Mycotoxins and Climate Change

Gomez, Karen Saez; Roldán, Elsa Castañeda; Sosa, Raul Avila; Munguía-Pérez, Ricardo

doi:10.1007/978-3-030-89664-5_14

Cited by 3 publications

(2 citation statements)

References 85 publications

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“…In certain regions of the world, mycotoxin prevalence is endemic, e.g., sub-Saharan Africa. A humid and warm climate promotes fungal growth [ 16 ]. Stress situations (e.g., drought, rises in temperature or humidity) further cause the fungi to produce mycotoxins [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Building a Human Physiologically Based Pharmacokinetic Model for Aflatoxin B1 to Simulate Interactions with Drugs

et al. 2023

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Mycotoxins such as aflatoxin B1 (AFB1) are secondary fungal metabolites present in food commodities and part of one’s daily exposure, especially in certain regions, e.g., sub-Saharan Africa. AFB1 is mostly metabolised by cytochrome P450 (CYP) enzymes, namely, CYP1A2 and CYP3A4. As a consequence of chronic exposure, it is interesting to check for interactions with drugs taken concomitantly. A physiologically based pharmacokinetic (PBPK) model was developed based on the literature and in-house-generated in vitro data to characterise the pharmacokinetics (PK) of AFB1. The substrate file was used in different populations (Chinese, North European Caucasian and Black South African), provided by SimCYP® software (v21), to evaluate the impact of populations on AFB1 PK. The model’s performance was verified against published human in vivo PK parameters, with AUC ratios and Cmax ratios being within the 0.5–2.0-fold range. Effects on AFB1 PK were observed with commonly prescribed drugs in South Africa, leading to clearance ratios of 0.54 to 4.13. The simulations revealed that CYP3A4/CYP1A2 inducer/inhibitor drugs might have an impact on AFB1 metabolism, altering exposure to carcinogenic metabolites. AFB1 did not have effects on the PK of drugs at representative exposure concentrations. Therefore, chronic AFB1 exposure is unlikely to impact the PK of drugs taken concomitantly.

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Section: Introductionmentioning

confidence: 99%

Building a Human Physiologically Based Pharmacokinetic Model for Aflatoxin B1 to Simulate Interactions with Drugs

et al. 2023

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“…In a world full of economic, health, and environmental crises, food security concerns have become one of the most important dilemmas of our era. Fungal infection and the resulting production of mycotoxins in crops are major problems caused by climate change as a result of global warming [ 1 , 2 ]. Cereals and grains are considered highly susceptible to such types of infection during the pre-harvest and post-harvest stages of their production; their availability has a vital role in preventing hunger and food insecurity [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Single, Subsequent, or Simultaneous Treatments to Mitigate Mycotoxins in Solid Foods and Feeds: A Critical Review

Dib

Assaf

Khoury

et al. 2022

Foods

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Mycotoxins in solid foods and feeds jeopardize the public health of humans and animals and cause food security issues. The inefficacy of most preventive measures to control the production of fungi in foods and feeds during the pre-harvest and post-harvest stages incited interest in the mitigation of these mycotoxins that can be conducted by the application of various chemical, physical, and/or biological treatments. These treatments are implemented separately or through a combination of two or more treatments simultaneously or subsequently. The reduction rates of the methods differ greatly, as do their effect on the organoleptic attributes, nutritional quality, and the environment. This critical review aims at summarizing the latest studies related to the mitigation of mycotoxins in solid foods and feeds. It discusses and evaluates the single and combined mycotoxin reduction treatments, compares their efficiency, elaborates on their advantages and disadvantages, and sheds light on the treated foods or feeds, as well as on their environmental impact.

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A comparative review on methods of detection and quantification of mycotoxins in solid food and feed: a focus on cereals and nuts

et al. 2023

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Mycotoxins and Climate Change

Cited by 3 publications

References 85 publications

Building a Human Physiologically Based Pharmacokinetic Model for Aflatoxin B1 to Simulate Interactions with Drugs

Building a Human Physiologically Based Pharmacokinetic Model for Aflatoxin B1 to Simulate Interactions with Drugs

Single, Subsequent, or Simultaneous Treatments to Mitigate Mycotoxins in Solid Foods and Feeds: A Critical Review

A comparative review on methods of detection and quantification of mycotoxins in solid food and feed: a focus on cereals and nuts

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