Myeloperoxidase, a possible biomarker for the early diagnosis of cardiac diastolic dysfunction with preserved ejection fraction

Abstract

The current study was conducted on a sample of 91 patients diagnosed with diastolic dysfunction (DD) with preserved systolic function caused by a painful chronic ischaemic cardiopathy – angina pectoris stable at the effort. The diagnosis was established following anamnesis, electrocardiogram, and echocardiography. Myeloperoxidase (MPO) serum levels were assessed in all patients and then these values were correlated with some of the echocardiography parameters that proved the mentioned diagnosis.In conclusion, the execution of this investigation triad (electrocardiogram, echocardiography, and MPO) allows:Stratifying the patients depending on the disease risk by early detecting of any possible DD with preserved systolic function.The use of the MPO increased circulating levels as a biomarker for diagnosis and risk due to the statistically significant correlation between those and the results of the other two aforementioned paraclinical investigation.

Osteopontin – a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease

“…The above-mentioned activated paths allow the intervention of the matrix OPN whose synthesis is stimulated by the angiotensin II (Ang II)–aldosterone system to intervene in the development of myocardial remodelling and fibrosis 2 , 4 , 5 . Regulation at the myocardial level of these two processes is the synergistic action of OPN and Ang II, via the activation of the inflammatory process 1–4 , 11 , 12 . Besides, there are also the modulations of the apoptosis process and the facilitating of the survival of cardiomyocytes, the result of which is the installation of an inotropic function deficit 13 , 14 .…”

Anti-inflammatory and hepatoprotective effects of polyherbal composition in patients with chronic cholecystitis

“…In such cases, generated oxidants have significant potential to damage host tissue and are associated with many inflammatory diseases [22]. Currently, the level of circulating MPO is considered as an informative diagnostic and prognostic biomarker of pathological states associated with acute or chronic inflammation [23]. In our study, baseline total MPO level in blood plasma of patients with chronic cholecystitis was significantly higher than that in healthy persons, especially in male patients ( Table 5).…”

Nitrous Oxide - a Viable and Modern Alternative for Inhalation Analgesia in Labor

“…Nitrous oxide causes a minimal decrease in respiratory volume, but this does not have a real impact on lung function, due to the slightly increased of respiratory rate, so that partial pressure PCO 2 is maintained at normal levels. In patients without associated pathology, changes in the cardiovascular system are apparently minimal because nitrous oxide has sympathomimetic activity that balances the myocardial decompensation effect that is common in left ventricular dysfunction with preserved ejection fraction [8,9]. It is should not be used in patients with severe heart failure, as this would lead to a significant decrease in heart rate, assessed by specific and non-specific biomarkers [10,11].…”