Myasthenia gravis: Predictive factors associated with the synchronized elevation of anti-acetylcholine receptor antibody titer in Kanazawa, Japan

Iwasa, Kazuo; Yoshikawa, Hiroaki; Samuraki, Miharu; Shinohara, Moeko; Hamaguchi, Tetsuya; Ono, Kenjiro; Nakamura, Hiroyuki; Yamada, Masahito

doi:10.1016/j.jneuroim.2013.12.011

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…However, the AChR main immunogenic region (MIR) antibody analysis reveals that the MIR‐Ab concentration has a good correlation with MG severity (Masuda et al., 2012 ). An analysis of factors influencing elevated AChR‐Ab concentration in patients showed that patients with LOMG are more likely to have elevated antibody concentrations (Iwasa et al., 2014 ). Our overall study of patients revealed a slight correlation between the antibody concentration and age of the patient.…”

Section: Discussionmentioning

confidence: 99%

No correlation between acetylcholine receptor antibody concentration and individual clinical symptoms of myasthenia gravis: A systematic retrospective study involving 67 patients

Wang

Yang

et al. 2021

Brain and Behavior

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Section: Discussionmentioning

confidence: 99%

No correlation between acetylcholine receptor antibody concentration and individual clinical symptoms of myasthenia gravis: A systematic retrospective study involving 67 patients

Wang

Yang

et al. 2021

Brain and Behavior

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“…For example, patients with myasthenia gravis (MG) and aged <40 years have been reported to have a lower risk of autoimmune antibody (anti-acetylcholine receptor) titre elevation compared to patients aged >60 years (Iwasa et al 2014). Also, patients with early-onset MG (<40) had lower antibody elevation than patients with lateonset disease (>60).…”

Section: Autoimmune Disease Mdscs and Ageingmentioning

confidence: 99%

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Bueno

Sant’Anna

Lord

2014

AGE

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Infections, cancer and autoimmune diseases occur more frequently in the elderly, and although many factors contribute to this, the age-related remodelling of the immune system, termed immunosenescence, plays a major role. Over the last two decades, studies have evaluated the effect of ageing on both the adaptive and innate arms of the immune system and demonstrated compromised function in several cells including lymphocytes (naïve, effector and memory), regulatory T and B cells, monocytes, neutrophils and NK cells. In addition, a well-documented feature of ageing is the increase in systemic inflammatory status (inflammageing), with raised serum levels of IL6, TNFα and CRP as well as reduced IL10. Recently, myeloid-derived suppressor cells have been the focus of many reports as these cells show immunosuppressive properties and are present in higher frequency during infections, cancer and autoimmunity. Importantly, there have been publications showing increased numbers of myeloid-derived suppressor cells in aged mice and humans. In this review, we discuss the current literature on myeloid-derived suppressor cells, their possible role in altered immune function in the elderly, and whether it may be possible to manipulate these cells to alleviate age-related immune dysfunction.

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“…Recently, a work has been done over a short period of time in Japan to investigate myasthenia gravis disease predictive factors that cause the increased incidence of elevation of the titer of anti-acetylcholine receptor antibodies in patients living in Kanazawa city [25]. It has been found that patients with late-onset myasthenia gravis had a higher incidence of anti-Acetyl choline receptors antibody titer elevation compared to others with early-onset MG, and that thymus removal enabled the prevention of the increase of the antibody titer in patients with non thymoma-related myasthenia gravis [25]. These and other results further highlight the immunological involvement in this neurological disease.…”

Section: Introductionmentioning

confidence: 99%

Spotlight on Neuroimmunology: Illustrations from Neurodegenerative Diseases

Ghanemi¹,

Boubertakh²

2017

IJPHS

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<span lang="EN-US">The immune system plays key roles in the defense of the organism. However, the effects of the immune system are not limited to the immune functions and have impacts beyond the anti-pathogenes role. Indeed, neuroimmunology is a representative field of how the immune system affects non-immune biological and physio-pathological functions. Herein, we have selected a number of neurodegenerative diseases as illustrative examples to put a spotlight on this important field. Importantly, clarifying the links and interactions between the immune system and the nervous system represents key elements for the understanding neurodegenerative diseases since it will lead to new theories about the pathogenesis and the mechanisms underlying the related processes and thus, provide us with new data and novel tools to both describe the related pathways and develop new therapeutic approaches as well as diagnostic approaches and research methodologies based on such new discoveries.</span>

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Myasthenia gravis: Predictive factors associated with the synchronized elevation of anti-acetylcholine receptor antibody titer in Kanazawa, Japan

Cited by 6 publications

References 20 publications

No correlation between acetylcholine receptor antibody concentration and individual clinical symptoms of myasthenia gravis: A systematic retrospective study involving 67 patients

No correlation between acetylcholine receptor antibody concentration and individual clinical symptoms of myasthenia gravis: A systematic retrospective study involving 67 patients

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Spotlight on Neuroimmunology: Illustrations from Neurodegenerative Diseases

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