Myeloperoxidase Polymorphism Is Associated with Gender Specific Risk for Alzheimer's Disease

Gender and smoking-related risk reduction of periodontal disease with variant myeloperoxidase alleles

“…This observation appears sex-specific as this association could not be observed among male subjects. It is most intriguing that these results are corresponding to the associations reported for different diseases such as lung cancer, [12][13][14] esophageal cancer, 15 coronary artery disease, 16 Helicobacter pylori infections 17 and neuro-degenerative disorders, ie Alzheimer's disease 18 and multiple sclerosis. 19 In all these studies, the allelic variant MPO −463A elicited a protective effect with nearly identical odds ratios in the range of 0.3-0.7.…”

“…19 In all these studies, the allelic variant MPO −463A elicited a protective effect with nearly identical odds ratios in the range of 0.3-0.7. In some of these studies gender-specific results were presented showing the protective effect of the MPO A-allele either only in females 18,19 or only in males. 17 There must be a common link leading to this correspondence in the different clinical settings.…”

A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection

“…This phenomenon has also been observed in resident brain macrophage-microglia surrounding Alzheimer's plaques. 15 In addition to direct damage of hepatocytes, macrophage-generated oxidants are thought to stimulate production of extracellular matrix by Kupffer cells in the liver. 8 These hypotheses all assume that higher MPO expression leads to more fibrosis, which seems likely based on the ability of MPO to generate hypochlorous acid and other reactive oxidizing species.…”

“…31 A number of studies now suggest that MPO genotype is differentially associated with various disease states. The GG genotype has been associated with increased incidence of myeloid leukemia, 13 multiple sclerosis (females), 20 Alzheimer's disease (females), 15 lung cancer 17 (males), 26 aerodigestive tract cancers, 21,22 and gastrointestinal complications in chronic granulomatous disease, 25 while the GA/AA genotypes have been associated with increased risk in aging Finnish males for Alzheimer's disease 12 and lung cancer. 19 The latter examples suggest that the A allele may be the higher expressing allele in certain inflammatory conditions, due to particular cytokines or transcription factors, such as estrogen receptor, or due to myeloid cell types involved, such as macrophage versus neutrophil or monocyte.…”

“…13 Recent studies show MPO genotype to be associated with increased risk for a variety of inflammatory and autoimmune conditions. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] This suggests the local cellular expression of MPO may play a role in the pathogenesis of different disease states. In the present study, we investigated the relationship between the MPO promoter polymorphism and liver fibrosis in patients with chronic (HCV) hepatitis.…”