Mycobacterium simiae

Abstract

The charts of twenty-four patients from whom Mycobacterium simiae was isolated from the sputum were reviewed and the patients seen in follow-up examination when possible. They were divided into 3 groups: 2 patients were felt to have had definite infection with M. simiae, 3 were felt to have had probable infection, and 19 showed no evidence of infection during follow-up for as long as 6 yr. All patients in the study had underlying pulmonary abnormalities. The results of PPD skin tests were negative in patients without evidence of tuberculosis. The patients without evidence of M. simiae infection were found to have had negative initial Acid Fast Bacillus smears, fewer sputum cultures positive for M. simiae, and lighter yields from cultures of M. simiae compared with those in the patients with M. simiae infection. We conclude that M. simiae is a nontuberculous mycobacterium capable of causing progressive granulomatous lung infection, but that it may also be identified as a causal isolate from the sputum of susceptible persons. Antituberculosis chemotherapy should not be employed in this latter group.

Clinical, Radiological, and Microbiological Characteristics of Mycobacterium simiae Infection in 97 Patients

“…To the best of our knowledge, this is the largest cohort of patients with clinical isolates of M. simiae reported in the literature to date (4,6,7,15). Reunion Island is a French overseas department located in the Indian Ocean, with a population estimated in 2016 to be more than 850,000 (Institut National de la Statistique et des Etudes Economiques, https://www.insee.fr/fr/statistiques/2018922).…”

Computed Tomography Findings of Pulmonary Mycobacterium simiae Infection

“…M. simiae is one of the rare species of NTM, first described in 1965 [7]. Up to now, M. simiae has been reported from many regions in the world but the most prevalent regions have been Southern United States and Western Asian countries [8–10]. …”

1-DE MS and 2-D LC-MS analysis of the mouse bronchoalveolar lavage proteome

“…Proteome analysis of BALF is challenging for a number of reasons, most notably the immense dynamic range of proteins present. For example, the major proteins in BALF are albumin (,50% of its total protein content), transferrin (,5.6%), a1-antitrypsin (,3.5%) and immunoglobulins A and G (,30%) [15]. One approach to decrease this dynamic range is to remove high abundance proteins with specific affinity columns; however, specifically bound ligands may also be removed with albumin and other transport proteins [16,17].…”