MyD88 but Not TLR2, 4 or 9 Is Essential for IL-12 Induction by Lactic Acid Bacteria

Ichikawa, Shintaro; Fujii, Ryota; Fujiwara, Daisuke; Komiyama, Yutaka; Kaisho, Tsuneyasu; Sakaguchi, Masahiro; Konishi, Yutaka

doi:10.1271/bbb.70414

Cited by 26 publications

(35 citation statements)

References 32 publications

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“…In this study, we evaluated in vivo IL-12 induction after oral administration of Lactobacillus paracasei KW3110, a strain that induces high levels of IL-12 secretion in vitro. 13) Our results indicate that KW3110 is taken up by Peyer's patch (PP) cells and induces IL-12 production in vivo.…”

mentioning

confidence: 79%

Orally AdministeredLactobacillus paracaseiKW3110 Inducesin VivoIL-12 Production

Ichikawa

Miyake

Fujii

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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mentioning

confidence: 79%

Orally AdministeredLactobacillus paracaseiKW3110 Inducesin VivoIL-12 Production

Ichikawa

Miyake

Fujii

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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“…Recent studies have revealed that bacteria, including LAB, were recognized by immune cells via some pattern-recognizing receptors [20,21]. Toll-like receptors (TLRs) are the most well-known family of pattern-recognizing receptors, and some strains of LAB have been shown to be recognized by TLR2 and TLR4 [22,23]. Immune cells produce cytokines like IL-12 after recognizing LAB, leading to Th1 skewing.…”

Section: Discussionmentioning

confidence: 99%

An Increased Number of CD4+CD25+ Cells Induced by an Oral Administration of <b><i>Lactobacillus plantarum</i></b> NRIC0380 Are Involved in Antiallergic Activity

Yoshida

Fujiwara²,

Enomoto³

et al. 2013

Int Arch Allergy Immunol

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Background: Our previous study showed that an oral administration of Lactobacillus plantarum NRIC0380 inhibited immunoglobulin E (IgE) production in a murine model, and that orally administered NRIC0380 induced CD4+CD25+ Foxp3+ T, i.e. regulatory T (Treg), cells in the spleen and Peyer's patch of mice. Although it has been reported that Treg cells might suppress the allergic symptoms, the involvement of the cells in the antiallergic activity of lactic acid bacteria has not been clearly demonstrated. We therefore examined in detail the antiallergic activity of Treg cells obtained from mice that had been fed NRIC0380. Methods: Treg cells were obtained from mice that had been fed NRIC0380. The T cell-suppressive effect of the cells was analyzed by coculturing the cells with splenocytes of β-lactoglobulin-immunized mice and β-lactoglobulin. The effects of the Treg cells on the IgE production and cutaneous anaphylaxis reaction were then analyzed by transferring the cells into another mouse. Results: The Treg cells obtained from the mice that had been fed NRIC0380 showed similar T cell-suppressive activity to those cells obtained from the control mice. The Treg cells obtained from the mice fed NRIC0380 significantly inhibited the IgE production and active cutaneous anaphylaxis reaction when transferred into another mouse that was subsequently immunized with the antigen. Furthermore, the Treg cells also significantly suppressed the passive cutaneous anaphylaxis reaction when cotransferred with the IgE antibody into another mouse. Conclusions: The induction of Treg cells by the oral administration of NRIC0380 would be involved in the antiallergic activity of NRIC0380.

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“…Note that some in vitro and in vivo effects of probiotics were found not to require TLR2, TLR4, or TLR9. 107,180,190 However, defi ciency of MyD88, an adapter molecule for TLR signaling, abolished the investigated activities. It remains to be established whether other TLRs or a MyD88-dependent, but TLR-independent, pathway is involved.…”

Section: Identifi Cation Of Active Probiotics Components and Receptormentioning

confidence: 97%

Probiotics and immunity

et al. 2009

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Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

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MyD88 but Not TLR2, 4 or 9 Is Essential for IL-12 Induction by Lactic Acid Bacteria

Cited by 26 publications

References 32 publications

Orally AdministeredLactobacillus paracaseiKW3110 Inducesin VivoIL-12 Production

Orally AdministeredLactobacillus paracaseiKW3110 Inducesin VivoIL-12 Production

An Increased Number of CD4+CD25+ Cells Induced by an Oral Administration of <b><i>Lactobacillus plantarum</i></b> NRIC0380 Are Involved in Antiallergic Activity

Probiotics and immunity

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