Myeloid-derived suppressor cells: key immunosuppressive regulators and therapeutic targets in hematological malignancies

Wang, Shifen; Zhao, Xingyun; Wu, Siwen; Cui, Dawei; Xu, Zhenshu

doi:10.1186/s40364-023-00475-8

Cited by 15 publications

(10 citation statements)

References 181 publications

(216 reference statements)

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“…Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cells (both monocytic and granulocytic), with potent immunosuppressive activity [31]. For instance, MDSCs may differentiate toward suppressive macrophages or neutrophils, inhibit NK cell-mediated tumor cell lysis, recruit Tregs, and prevent T cell proliferation and activation, in both solid and hematological malignancies [72][73][74].…”

Section: Myeloid-derived Suppressor Cellsmentioning

confidence: 99%

Targeting the innate immune system in pediatric and adult AML

Perzolli,

Koedijk,

Zwaan

et al. 2024

Leukemia

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While the introduction of T cell-based immunotherapies has improved outcomes in many cancer types, the development of immunotherapies for both adult and pediatric AML has been relatively slow and limited. In addition to the need to identify suitable target antigens, a better understanding of the immunosuppressive tumor microenvironment is necessary for the design of novel immunotherapy approaches. To date, most immune characterization studies in AML have focused on T cells, while innate immune lineages such as monocytes, granulocytes and natural killer (NK) cells, received less attention. In solid cancers, studies have shown that innate immune cells, such as macrophages, myeloid-derived suppressor cells and neutrophils are highly plastic and may differentiate into immunosuppressive cells depending on signals received in their microenvironment, while NK cells appear to be functionally impaired. Hence, an in-depth characterization of the innate immune compartment in the TME is urgently needed to guide the development of immunotherapeutic interventions for AML. In this review, we summarize the current knowledge on the innate immune compartment in AML, and we discuss how targeting its components may enhance T cell-based- and other immunotherapeutic approaches.

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Section: Myeloid-derived Suppressor Cellsmentioning

confidence: 99%

Targeting the innate immune system in pediatric and adult AML

Perzolli,

Koedijk,

Zwaan

et al. 2024

Leukemia

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show abstract

“…Immunosuppression refers to the inhibitory effect on the immune response, which can be attributed to immunosuppressive cells, immunosuppressive cytokines, immune checkpoints and the loss of immunogenicity of tumor cells [ 14 ]. The main immunosuppressive cells are tumor-associated macrophages (TAMs), Myeloid-Derived Suppressor Cells (MDSCs) and Regulatory T cells (Tregs) [ 13 , 179 – 181 ]. Activated macrophages have two phenotypes: the M1 phenotype that can effectively kill tumor cells and the M2 phenotype that promotes tumor growth.…”

Section: Nano-engineering In Tumor Treatmentmentioning

confidence: 99%

Nano-engineering nanomedicines with customized functions for tumor treatment applications

Wang

Ren

et al. 2023

J Nanobiotechnol

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Nano-engineering with unique “custom function” capability has shown great potential in solving technical difficulties of nanomaterials in tumor treatment. Through tuning the size and surface properties controllablly, nanoparticles can be endoewd with tailored structure, and then the characteristic functions to improve the therapeutic effect of nanomedicines. Based on nano-engineering, many have been carried out to advance nano-engineering nanomedicine. In this review, the main research related to cancer therapy attached to the development of nanoengineering nanomedicines has been presented as follows. Firstly, therapeutic agents that target to tumor area can exert the therapeutic effect effectively. Secondly, drug resistance of tumor cells can be overcome to enhance the efficacy. Thirdly, remodeling the immunosuppressive microenvironment makes the therapeutic agents work with the autoimmune system to eliminate the primary tumor and then prevent tumor recurrence and metastasis. Finally, the development prospects of nano-engineering nanomedicine are also outlined.

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“…CAFs also contribute to the immunosuppressive nature of the TME, recruiting regulatory T cells (Tregs) via CCL2 secretion ( 83 ). Similarly, Myeloid-Derived Suppressor Cells (MDSCs) are essential players in dampening the anti-tumor immune response, inhibiting T cell activation with reactive species, and depleting crucial amino acids, which further impede T cell functionality ( 95 ).…”

Section: Tam Interactions and Polarization Dynamicsmentioning

confidence: 99%

Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs

Shao,

Miao,

2023

Front. Immunol.

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Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit unparalleled adaptability, aligning with the dynamic tumor milieu. Their roles span from promoting tumor growth and angiogenesis to modulating metastasis. While substantial research has explored the fundamentals of TAMs, comprehending their adaptive behavior, and leveraging it for novel treatments remains challenging. This review delves into TAM polarization, metabolic shifts, and the complex orchestration of cytokines and chemokines determining their functions. We highlight the complexities of TAM-targeted research focusing on their adaptability and potential variability in therapeutic outcomes. Moreover, we discuss the synergy of integrating TAM-focused strategies with established cancer treatments, such as chemotherapy, and immunotherapy. Emphasis is laid on pioneering methods like TAM reprogramming for cancer immunotherapy and the adoption of single-cell technologies for precision intervention. This synthesis seeks to shed light on TAMs’ multifaceted roles in cancer, pinpointing prospective pathways for transformative research and enhancing therapeutic modalities in oncology.

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Myeloid-derived suppressor cells: key immunosuppressive regulators and therapeutic targets in hematological malignancies

Cited by 15 publications

References 181 publications

Targeting the innate immune system in pediatric and adult AML

Targeting the innate immune system in pediatric and adult AML

Nano-engineering nanomedicines with customized functions for tumor treatment applications

Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs

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