“…This protocol for patients with high PRA has been shown to lead to a significant decrease in PRA after desensitization. 5 Rejection surveillance was conducted by echocardiography, with the timing of right ventricular endomyocardial biopsies guided by echocardiographic findings, as previously described, [6][7][8][9][10] and protocol-timed biopsies. Echocardiographic surveillance of systolic and diastolic function predicts biopsy abnormalities and decreases the number of cardiac catheterizations.…”
Section: Protocol For Immunosuppression and Surveillancementioning
Excellent results are expected for children undergoing HTx with comparable results among diagnostic groups. Pretransplant mechanical circulatory support and posttransplant mechanical circulatory support are risk factors for decreased survival. Survival after transplantation for HLHS or HLHS-related malformation is better with primary HTx in comparison to HTx after prior cardiac surgery.
“…This protocol for patients with high PRA has been shown to lead to a significant decrease in PRA after desensitization. 5 Rejection surveillance was conducted by echocardiography, with the timing of right ventricular endomyocardial biopsies guided by echocardiographic findings, as previously described, [6][7][8][9][10] and protocol-timed biopsies. Echocardiographic surveillance of systolic and diastolic function predicts biopsy abnormalities and decreases the number of cardiac catheterizations.…”
Section: Protocol For Immunosuppression and Surveillancementioning
Excellent results are expected for children undergoing HTx with comparable results among diagnostic groups. Pretransplant mechanical circulatory support and posttransplant mechanical circulatory support are risk factors for decreased survival. Survival after transplantation for HLHS or HLHS-related malformation is better with primary HTx in comparison to HTx after prior cardiac surgery.
“…Rejection surveillance is conducted by echocardiography and echocardiographically-directed endomyocardial biopsy, as previously described by our group and others. [8][9][10][11][12] Echocardiographic surveillance of systolic and diastolic function predicts biopsy abnormalities and decreases the number of cardiac catheterizations. Biopsy is performed when the echocardiogram is suspicious for rejection.…”
Section: Immunosuppression and Surveillancementioning
Cardiac transplantation can offer children with failing staged palliation their only chance of survival. Transplantation, however, carries a high risk in this subgroup, especially in the setting of elevated panel reactive antibody.
“…11 To date, the predictive value of TDI-derived indices of diastolic performance in pediatric heart recipients has been reported only in preliminary form. 12 DiastvelLVPWmax, determined from digitized M-mode echocardiograms, has been reported to become abnormal in both pediatric and adult heart recipients with rejection. 13,14 M-mode-derived diastvelLVPWmax has been found to be a highly predictive index of endomyocardial biopsy scores Ն3.…”
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