2023
DOI: 10.1111/bjh.19102
|View full text |Cite
|
Sign up to set email alerts
|

Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma

Connor M. D. Williams,
Jacqueline E. Noll,
Alanah L. Bradey
et al.

Abstract: SummaryExpression of myeloperoxidase (MPO), a key inflammatory enzyme restricted to myeloid cells, is negatively associated with the development of solid tumours. Activated myeloid cell populations are increased in multiple myeloma (MM); however, the functional consequences of myeloid‐derived MPO within the myeloma microenvironment are unknown. Here, the role of MPO in MM pathogenesis was investigated, and the capacity for pharmacological inhibition of MPO to impede MM progression was evaluated. In the 5TGM1‐K… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 61 publications
0
1
0
Order By: Relevance
“…Imaging modalities have been developed for years to diagnose inflammation-related diseases in preclinical and clinical studies. For instance, bioluminescence imaging of inflammation is facilitated by the reaction of luminol with myeloperoxidase (MPO) in inflamed regions 33 . Additionally, ultrasound (US) can measure plaque inflammation by evaluating enhanced permeability and neovascularization using non-targeted microbubbles.…”
Section: Introductionmentioning
confidence: 99%
“…Imaging modalities have been developed for years to diagnose inflammation-related diseases in preclinical and clinical studies. For instance, bioluminescence imaging of inflammation is facilitated by the reaction of luminol with myeloperoxidase (MPO) in inflamed regions 33 . Additionally, ultrasound (US) can measure plaque inflammation by evaluating enhanced permeability and neovascularization using non-targeted microbubbles.…”
Section: Introductionmentioning
confidence: 99%