Myasthenia Gravis Immunological Relationship Between Striated Muscle and Thymus

Geld, HugoW.R. Van Der; Strauss, A

doi:10.1016/s0140-6736(66)92356-7

Cited by 103 publications

(20 citation statements)

References 11 publications

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“…We interpreted these findings as suggesting that myoid cells are an intermediate state between epithelial cells and muscular cells. Although the neural crest [15], perithymic mesenchymal cells [23], transformed thymic epithelial cells [22], and thymic stromal elements of postcapillary venules [25] have also been suggested as possible origins of myoid cells, our immunohistochemical results seem to strongly support our thymic epithelial transformation theory [22]. Thymomatous epithelial cells have also been reported to share a common epitope with skeletal muscle [5], providing further support for our theory.…”

Section: Discussionsupporting

confidence: 82%

Two cases of ectopic hamartomatous thymoma

et al. 2000

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Ectopic hamartomatous thymoma (EHT) is a rare benign neoplasm. Since it was named by Rosai et al. in 1984, 24 cases have been reported. We herein report two cases of EHT, one of which presented with massive myoid cells, and review the literature related to EHT. Both of our cases displayed the typical features of EHT: (1) nests of epithelial cells, including solid, cystic, or glandular epithelial islands; (2) spindle cells dominating the microscopic picture; and (3) adipose cells which intermingle haphazardly to impart a hamartomatous quality to the tumor. In this paper, we observed massive myoid cells and the transition from spindle epithelial cell to myoid cell in one of our cases. Immunohistochemical examinations showed that the main component of EHT, spindle cells, was positive for cytokeratin and epithelial membrane antigen (EMA). Intriguingly, the myoid cells simultaneously expressed cytokeratin, EMA, myoglobin, and creatine kinase-mm, suggesting that myoid cells may originate from epithelial cells and are an intermediate state between epithelial cells and muscular cells.

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Section: Discussionsupporting

confidence: 82%

Two cases of ectopic hamartomatous thymoma

et al. 2000

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“…An even higher (>90%) proportion of patients with MG and accompanying thymoma had such autoantibodies, which, however, could also be detected in 30% of patients with thymoma without MG (OOSTERHUIS et al 1976). Such antibodies, which react with the "A" bands of striated muscle, also apparently cross-react with thymic epithelial cells ( VAN DER GELD and STRAUSS 1966). These tentative correlations have been reinforced by the demonstration of myoid cells in the normal thymic medulla (HENRY 1966).…”

Section: Immunology Of Myasthenia Gravismentioning

confidence: 95%

Cellular Differentiation of Lymphoid Subpopulations and Their Microenvironments in the Human Thymus

Jánossy¹,

Bofill²,

Trejdosiewicz³

et al. 1986

The Human Thymus

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“…Moreover, thymectomy was shown to be beneficial in the management of some patients (9). Immunological studies on myasthenic patients have demonstrated the presence of a humoral as well as a cellular immune response towards thymic tissues in some cases (10,11), and a cytotoxic effect of myasthenic lymphocytes on cultured Abbreviations: AcChR, acetylcholine receptor; AcChE, acetylcholinesterase; MG, myasthenia gravis. * Present address: Department of Neurology, Hadassah Medical School, Jerusalem, Israel. thymus cells has also been shown (12).…”

mentioning

confidence: 99%

Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.

Aharonov¹,

Tarrab‐Hazdai²,

Abramsky³

et al. 1975

Proc. Natl. Acad. Sci. U.S.A.

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A defined immunological cross-reaction was observed between acetylcholine receptor fraction from the electric eel, Electrophorus electricus, and two calf thymus fractions. The cross-reaction was demonstrated on the cellular level by means of the lymphocyte transformation technique, and on the humoral level, by means of the microcomplement fixation assay.In the human disease myasthenia gravis both acetylcholine receptor at the neuromuscular junction and the thymus are affected, probably by an autoimmune mechanism. The immunological cross-reaction between acetylcholine receptor and thymic components may explain the association between endplate and thymus disorders in myasthenia gravis.

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Myasthenia Gravis Immunological Relationship Between Striated Muscle and Thymus

Cited by 103 publications

References 11 publications

Two cases of ectopic hamartomatous thymoma

Two cases of ectopic hamartomatous thymoma

Cellular Differentiation of Lymphoid Subpopulations and Their Microenvironments in the Human Thymus

Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.

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