets in surgical incisions may create some problems. For example, MXene nanosheets may be shed, and direct contact with tissue could potentially result in MXene nanosheets persisting in tissue that cannot be removed [ 128 ]. Loading MXene sheets into nanofibers could be helpful to avoid direct contact between MXene nanosheets and tissue.…”

Section: Biomedical Applications Of Electrospun Mxenes/polymeric Nano...mentioning

confidence: 99%

MXene-Embedded Electrospun Polymeric Nanofibers for Biomedical Applications: Recent Advances

2023

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Recently MXenes has gained immense attention as a new and exciting class of two-dimensional material. Due to their unique layered microstructure, the presence of various functional groups at the surface, earth abundance, and attractive electrical, optical, and thermal properties, MXenes are considered promising candidates for various applications such as energy, environmental, and biomedical. The ease of dispersibility and metallic conductivity of MXene render them promising candidates for use as fillers in polymer nanocomposites. MXene–polymer nanocomposites simultaneously benefit from the attractive properties of MXenes and the flexibility and facile processability of polymers. However, the potentiality of MXene to modify the electrospun nanofibers has been less studied. Understanding the interactions between polymeric nanofibers and MXenes is important to widen their role in biomedical applications. This review explores diverse methods of MXene synthesis, discusses our current knowledge of the various biological characteristics of MXene, and the synthesis of MXene incorporated polymeric nanofibers and their utilization in biomedical applications. The information discussed in this review serves to guide the future development and application of MXene–polymer nanofibers in biomedical fields.

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Mxene composite fibers with advanced thermal management for inhibiting tumor recurrence and accelerating wound healing

Cited by 21 publications

References 36 publications

MXene: A wonderful nanomaterial in antibacterial

MXene: A wonderful nanomaterial in antibacterial

Advances in wound dressing based on electrospinning nanofibers

MXene-Embedded Electrospun Polymeric Nanofibers for Biomedical Applications: Recent Advances

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