Myogenic autoregulation in bone marrow arterioles and in vivo intramedullary pressure in femora of conscious, female Long Evans rats

Abstract

Blood supply to bone and marrow is critical for meeting the oxygen and nutrient requirements of the tissue, as well as for eliminating metabolic byproducts. In addition, blood supply to the skeleton ensures its fluidic nature, 1 allowing for IMP and IFF. Intramedullary pressure and IFF are critical for the maintenance of bone structure since alterations in these physiological parameters with mechanical loading elicit bone gain or loss. The generated shear stress on bone cell (e.g., osteoclasts, osteocytes, and osteoblasts) surfaces with fluctuations in IMP and IFF stimulates the production and subsequent release of a variety of factors (e.g., NO, PGE 2 , and ATP) 2-7 that