“…On the other side, the AhR‐dependent signalling pathway is connected with other signalling pathways such as the antioxidant response by Nrf2 . Further on, the AhR interacts with several cytokines and growth factors including the epidermal growth factor depending signalling, TNF‐α and TGF‐β, and finally, the AhR is expressed also in immunocompetent cells such as antigen‐presenting monocytes or macrophages as well as T lymphocytes, in particular in Th17‐cells . Therefore, it ruled out that the AhR functions on the one side as a sensor not only for multiple exogenous chemical agents but also for UV light and the microbiome; on the other side, this receptor influences in the target organs such as the skin multiple physiological and pathophysiological processes, e.g.…”