Myeloperoxydase activity in the pathogenesis of cholesteatoma

Çelebi, Özlem Önerci; Paksoy, Mustafa; Aydın, Sedat; Şanlı, Arif; Taşdemir, Ömer; Gül, Aylin

doi:10.1007/s12070-010-0011-y

Cited by 4 publications

(6 citation statements)

References 16 publications

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“…In agreement with this notion, studies have documented that high-level production of MPO is detected in many inflammatory diseases, such as infection, ischemia, atherosclerosis and acute myeloid leukemia. [11][12][13][14] Consistently, clinical data have also shown that MPO exists in abundance in middle-ear lavage fluid (MELF) 15 and middle ear mucosa 16 of patients with AOM. However, the precise role of MPO in pneumococcal AOM is still poorly characterized.…”

Section: Introductionmentioning

confidence: 63%

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The critical role of myeloperoxidase in Streptococcus pneumoniae clearance and tissue damage during mouse acute otitis media

et al. 2017

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We have recently reported that neutrophils play a pivotal role in innate defense against Streptococcus pneumoniae ( Spn) during mouse acute otitis media (AOM). However, the underlying mechanism remains unclear. By constructing models of pneumococcal AOM in C57BL/6 mice and using a specific inhibitor in vivo, we investigated the role of myeloperoxidase (MPO), one of the most important protein components of neutrophils. Experiment results showed a significant increase in MPO production of the recruited neutrophils in Spn-infected mice. Neutrophils killed Spn in a MPO-dependent manner. MPO facilitated the generation of reactive oxygen species (ROS), and consequently promoted Spn clearance at an early stage and exacerbated tissue damage. Moreover, MPO induced neutrophil apoptosis and necrosis, which, in turn, worsened tissue damage. In summary, our study demonstrates that neutrophil MPO plays a paradoxical role in bacterial clearance and tissue damage in pneumococcal AOM.

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Section: Introductionmentioning

confidence: 63%

“…11 Elevated levels of MPO were observed in MELF and middle-ear mucosa of patients with AOM. 15,16 Although high expression of MPO in AOM contributes to microbicidal activity, it does worsen middle-ear tissue injury. Our e results showed that the levels of ROS, LDH, TNF-α and IL-1β were reduced following the inhibition of MPO.…”

Section: Discussionmentioning

confidence: 99%

The critical role of myeloperoxidase in Streptococcus pneumoniae clearance and tissue damage during mouse acute otitis media

et al. 2017

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“…MPO is capable of producing hypohalous acids with antimicrobial activities [5,15,16], and increased MPO expression is associated with the cholesteato-…”

Section: Mechanisms Of Cholesteatoma-induced Bone Destructionmentioning

confidence: 99%

“…ma-related destruction of bone [5,16]. High concentrations of the bacterial lipopolysaccharides (LPS) associated with prolonged inflammation may evoke MPO activity in cholesteatomas [16].…”

Section: Case Reportmentioning

confidence: 99%

Dangers of a False Sense of Security in a Huge Mastoid Cholesteatoma With Skull Base Erosion and Cerebrospinal Fluid Leakage

Kuo¹

2020

AOHNS

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Cholesteatomas of mastoid origin often grow silently, remaining unidentified and untreated for years. Cholesteatomas may not even be detected until they are quite massive, and diagnosis may only occur as a result of incidental imaging. Here, we report a case involving a 59-year-old man with delayed presentation of a huge mastoid cholesteatoma complicated by skull base erosion and cerebrospinal fluid leakage. Regular otologic, audiologic, and imaging examinations are the best strategies to avoid undesirable consequences related to chronic otitis media with cholesteatoma. Early recognition of this rare comorbid condition is essential because appropriate and timely treatment can prevent it from becoming fatal.

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“…Myeloperoxidase reacts with hydrogen peroxide in neutrophil phagolysosomes to form a complex for the oxidation of chloride to hypochlorous acid and other toxic products. In cholesteatoma, excessive secretion of reactive oxygen species and myeloperoxidase has been shown to be correlated with bone erosion 55 …”

Section: Lipid Overviewmentioning

confidence: 99%