Mycobacterium biofilms

Prevalence of Mycobacterium kansasii in clinical and environmental isolates, a systematic review and meta-analysis

“…This indicates a high prevalence of this microorganism in water samples, suggesting that water serves as a reservoir for this bacterium. Furthermore, the ability of M. kansasii to form biofilms may result in the release of this microorganism into water, posing a risk to consumers through drinking or inhalation of aerosols from showers, swimming pools, spas, and other water systems ( Muñoz-Egea et al, 2023 ). Therefore, monitoring water samples is crucial for infection control.…”

In Vitro Effect of Three-Antibiotic Combinations plus Potential Antibiofilm Agents against Biofilm-Producing Mycobacterium avium and Mycobacterium intracellulare Clinical Isolates

“…Therefore, individual antibiotics showed no activity against BF. The tolerance of BFs to antibiotics is well known and has been previously reported in the literature [ 17 , 34 ]. Biofilm acts as a physical barrier against antibiotics, resulting in a lack of correlation between in vitro susceptibility tests and treatment outcomes.…”

“…This phenomenon may occur because pulmonary drug concentrations must be much higher than serum concentrations. Drug concentrations should be higher in the lung due to the presence of secretions related to obstructive disease and the production of biofilm by mycobacteria [ 17 ], which hinders the access of the antibiotic, and the actual minimum inhibitory concentration (MIC) at the site of infection may be much higher than that detected in vitro. In biofilm-forming NTM, neither the activity of the recommended and new combinations nor the value of the most optimal MIC to treat them are known.…”

“…In biofilm-forming NTM, neither the activity of the recommended and new combinations nor the value of the most optimal MIC to treat them are known. There is scarce information about the ability of NTM to produce biofilm or its role in the persistence of infection and lack of response to treatment, although there are data suggesting that biofilm may play a relevant role [ 17 ]. The ability to form biofilm is a property of all NTMs, but the intensity of the biofilm depends on the growth conditions, such as the nutrients present in the culture medium [ 18 ].…”

“…Some studies of rapid-growth NTM have evaluated the activity of combinations of antibiotics and the use of agents with potential antibiofilm action, including detergents such as N-Acetyl-L-cysteine (NAC) or polysorbate 80, achieving synergism [ 17 ]. Ibuprofen (IBU) has been shown to have potential to inhibit biofilm development and quorum sensing (QS) in Pseudomonas aeruginosa [ 21 ].…”