Myocarditis

Mason, Jay W.; Trehan, Sanjeev; Renlund, Dale G.

doi:10.1007/978-1-84628-715-2_62

Cited by 5 publications

(5 citation statements)

References 447 publications

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“…Whether and why there are geographic differences concerning the distribution of different virus species in myocarditis are currently debated (7). Local and temporal epidemiological differences of virus infections have to be considered, as well as different diagnostic procedures (8). The discussion, whether PVB19 is an innocent bystander or a pathological agent and whether quantification of virus load is a helpful approach, is ongoing (9).…”

mentioning

confidence: 98%

Update on Myocarditis

Kindermann¹,

Barth²,

Mahfoud³

et al. 2012

Journal of the American College of Cardiology

837

741

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Myocarditis is an inflammatory disease of the heart frequently resulting from viral infections and/or post-viral immune-mediated responses. It is one of the important causes of dilated cardiomyopathy worldwide. The diagnosis is presumed on clinical presentation and noninvasive diagnostic methods such as cardiovascular magnetic resonance imaging. Endomyocardial biopsy remains the gold standard for in vivo diagnosis of myocarditis. The therapeutic and prognostic benefits of endomyocardial biopsy results have recently been demonstrated in several clinical trials. Although remarkable advances in diagnosis, understanding of pathophysiological mechanisms, and treatment of acute myocarditis were gained during the last years, no standard treatment strategies could be defined as yet, apart from standard heart failure therapy and physical rest. In severe cases, mechanical support or heart transplantation may become necessary. There is some evidence that immunosuppressive and immunomodulating therapy are effective for chronic, virus-negative inflammatory cardiomyopathy. Further investigations by controlled, randomized studies are needed to definitively determine their role in the treatment of myocarditis.

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mentioning

confidence: 98%

Update on Myocarditis

Kindermann¹,

Barth²,

Mahfoud³

et al. 2012

Journal of the American College of Cardiology

837

741

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“…Sudden death under the age of 35 is rare and usually due to cardiac causes [1][2][3]5]. Studies show that about two-thirds of the autopsies of deceased young people are associate with a structural heart disease.…”

Section: Discussionmentioning

confidence: 99%

“…M yocarditis is an inflammatory disease of the heart muscle (myocardium) [1][2][3][4][5][6]. Depending on the rate of occurrence it can be acute or chronic, and based on the etiology -myocarditis with infectious origin caused by viruses, bacteria, spirochetes, rickettsia, fungi, parasites, protozoa [7,8] and one with non-infectious origin after taking drugs, chemical elements and compounds, after influence of physical factors, insect bites, reptile bites, etc [1][2][3]9].…”

mentioning

confidence: 99%

“…From pathological perspective changes can be focal and diffuse. Most often necrosis and degeneration of myocytes, and cellular infiltration into the interstitium can be observed and in some specific myocarditis granulomas are formed [5,7,[16][17][18]. The clinical picture of myocarditis has very different presentation that varies from asymptomatic cases with mild focal myocarditis to rapidly progressing and fatal heart failure with diffuse, severe myocarditis, making diagnosis difficult.…”

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confidence: 99%

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Sudden death due to asymptomatic myocarditis – a forensic case report

Kiryakova¹,

Nikolov²,

Alexandrov³

2016

RJLM

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Myocarditis is a disease associated with inflammation and damage of the myocardium. It has a very diverse clinical manifestation from asymptomatic cases to fatal heart failure and sudden death. Early diagnosis and treatment is very important. In young people it is one of the common causes of sudden unexpected death. We present a case of a 31 year old man, who was found dead in his apartment. He never had complained of health problems, even prior to his death. Full forensic examination of the body was performed with subsequent chemical and histological analysis. The results showed that he suffered from asymptomatic myocarditis.

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“…Myocarditis of any etiology usually presents with cardiac failure and ventricular arrhythmia. As a result, myocarditis is one of the most common causes of sudden death in patients without pre-existing structural heart disease [1].…”

Section: Introductionmentioning

confidence: 99%

Fatal septic shock caused by candida myocarditis associated with malignant lymphoma and Epstein-Barr virus mediated disorder

Saïd¹,

Liebrand²,

Bansraj³

et al. 2011

OJIM

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A 60-year-old man with known epilepsy was admitted to our hospital due to hypotension, fever and arrhythmia. He was treated medically and myocardial infarction was ruled out. Treatment of septic shock was established according to the guidelines of the early goal-guided therapy including vasopressors, inotropic agents, mechanical ventilation, and hemofiltration in combination with empirical treatment with antimicrobial drugs and hydrocortisone. The patient’s condition deteriorated rapidly into multiorgan failure resulting in a fatal outcome. Antemortem blood cultures were sterile. Autopsy findings were compatible with Epstein-Barr virus mediated lymphoproliferative disorder, malignant lymphoma, disseminated candidiasis and candida myocarditis. Post-mortem blood and tissue cultures were positive for growth of candida glabrata and candida albicans, respectively. The post-mortem examination documented Epstein-Barr virus mediated lymphoproliferative disorder and malignant small cell lymphoma associated with candida myocarditis. Prior to death, the patient did not receive antiviral or antifungal treatment. Fatal candida myocarditis associated with septic shock secondary to disseminated candidiasis in a 60-years old male patient with prior unknown immune compromised state caused by Epstein-Barr virus mediated lymphoproliferative disorder and malignant lymphoma is described

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Myocarditis

Cited by 5 publications

References 447 publications

Update on Myocarditis

Update on Myocarditis

Sudden death due to asymptomatic myocarditis – a forensic case report

Fatal septic shock caused by candida myocarditis associated with malignant lymphoma and Epstein-Barr virus mediated disorder

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