Myopericarditis caused by severe acute respiratory syndrome coronavirus 2

Özturan, İbrahim Ulaş; Köse, Beril; Özkan, Bülent; Köse, Ataman

doi:10.15441/ceem.20.109

Cited by 3 publications

(19 citation statements)

References 14 publications

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“…The common theme of the studies was either the identification of only pericarditis [10,11,14,16,19,23,26,28,30,35,37,38,40], myopericarditis [13,18,20,21,24,25,29,33,34], or the association of cardiac tamponade or pericardial effusion and either pericarditis or myopericarditis [9,12,15,17,22,27,31,32,36,39,41] in COVID-19 patients.…”

Section: Results Of Individual Studiesmentioning

confidence: 99%

“…In total, 29 articles selected for this study were case reports [9][10][11][12][13][14][15][17][18][19][20][22][23][24][25][26][27][28][29][30][31][32][33][34][35][38][39][40][41] while four were case series [16,21,36,37]. All articles were published in 2020 [9][10][11]13,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]…”

Section: Study Characteristicsmentioning

confidence: 99%

“…All articles were published in 2020 [9][10][11]13,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][31][32][33][34][35][36][37][39][40][41], except four, which were published in 2021 [12,14,30,38]. The majority of the studies were conducted in the United States [9,10,15,16,[20][21][22]25,[30][31][32][38][39][40][41], followed by countries from the European Union or United kingdom [11,12,18,…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The predominant symptom at admission was chest pain [9,11,[13][14][15][16][17]19,21,23,24,[27][28][29][30]32,33,37,38], followed by fever [12,15,17,18,[20][21][22]25,[28][29][30][31][33][34][35]40,41], shortness of breath [10,13,15,17,20,22,[24][25][26]28,29,32,34,35,38,39,41]…”

Section: Presenting Complaintsmentioning

confidence: 99%

“…Nine out of 10 studies recorded elevated nterminal brain natriuretic peptide (BNP), with a mean value of 4,770.1 ± 5,158.2 pg/mL [11,18,21,24,25,32,34,38,39,41]. Only three studies reported elevated creatine kinase-MB results, with a mean of 39.9 ± 13.3 ng/mL [22,25,29].…”

Section: Laboratory Testsmentioning

confidence: 99%

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A Systematic Review of COVID-19 and Pericarditis

Kariyanna¹,

Ahmed²,

Sutarjono³

et al. 2022

Cureus

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Coronavirus disease 2019 , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China in December 2019. Since then, the disease has spread globally, leading to the ongoing pandemic. It can cause severe respiratory illness; however, many cases of pericarditis have also been reported. This systematic review aims to recognize the clinical features of pericarditis and myopericarditis in COVID-19 patients.Google Scholar, Medline/PubMed, CINAHL, Cochrane Central, and Web of Science databases were searched for studies reporting "Coronavirus" or "COVID" and "Peri-myocarditis," "heart," or "retrospective." Case reports and retrospective studies published from May 2020 to February 2021 were reviewed.In total, 33 studies on pericarditis, myopericarditis, and pericardial infusion were included in this review. COVID-19 pericarditis affected adult patients at any age. The incidence is more common in males, with a male-to-female ratio of 2:1. Chest pain (60%), fever (51%), and shortness of breath (51%) were the most reported symptoms, followed by cough (39%), fatigue (15%), myalgia (12%), and diarrhea (12%). Laboratory tests revealed leukocytosis with neutrophil predominance, elevated D-dimer, erythrocyte rate, and Creactive protein. Cardiac markers including troponin-1, troponin-T, and brain natriuretic peptide were elevated in most cases. Radiographic imaging of the chest were mostly normal, and only 31% of chest X-rays showed cardiomegaly and or bilateral infiltration. Electrocardiography (ECG) demonstrated normal sinus rhythm with around 59% ST elevation and rarely PR depression or T wave inversion, while the predominant echocardiographic feature was pericardial effusion. Management with colchicine was favored in most cases, followed by non-steroidal anti-inflammatory drugs (NSAIDs), and interventional therapy was only needed when patient developed cardiac tamponade. The majority of the reviewed studies reported either recovery or no continued clinical deterioration.The prevalence of COVID-19-related cardiac diseases is high, and pericarditis is a known extrapulmonary manifestation. However, pericardial effusion and cardiac tamponade are less prevalent and may require urgent intervention to prevent mortality. Pericarditis should be considered in patients with chest pain, ST elevation on ECG, a normal coronary angiogram, and COVID-19. We emphasize the importance of clinical examination, ECG, and echocardiogram for decision-making, and NSAIDs, colchicine, and corticosteroids are considered to be safe in the treatment of pericarditis/myopericarditis associated with COVID-19.

