Myeloid-derived suppressor cells in hematologic malignancies: two sides of the same coin

Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of bone marrow cells originating from immature myeloid cells. They exert potent immunosuppressive activity and are closely associated with the development of various diseases such as malignancies, infections, and inflammation. In malignant tumors, MDSCs, one of the most dominant cellular components comprising the tumor microenvironment, play a crucial role in tumor growth, drug resistance, recurrence, and immune escape. Although the role of MDSCs in solid tumors is currently being extensively studied, little is known about their role in hematologic malignancies. In this review, we comprehensively summarized and reviewed the different roles of MDSCs in hematologic malignancies and hematopoietic stem cell transplantation, and finally discussed current targeted therapeutic strategies.Affiliation: Kindly check and confirm the processed affiliations are correct. Amend if any.correct

Obesity correlates with the immunosuppressive ILC2s‐MDSCs axis in advanced breast cancer

“…12 In addition, this study also found that the ILC2s-MDSCs axis was positively correlated with PD-L1 and PD-L2. Consistently, it has been reported that the increase of ILC2s and MDSCs further promotes the increase of PD-L1, 29 leading to resistance to the immune checkpoint inhibitors. Liu et al found that MDSCs enhanced their immunosuppressive function in breast cancer by activating the PI3K/AKT signaling pathway through PD-1/PD-L1.…”

Immune cells in the B-cell lymphoma microenvironment: From basic research to clinical applications

“…[13] MDSCs can inhibit T cell function in various ways, including the production of immunosuppressive molecules such as arginase 1, inducible nitric oxide synthase, reactive oxygen species, and peroxynitrite. [13,14] Moreover, MDSCs induce differentiation and/or proliferation of Foxp3 + regulatory T cells (Tregs). [15] Studies have demonstrated that MDSCs strongly inhibit the antitumor activities of T and NK cells and stimulate Tregs, leading to tumor progression.…”

Geração in vitro de população de células supressoras mieloides a partir da diferenciação de linhagem imatura leucêmica THP1

“…(2) Brimnes et al (38) relataram pela primeira vez um aumento no número de MDSC no sangue periférico de pacientes com MM em comparação com controles saudáveis em 2010. (38,39) Mais tarde, Wang et al (40) mostraram que os níveis de M-MDSC estavam positivamente correlacionados com a recidiva do MM e negativamente correlacionados com os desfechos do tratamento. (39,40)…”

“…(38,39) Mais tarde, Wang et al (40) mostraram que os níveis de M-MDSC estavam positivamente correlacionados com a recidiva do MM e negativamente correlacionados com os desfechos do tratamento. (39,40)…”

“…(41) Além disso, o microambiente da LMA promove a expansão da população de MDSC na MO, (42) existe uma correlação positiva e relevante entre o aumento da população de MDSC e o pior prognóstico dos pacientes e a detecção de doença residual mínima está diretamente associada à presença de população de MDSC. (39,43) Maiores frequências de M-MDSC e i-MDSC foram identificadas no sangue periférico de pacientes com LMA, (39,44) e as MDSC circulantes elevadas foram significativamente correlacionados com menor remissão completa e maiores taxas de recaída e menor sobrevida a longo prazo nesses pacientes. (39,45) No entanto, mais estudos são necessários, principalmente em relação ao envolvimento das MDSC nas neoplasias hematológicas.…”