Myeloid sarcoma presenting as bilateral acute otitis externa in newly diagnosed acute myeloid leukemia

Chen, Sarah M.; Silverman, Dustin A.; Jatana, Kris R.; Chiang, Tendy; Guinipero, Terri; Hill, N.; Siu, Jason J.; Reed, Suzanne

doi:10.1016/j.ijporl.2019.04.002

Cited by 4 publications

(7 citation statements)

References 19 publications

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“…However, it is often difficult to establish the histopathological diagnosis of leukemic etiology in otological diseases. In fact, it is common to have either insufficient material or significant artefacts in the biopsy specimens [7,14,15]. Histopathology, therefore, is not always satisfactory for the complete identification of the lesion, and can lead to misdiagnosis, even in well-differentiated tumors [15].…”

Section: Discussionmentioning

confidence: 99%

“…Head and neck involvement is uncommon. However, cases of ocular, nasopharynx and central nervous system MS have been reported [7]. As for the ear involvement, it has been rarely reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…The overall incidence is estimated at 2.5 to 9.1% among AML patients, with a slight predilection among male individuals. It may be seen at any age, but the highest incidence occurs in pediatric patients [6,7]. In general, the presence of MS in patients with AML, myelodysplasia or myeloproliferative syndromes carries an unfavorable overall prognosis [13].…”

Section: Discussionmentioning

confidence: 99%

“…This plethora of possible symptoms and differential diagnoses make the recognition of MS challenging. Bilateral MS has been described by Chen, et al [7] and might pose particular diagnostic difficulties [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…The myeloid sarcoma (MS) is a rare disease in which one or more tumors of myeloid progenitor cells occur in extramedullary location [3,6]. The MS might affect the ear in a few cases, and mimic other diseases [3,7,8].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Myeloid Sarcoma in the Ear Followed by Labirinthine Hemorrhage: A Rare Presentation of Late Relapse in Acute Myeloid Leukemia

Lucinda¹,

Tássia²,

Toledo³

et al. 2022

Otolaryngol Res Rev

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Myeloid sarcoma (MS) is an immature myeloid cells tumor that might occur in acute myeloid leukemia (AML) even without bone marrow involvement. We present a rare case of an 18-year-old teenager who developed MS in the external auditory canal (EAC), and subsequent inner ear impairment, as the first manifestation of recurrence of promyelocytic AML. High suspicion and early identification are paramount in terms of overall prognosis of the underlying condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Myeloid Sarcoma in the Ear Followed by Labirinthine Hemorrhage: A Rare Presentation of Late Relapse in Acute Myeloid Leukemia

Lucinda¹,

Tássia²,

Toledo³

et al. 2022

Otolaryngol Res Rev

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Granulocytic Sarcoma Mimicking Cholesteatoma: Beware the Temporal Bone in Haematological Patients

Mayani-Mayani,

González-Arnay,

Acosta-Criado

et al. 2023

ORL

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Granulocytic sarcoma is a myeloid neoplasm that can occur in isolation or in association with acute leukaemia. The temporal bone represents a sanctuary site for myeloid progenitors: granulocytic sarcoma may develop in this location before or concomitantly with the onset of acute leukaemia. This atypical presentation with clinical and radiological data that closely mimic those of cholesteatoma often delays an accurate diagnosis. We here describe the clinical case of a 28-year-old male with granulocytic sarcoma of the external auditory canal that preceded the relapse of promyelocytic leukaemia.

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Temporal Bone Myeloid Sarcoma Presenting as Necrotizing Otitis Externa: A Case Report and Literature Review

Nayouf,

Alahmad,

Laflouf

et al. 2024

Ear Nose Throat J

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Myeloid sarcoma (MS) is a proliferation of immature myeloid cells that occurs extramedullary, often accompanying acute myeloid leukemia (AML). It typically presents in areas such as lymph nodes, skin, and the head and neck regions. The emergence of MS within the temporal bone is rare, and it can manifest through nonspecific symptoms. In this paper, we reported a case of A 47-year-old female presented with right-sided otalgia, otorrhea, tinnitus, reduced hearing, and ear fullness, and developed facial asymmetry. She was initially diagnosed with necrotizing otitis externa and was treated accordingly. Further investigations were conducted, leading to the diagnosis of MS. She began treatment with induction chemotherapy followed by consolidation therapy. And we reviewed the literature and included 14 MS cases with the same anatomical localization, discussing the primary presentation, immunohistochemistry, and treatment approaches of these patients. In conclusion, temporal bone MS should be considered in patients with a history of AML presenting with nonspecific symptoms. Diagnostic modalities for MS include computed tomography and magnetic resonance imaging scans. Systemic chemotherapy remains the preferred treatment approach. The complexity and diversity of temporal bone MS presentations necessitate further comprehensive research to enhance understanding and improve management strategies for this rare condition.

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Myeloid sarcoma presenting as bilateral acute otitis externa in newly diagnosed acute myeloid leukemia

Cited by 4 publications

References 19 publications

Myeloid Sarcoma in the Ear Followed by Labirinthine Hemorrhage: A Rare Presentation of Late Relapse in Acute Myeloid Leukemia

Myeloid Sarcoma in the Ear Followed by Labirinthine Hemorrhage: A Rare Presentation of Late Relapse in Acute Myeloid Leukemia

Granulocytic Sarcoma Mimicking Cholesteatoma: Beware the Temporal Bone in Haematological Patients

Temporal Bone Myeloid Sarcoma Presenting as Necrotizing Otitis Externa: A Case Report and Literature Review

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