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Section: Results Of Individual Studiesmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Presenting Complaintsmentioning

confidence: 99%

Section: Laboratory Testsmentioning

confidence: 99%

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A Systematic Review of COVID-19 and Pericarditis

Kariyanna¹,

Ahmed²,

Sutarjono³

et al. 2022

Cureus

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Acute Psychosis in COVID-19: Is It Due to Favipiravir Treatment or Acute Viral Illness?

Duyan

Özturan

2021

SN Compr. Clin. Med.

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In this report, we present a case of acute psychosis that occurred after the loading dose of favipiravir, one of the most prescribed antiviral drugs in many countries, in a patient with COVID-19. A 31-year-old female was readmitted to the emergency department after 3 days of sleep disturbance, intermittent paranoid delusions, auditory hallucinations, and agitation that started after the favipiravir treatment was initiated. A physical examination revealed disorganized speech, distorted orientation, and agitation. All laboratory tests, including drug screening and cerebrospinal fluid analysis, were normal. After excluding all the other causes of acute psychosis, favipiravir treatment was discontinued, antipsychotic treatment was started, and the patient was admitted to the psychiatric ward. The symptoms resolved on the second day of hospitalization. Although acute viral illness does seldomly cause psychosis in patients with increased inflammatory response, in the presented case, none of the inflammatory markers were positive, and acute psychosis was attributed to the loading dose of favipiravir. In conclusion, clinicians should be aware of this rare adverse effect and prescribe cautiously to patients at a high risk of psychosis.

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Acute Pericarditis as the Primary Presentation of COVID-19 Infection followed by Guillain-Barre Syndrome in a Healthy Young Man: A Case Report

Noghabaei¹,

Arab²,

Payami³

et al. 2022

TORMJ

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Background: Symptomatic COVID-19 infection most often presents as acute respiratory distress syndrome. Acute pericarditis and Guillain–Barré syndrome are rare extrapulmonary manifestations of this infection. Case presentation: A 27-year-old man presented with chest pain, with negative troponin and typical electrocardiographic findings, resulting in a diagnosis of acute pericarditis. He had no respiratory symptoms, nor the chest computerized tomography (CT) scan findings of COVID-19, and his Polymerase chain reaction (PCR) was negative. One week later, he developed clinical symptoms of Guillain-Barre syndrome, along with respiratory manifestations of COVID-19. His repeat chest CT scan and PCR test confirmed COVID-19 infection. After 17 days of hospital stay, he improved clinically and was discharged. Conclusion: This is the first case of acute pericarditis as the primary presentation of COVID-19 in the absence of respiratory symptoms and clear chest CT scan, followed by the development of Guillain–Barré syndrome and respiratory tract manifestations of COVID-19. Clinicians should be aware of extrapulmonary presentation of COVID-19 infection.

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Myopericarditis caused by severe acute respiratory syndrome coronavirus 2

Cited by 3 publications

References 14 publications

A Systematic Review of COVID-19 and Pericarditis

A Systematic Review of COVID-19 and Pericarditis

Acute Psychosis in COVID-19: Is It Due to Favipiravir Treatment or Acute Viral Illness?

Acute Pericarditis as the Primary Presentation of COVID-19 Infection followed by Guillain-Barre Syndrome in a Healthy Young Man: A Case Report

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