Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion

Dietlin, Therese A.; Hofman, Florence M.; Lund, Brett T.; Gilmore, Wendy; Stohlman, Stephen A.; Veen, Roel C. van der

doi:10.1189/jlb.1006640

Cited by 94 publications

(85 citation statements)

References 45 publications

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“…Mature polymorphonuclear cells were not seen in these purified preparations. The heterogeneous nature of the Gr-1 ϩ CD11b ϩ cells has been documented before in infection (19,20,51) and in cancer (2,9,74). Flow cytometric analysis using forward scatter and side scatter showed that the sorting process yielded mostly live cells (Fig.…”

Section: Cd11bsupporting

confidence: 55%

“…Murine monocytes are composed of two distinct subpopulations characterized by expression or absence of Gr-1 (32,33). Gr-1 is expressed on neutrophils, inflammatory monocytes, and some populations of dendritic cells (69), and monoclonal antibodies to Gr-1 recognize both Ly6C and Ly6G isoforms (26 (20). In infections with Trypanosoma gondii, Listeria monocytogenes, or Aspergillus fumigatus, the monocytic component is required for an effective host response (17,21,35,37,54,58,59,61,62).…”

Section: Although the Monocytic Cd11bmentioning

confidence: 99%

See 1 more Smart Citation

Phenotypic, Morphological, and Functional Heterogeneity of Splenic Immature Myeloid Cells in the Host Response to Tularemia

et al. 2012

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ABSTRACTRecent studies have linked accumulation of the Gr-1+CD11b+cell phenotype with functional immunosuppression in diverse pathological conditions, including bacterial and parasitic infections and cancer. Gr-1+CD11b+cells were the largest population of cells present in the spleens of mice infected with sublethal doses of theFrancisella tularensislive vaccine strain (LVS). In contrast, the number of T cells present in the spleens of these mice did not increase during early infection. There was a significant delay in the kinetics of accumulation of Gr-1+CD11b+cells in the spleens of B-cell-deficient mice, indicating that B cells play a role in recruitment and maintenance of this population in the spleens of mice infected withF. tularensis. The splenic Gr-1+CD11b+cells in tularemia were a heterogeneous population that could be further subdivided into monocytic (mononuclear) and granulocytic (polymorphonuclear) cells using the Ly6C and Ly6G markers and differentiated into antigen-presenting cells followingex vivoculture. Monocytic, CD11b+Ly6ChiLy6G−cells but not granulocytic, CD11b+Ly6CintLy6G+cells purified from the spleens of mice infected withF. tularensissuppressed polyclonal T-cell proliferation via a nitric oxide-dependent pathway. Although the monocytic, CD11b+Ly6ChiLy6G−cells were able to suppress the proliferation of T cells, the large presence of Gr-1+CD11b+cells in mice that survivedF. tularensisinfection also suggests a potential role for these cells in the protective host response to tularemia.

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Section: Cd11bsupporting

confidence: 55%

Section: Although the Monocytic Cd11bmentioning

confidence: 99%

Phenotypic, Morphological, and Functional Heterogeneity of Splenic Immature Myeloid Cells in the Host Response to Tularemia

et al. 2012

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“…In mycobacteria-induced experimental autoimmune encephalomyelitis models, CD11b + Gr1 + Ly-6G 2 cells are compartmentalized in spleen and prevent T cell expansion by secreting NO upon contact with Ag-activated T cells. NO-mediated suppression is counterbalanced by O 2 2 produced by neutrophils (45). These feedback mechanisms have major effects on experimental autoimmune encephalomyelitis pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium bovis Bacillus Calmette-Guérin Vaccination Mobilizes Innate Myeloid-Derived Suppressor Cells Restraining In Vivo T Cell Priming via IL-1R–Dependent Nitric Oxide Production

Martino

Badell

Abadie

et al. 2010

The Journal of Immunology

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“…The CD11b + Ly-6G + Ly-6C high cells with monocytic-like morphology are termed monocytic MDSCs (M-MDSCs), whereas the CD11b + Ly-6G + Ly-6C low cells have a granulocyte-like morphology and are termed granulocytic MDSCs (G-MDSCs) (9). These two cell groups differ in functionality: G-MDSCs frequently inhibit T cell function through arginase-1 (ARG-1) enzyme activity, whereas M-MDSCs more commonly inhibit T cell functions via nitric oxide (NO) production (10)(11)(12). Interferon (IFN)-γ-mediated activation of MDSCs results in the upregulation of ARG-1 and NO production.…”

Section: Origin and Subsets Of Mdscsmentioning

confidence: 99%

Myeloid-derived suppressor cells and myeloid regulatory cells in cancer and autoimmune disorders

Barnie

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Myeloid-derived suppressor cells (MDSCs) were originally described as a heterogeneous population of immature cells derived from myeloid progenitors with immune-suppressive functions in tumor-bearing hosts. In recent years, increasing number of studies have described various populations of myeloid cells with MDSC-like properties in murine models of cancer and autoimmune diseases. These studies have observed that the populations of MDSCs are increased during inflammation and autoimmune conditions. In addition, MDSCs can effectively suppress T cell responses and modulate the activity of natural killer cells and other myeloid cells. MDSCs have also been implicated in the induction of regulatory T cell production. Furthermore, these cells have the potential to suppress the autoimmune response, thereby limiting tissue injury. Myeloid regulatory cells (Mregs) are recently attracting increasing attention, since they function in proinflammatory and immune suppression in autoimmune diseases, as well as in various types of cancer. Currently, research focus is directed from MDSCs to Mregs in cancer and autoimmune diseases. The present study reviewed the suppressive roles of MDSCs in various autoimmune murine models, the immune modulation of MDSCs to T helper 17 lymphocytes, as well as the proinflammatory and immunosuppressive roles of Mregs in various types of cancer and autoimmune diseases.

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Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion

Cited by 94 publications

References 45 publications

Phenotypic, Morphological, and Functional Heterogeneity of Splenic Immature Myeloid Cells in the Host Response to Tularemia

Phenotypic, Morphological, and Functional Heterogeneity of Splenic Immature Myeloid Cells in the Host Response to Tularemia

Mycobacterium bovis Bacillus Calmette-Guérin Vaccination Mobilizes Innate Myeloid-Derived Suppressor Cells Restraining In Vivo T Cell Priming via IL-1R–Dependent Nitric Oxide Production

Myeloid-derived suppressor cells and myeloid regulatory cells in cancer and autoimmune disorders

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