Mycotoxin surveillance on wheats in Shandong province, China, reveals non-negligible probabilistic health risk of chronic gastrointestinal diseases posed by deoxynivalenol

Li, Fenghua; Duan, Xinglan; Zhang, Liwen; Jiang, Dafeng; Zhao, Xianqi; Meng, En; Yi, Ran; Liu, Chang; Li, Yirui; Wang, Jiasheng; Zhao, Xiaozhen; Li, Wei; Zha, Jun

doi:10.1007/s11356-022-20812-y

Cited by 3 publications

(10 citation statements)

References 60 publications

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“…By contrast, the DON contaminations less than 100 µg/kg were found in Qingdao, Heze, Zaozhuang, Zibo, Dongying, Jining and Jinan. Of note, Jinan city as the capital city of the Shandong, maintained very low mycotoxin contamination in foods in this study and the other studies by our laboratories (Li, Duan, et al, 2022; Li, Zhao, et al, 2022). 3‐A‐DON and 15‐A‐DON were only found in the four cities of which noodle samples were heavily contaminated (Binzhou, Weihai, Linyi, and Weifang), but their amounts were considerably low.…”

Section: Resultssupporting

confidence: 74%

“…In both 2019 and 2020, Binzhou and Weihai showed EDI > 1 μg/kg/day, the value of provisional maximum tolerable daily intake by joint FAO/WHO. In our earlier study (Li, Duan, et al, 2022), Binzhou, Zibo, Liaocheng, Taian, Jinan, Heze, Dongying, Dezhou and all have EDI > 1 μg/kg/day on 2018. By applying MoE and BMDL10 approaches, and calculate the health risk of DON contamination, we found that DON contamination posed risk of adverse health effects (vomiting and diarrhea) in Binzhou and Weihai on 2019 and 2020.…”

Section: Resultsmentioning

confidence: 76%

“…For the two cities, the DON levels showed R scores with rain precipitation amounts of 0.992 and 0.542, respectively. These data have been provided in our previous publication (Li, Duan, et al, 2022).…”

Section: Discussionmentioning

confidence: 98%

“…We have previously performed mycotoxin surveillance on DON contamination in wheats from 2017 to 2019 in Shandong Province, China and showed that the local residents face nonnegligible health risks posed by DON (Li, Duan, et al, 2022). Dezhou and Binzhou cities within Shandong Province face especially high risks of liver diseases, enterogastric inflammation posed by DON.…”

Section: Introductionmentioning

confidence: 99%

“…However, public health surveillance of DON mainly focuses on preharvest examination. The data regarding the DON left in foods is less known, compared with investigation into mycotoxin contamination in raw crops (Li, Duan, et al, 2022). This has left the health risks posed by trichothecenes in the finished foods (bread, pie, noodles) obscure and insufficiently assessed.…”

Section: Introductionmentioning

confidence: 99%

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Mycotoxin monitoring in Shandong province, China reveals health risks for enterohepatic diseases shifted from environment to diet: Deoxynivalenol, zearalenone and nivalenol in noodles (2019–2020)

Duan,

Zhang,

et al. 2023

Cereal Chem

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Background and ObjectivesHigh levels of deoxynivalenol (DON) contamination in foods can raise health risks for enterohepatic diseases. Here we report our investigation into the trichothecenes (DON, 3‐acetyl‐deoxynivalenol, 15‐acetyl‐deoxynivalenol), zearalenone (ZEA) and nivalenol (NIV) showing in the wheats‐processed noodles in Shandong, China (2019–2020).FindingsThe noodles contamination status of DON in Shandong was closed to that in China in the past 10 years: 4663.9 µg/kg at maximum level, and a range of 57.9–618.8 µg/kg by mean. However, the average levels of DON measured in the noodle samples varied largely by city. Highest levels of DON contamination were found in Binzhou: 709.09 (58.8–3220) µg/kg and Weihai: 684.79 (27.6–3850) µg/kg, respectively. Besides, NIV contamination were averagely 46.99 µg/kg in Binzhou, and ZEA contamination up to 31.4 µg/kg in Weihai, pose an increasing threat of liver/intestine inflammation associated with dietary exposure.ConclusionsThe DON contamination status of noodles in Shandong was consistent with our previous investigation in wheats and in recent 10 years in China, that increased health risks for enterohepatic diseases.Significance and NoveltyTo understand the contamination situation of DON, ZEA, and NIV in noodles, so as to assess the health risks for enterohepatic diseases caused by mycotoxin in Shandong province.

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Section: Resultssupporting

confidence: 74%

Section: Resultsmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mycotoxin monitoring in Shandong province, China reveals health risks for enterohepatic diseases shifted from environment to diet: Deoxynivalenol, zearalenone and nivalenol in noodles (2019–2020)

Duan,

Zhang,

et al. 2023

Cereal Chem

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Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation

Chen,

Zhou,

et al. 2024

Journal of Hazardous Materials

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Are Infants and Children at Risk of Adverse Health Effects from Dietary Deoxynivalenol Exposure? An Integrative Review

Gonya,

Kallmerten,

Dinapoli

2024

IJERPH

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Deoxynivalenol (DON) is a foodborne mycotoxin produced by Fusarium molds that commonly infect cereal grains. It is a potent protein synthesis inhibitor that can significantly impact humans’ gastrointestinal, immune, and nervous systems and can alter the microbiome landscape. Low-dose, chronic exposure to DON has been found to stimulate the immune system, inhibit protein synthesis, and cause appetite suppression, potentially leading to growth failure in children. At higher doses, DON has been shown to cause immune suppression, nausea, vomiting, abdominal pain, headache, diarrhea, gastroenteritis, the malabsorption of nutrients, intestinal hemorrhaging, dizziness, and fever. A provisional maximum tolerable daily intake (PMTDI) limit of 1 µg/kg/body weight has been established to protect humans, underscoring the potential health risks associated with DON intake. While the adverse effects of dietary DON exposure have been established, healthcare communities have not adequately investigated or addressed this threat to child health, possibly due to the assumption that current regulatory exposure limits protect the public appropriately. This integrative review investigated whether current dietary DON exposure rates in infants and children regularly exceed PMTDI limits, placing them at risk of negative health effects. On a global scale, the routine contamination of cereal grains, bakery products, pasta, and human milk with DON could lead to intake levels above PMTDI limits. Furthermore, evidence suggests that other food commodities, such as soy, coffee, tea, dried spices, nuts, certain seed oils, animal milk, and various water reservoirs, can be intermittently contaminated, further amplifying the scope of the issue. Better mitigation strategies and global measures are needed to safeguard vulnerable youth from this harmful toxicant.

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Mycotoxin surveillance on wheats in Shandong province, China, reveals non-negligible probabilistic health risk of chronic gastrointestinal diseases posed by deoxynivalenol

Cited by 3 publications

References 60 publications

Mycotoxin monitoring in Shandong province, China reveals health risks for enterohepatic diseases shifted from environment to diet: Deoxynivalenol, zearalenone and nivalenol in noodles (2019–2020)

Mycotoxin monitoring in Shandong province, China reveals health risks for enterohepatic diseases shifted from environment to diet: Deoxynivalenol, zearalenone and nivalenol in noodles (2019–2020)

Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation

Are Infants and Children at Risk of Adverse Health Effects from Dietary Deoxynivalenol Exposure? An Integrative Review

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