Myocardial Depression in Sepsis: Beneficial Adaptation or Sequelae that Requires Treatment?

Rumery, Kyle K.; Yunus, Fahd; Frishman, William H.

doi:10.1097/crd.0000000000000301

Cited by 9 publications

(6 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early theories of sepsis-related heart dysfunction were based on the “global myocardial ischemia” hypothesis. But this hypothesis has been dismissed by laboratory and clinical studies showing a decrease in cardiac oxygen utilization and high coronary flow in sepsis [ 21 ]. Also, it seems that sepsis-induced cardiac dysfunction is an acute and reversible response similar to a self-protection response in which functional alterations rather than structural abnormalities are involved in its pathophysiology [ 1 ].…”

Section: Sepsis-related Myocardial Dysfunctionmentioning

confidence: 99%

An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach

Mokhtari

Yavari

Badalzadeh

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Sepsis is defined as a life-threatening organ failure due to dysregulated host response to infection. Despite current advances in our knowledge about sepsis, it is still considered as a major global health challenge. Myocardial dysfunction is a well-defined manifestation of sepsis which is related to worse outcomes in septic patients. Given that the heart is a mitochondria-rich organ and the normal function of mitochondria is essential for successful modulation of septic response, the contribution of mitochondrial damage in sepsis-related myocardial dysfunction has attracted the attention of many scientists. It is widely accepted that mitochondrial damage is involved in sepsis-related myocardial dysfunction; however, effective and potential treatment modalities in clinical setting are still lacking. Mitochondrial-based therapies are potential approaches in sepsis treatment. Although various therapeutic strategies have been used for mitochondrial function improvement, their effects are limited when mitochondria undergo irreversible alterations under septic challenge. Therefore, application of more effective approaches such as mitochondrial transplantation has been suggested. This review highlights the crucial role of mitochondrial damage in sepsis-related myocardial dysfunction, then provides an overview on mitochondrial-based therapies and current approaches to mitochondrial transplantation as a novel strategy, and proposes future directions for more researches in this field.

show abstract

Section: Sepsis-related Myocardial Dysfunctionmentioning

confidence: 99%

An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach

Mokhtari

Yavari

Badalzadeh

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

show abstract

“…Sepsis can further develop into multiple organ failure [ 1 ], and the heart is one of the most vulnerable organs [ 2 ]. sepsis is characterized by profound and sustained inflammatory response, but previous clinical trials of anti-inflammatory therapies to counteract excessive inflammation in patients with sepsis are unsatisfying.…”

Section: Introductionmentioning

confidence: 99%

Protection of melatonin treatment and combination with traditional antibiotics against septic myocardial injury

Jin

Lei

et al. 2023

Cell Mol Biol Lett

View full text Add to dashboard Cite

Background Heart failure is a common complication of sepsis with a high mortality rate. It has been reported that melatonin can attenuate septic injury due to various properties. On the basis of previous reports, this study will further explore the effects and mechanisms of melatonin pretreatment, posttreatment, and combination with antibiotics in the treatment of sepsis and septic myocardial injury. Methods and results Our results showed that melatonin pretreatment showed an obvious protective effect on sepsis and septic myocardial injury, which was related to the attenuation of inflammation and oxidative stress, the improvement of mitochondrial function, the regulation of endoplasmic reticulum stress (ERS), and the activation of the AMPK signaling pathway. In particular, AMPK serves as a key effector for melatonin-initiated myocardial benefits. In addition, melatonin posttreatment also had a certain degree of protection, while its effect was not as remarkable as that of pretreatment. The combination of melatonin and classical antibiotics had a slight but limited effect. RNA-seq detection clarified the cardioprotective mechanism of melatonin. Conclusion Altogether, this study provides a theoretical basis for the application strategy and combination of melatonin in septic myocardial injury.

show abstract

“…In severe sepsis and septic shock, myocardial depression is the manifestation of septic cardiomyopathy and may attribute to the overwhelming production of inflammatory cytokines, mitochondrial dysfunction, and decreased myofibrillar sensitivity to calcium. [3,4] International sepsis guidelines have been adopted worldwide, and it is widely accepted that the standard treatment for sepsis should concentrate on infection control and optimization of hemodynamic parameters by fluid resuscitation and vasopressor therapy including noradrenaline and vasopressin. [5] These standard treatment also apply to septic cardiomyopathy.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of dobutamine and levosimendan for treatment of sepsis-induced cardiac dysfunction

Guo

Zhang²,

Zhu³

et al. 2022

Medicine

View full text Add to dashboard Cite

Background: Levosimendan and dobutamine are extensively used to treat sepsis-induced cardiomyopathy. Previous studies on whether levosimendan is superior to dobutamine are still controversial. We performed a protocol for systematic review and metaanalysis to compare the efficacy and safety of levosimendan versus dobutamine for the treatment of sepsis-induced cardiomyopathy.Methods: This protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol statement. We will search the following databases: PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, Weipu Journal Database, and Chinese Biomedical Literature Database. The search time will be set from database establishment to February 2022. After literature screening, 2 reviewers will extract data from the respects of general information, methodology, and results. Risk of bias is assessed using the Cochrane Risk of Bias Tool for randomized controlled trials. We will apply RevMan 5.4 software for statistical analysis.

show abstract

Myocardial Depression in Sepsis: Beneficial Adaptation or Sequelae that Requires Treatment?

Cited by 9 publications

References 54 publications

An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach

An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach

Protection of melatonin treatment and combination with traditional antibiotics against septic myocardial injury

Comparison of dobutamine and levosimendan for treatment of sepsis-induced cardiac dysfunction

Contact Info

Product

Resources

About