Myocardial oxygen extraction rate under general anesthesia.

Yusa, T; Obara, Shoichi

doi:10.1620/tjem.133.321

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…The working heart is a highly metabolic organ that under normal resting conditions extracts nearly 70% of the oxygen supplied by the coronary circulation 34,35 representing close to 10% of the total body oxygen consumption. However, the heart has minimal capability for extracting additional oxygen such that increases in metabolic demands can only be met by autoregulatory increases in coronary blood flow through vasodilation of the coronary circuit.…”

Section: Myocardial Abnormalities During Cardiac Resuscitationmentioning

confidence: 99%

Protecting Mitochondrial Bioenergetic Function During Resuscitation from Cardiac Arrest

Gazmuri

Radhakrishnan

2012

Critical Care Clinics

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Synopsis Successful resuscitation from cardiac arrest requires reestablishment of aerobic metabolism by reperfusion with oxygenated blood of tissues that have been deprived of oxygen for variables periods of time. However, reperfusion concomitantly activates pathogenic mechanisms known as “reperfusion injury.” At the core of reperfusion injury are mitochondria, playing a critical role as effectors and targets of such injury. Mitochondrial injury compromises oxidative phosphorylation and also prompts release of cytochrome c to the cytosol and bloodstream where it correlates with severity of injury. Main drivers of such injury include Ca2+ overload and oxidative stress. Preclinical work shows that limiting myocardial cytosolic Na+ overload at the time of reperfusion attenuates mitochondrial Ca2+ overload and maintains oxidative phosphorylation yielding functional myocardial benefits that include preservation of left ventricular distensibility. Preservation of left ventricular distensibility enables hemodynamically more effective chest compression. Similar myocardial effect have been reported using erythropoietin hypothesized to protect mitochondrial bioenergetic function presumably through activation of pathways similar to those activated during preconditioning. Incorporation of novel and clinical relevant strategies to protect mitochondrial bioenergetic function are expected to attenuate injury at the time of reperfusion and enhance organ viability ultimately improving resuscitation and survival from cardiac arrest.

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Section: Myocardial Abnormalities During Cardiac Resuscitationmentioning

confidence: 99%

Protecting Mitochondrial Bioenergetic Function During Resuscitation from Cardiac Arrest

Gazmuri

Radhakrishnan

2012

Critical Care Clinics

View full text Add to dashboard Cite

show abstract

“…The working heart is a highly metabolic organ that under normal resting conditions extracts nearly 70% of the oxygen supplied by the coronary circulation (1,2) representing close to 10% of the total body oxygen consumption. However, the heart has minimal capability for extracting additional oxygen, such that increases in metabolic demands can only be met by autoregulatory increases in coronary blood flow through vasodilatation of the coronary circuit.…”

Section: Myocardial Ischemic Injury During Cardiac Resuscitationmentioning

confidence: 99%

NHE-1 Inhibitors and Erythropoietin for Maintaining Myocardial Function during Cardiopulmonary Resuscitation

Gazmuri

Ayoub

Radhakrishnan

2010

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“…The working heart is a highly metabolic organ that under normal resting conditions extracts nearly 70% of the oxygen supplied by the coronary circulation (1,2) representing close to 10% of the total body oxygen consumption. However, the heart has minimal capability for extracting additional oxygen such that increases in metabolic demands can only be met by autoregulatory increases in coronary blood flow through vasodilation of the coronary circuit.…”

Section: Introductionmentioning

confidence: 99%

Protecting mitochondrial bioenergetic function

2010

View full text Add to dashboard Cite

show abstract

Myocardial oxygen extraction rate under general anesthesia.

Cited by 5 publications

References 5 publications

Protecting Mitochondrial Bioenergetic Function During Resuscitation from Cardiac Arrest

Protecting Mitochondrial Bioenergetic Function During Resuscitation from Cardiac Arrest

NHE-1 Inhibitors and Erythropoietin for Maintaining Myocardial Function during Cardiopulmonary Resuscitation

Protecting mitochondrial bioenergetic function

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