Mydriatic insert and intracameral injections compared with mydriatic eyedrops in cataract surgery: Controlled studies

Behndig, Anders; Korobelnik, Jean‐François

doi:10.1016/j.jcrs.2014.12.050

Cited by 24 publications

(41 citation statements)

References 116 publications

(234 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Topical mydriatic eyedrops are currently the standard method for routine pupil dilation in cats that must undergo corneal and intraocular surgeries . The main disadvantages of mydriatic eyedrops are related to delayed local effect . The delayed onset of dilation is due to the slow penetration of active ingredients through the cornea, and the time to effective dilation is longer than the cataract surgery procedure itself .…”

Section: Discussionmentioning

confidence: 99%

“…In humans, it has been shown that the intracameral administration of 0.001% epinephrine induce fast, satisfactory, and long‐lasting mydriasis to perform phacoemulsification and intraocular lens implantation . In humans, several studies have reported that the intracameral injection of 1%‐2% lidocaine provides safe and effective pupil dilation for cataract surgery . In dogs, the time to onset of mydriasis is related to both the concentration and volume of lidocaine administered in the anterior chamber .…”

Section: Discussionmentioning

confidence: 99%

“…In dogs, humans, and rabbits, no adverse ocular effects were detected after intracameral injection of preservative‐free 2% lidocaine. In humans, intracameral injection of 0.2‐0.3 mL of 1% lidocaine provides similar or even superior pupil dilation when compared to that obtained with the use of topical mydriatics .…”

Section: Introductionmentioning

confidence: 96%

“…However, intraoperative miosis is a complication that may occur in dogs and humans, resulting in inadequate equatorial lens exposure during lensectomy. Intracameral injection of 1:10 000 epinephrine and 1%‐2% lidocaine has been reported to be effective in the prevention of intraoperative miosis in dogs and humans . When injected intracamerally, lidocaine blocks the sodium channels on all nerve fibers and induces anesthesia and akinesia of the iris .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of intracameral injection of epinephrine and 2% lidocaine on pupil diameter, intraocular pressure, and cardiovascular parameters in healthy cats

Amorim

Dower

Stocco

et al. 2018

Veterinary Ophthalmology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of intracameral injection of epinephrine and 2% lidocaine on pupil diameter, intraocular pressure, and cardiovascular parameters in healthy cats

Amorim

Dower

Stocco

et al. 2018

Veterinary Ophthalmology

View full text Add to dashboard Cite

show abstract

“…6) Therefore, intraocular irrigation with 1 µg/mL adrenaline is widely used to maintain pupil dilation during surgery. [6][7][8] The irrigating solution kit consists of oxidized glutathione and its dilute solution at physiological pH and osmolality. Because the solution does not contain an antioxidant such as sodium bisulfite, the dissolved adrenaline is unstable.…”

mentioning

confidence: 99%

Stability of Adrenaline in Irrigating Solution for Intraocular Surgery

Shibata

Kimura

Taogoshi

et al. 2016

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Intraocular irrigating solution containing 1 µg/mL adrenaline is widely used during cataract surgery to maintain pupil dilation. Prepared intraocular irrigating solutions are recommended for use within 6 h. After the irrigating solution is admistered for dilution, the adrenaline may become oxidized, and this may result in a decrease in its biological activity. However, the stability of adrenaline in intraocular irrigating solution is not fully understood. The aim of this study was to evaluate the stability of adrenaline in clinically used irrigating solutions of varying pH. Six hours after mixing, the adrenaline percentages remaining were 90.6% 3.7 (pH 7.2), 91.1% 2.2 (pH 7.5), and 65.2% 2.8 (pH 8.0) of the initial concentration. One hour after mixing, the percentages remaining were 97.6% 2.0 (pH 7.2), 97.4% 2.7 (pH 7.5), and 95.6% 3.3 (pH 8.0). The degradation was especially remarkable and time dependent in the solution at pH 8.0. These results indicate that the concentration of adrenaline is decreased after preparation. Moreover, we investigated the influence of sodium bisulfite on adrenaline stability in irrigating solution. The percentage adrenaline remaining at 6 h after mixing in irrigating solution (pH 8.0) containing sodium bisulfite at 0.5 µg/mL (concentration in irrigating solution) or at 500 µg/mL (concentration in the undiluted adrenaline preparation) were 57.5 and 97.3%, respectively. Therefore, the low concentration of sodium bisulfite in the irrigating solution may be a cause of the adrenaline loss. In conclusion, intraocular irrigation solution with adrenaline should be prepared just prior to its use in surgery.

show abstract