Myositis-Specific Autoantibodies

Miller, Frederick W.

doi:10.1001/jama.1993.03510150080034

Cited by 81 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6(c)] imposes a restriction on Az, the range of redshifts that is surveyed, and so results in a smaller surveyed volume. Most of this work consists of optical searches for Lya at redshifts of order 2-6 using CCDs and narrow-band interference filters (e.g., Cowie 1988;Hartwick 1987, 1990;Rhee, Webb, and Katgert 1989;Smith et al 1989;Wolfe et al 1992;Djorgovski and Thompson 1992;Djorgovski, Thompson, and Smith 1993;De Propris et al 1993;Miller and Warren 1993;Macchetto et al 1993), or with a Fabry-Perot system (Djorgovski, Thompson, Djorgovski, and Trauger 1992). The limiting flux for these surveys is much improved over slitless spectroscopy-typical flux limits are between 10 -16 and 1CT 17 erg cm -2 s -1 , and typical CCD fields now approach 0.01-0.1 deg 2 (or larger for CCD mosaics) on 4-m class telescopes.…”

Section: Searches For Uv-optical Emission Linesmentioning

confidence: 99%

The search for primeval galaxies

Pritchet¹

1994

PASP

View full text Add to dashboard Cite

Isolated examples of young star-forming galaxies have been discovered, but the predicted widespread population of primeval galaxies (estimated to have surface densities in the range 10 4 " 5 deg -2 ) has so far escaped detection. The search for this extensive (and, so far, elusive) population concerns the formation of spheroidal systems (bulges and halos), since there is considerable evidence that disk formation was more quiescent. The review begins with a summary of the expected model independent properties of primeval galaxies. Particular attention is paid to the redshift of galaxy formation; empirical evidence is presented that supports galaxy formation at z<5; however, there exist persuasive arguments that at least some galaxy formation must have taken place at higher redshifts. A major part of this review concerns primeval-galaxy search strategies. Most (although not all) constraints on the properties of primeval galaxies come from searches for Lyman-alpha-emitting objects. Flux limits for these searches have now reached levels at which surveys should, according to simple models, have detected a total of 10 1 " 3 objects, yet no really good candidates have been found. This discrepancy between models and observations can possibly be explained by a combination of (i) dust absorption, and (ii) finite angular extent, which degrades flux limits. Technological advances in submillimeter instrumentation should result in the detection of the far-IR flux of primeval galaxies in the next few years.

show abstract

Section: Searches For Uv-optical Emission Linesmentioning

confidence: 99%

The search for primeval galaxies

Pritchet¹

1994

PASP

View full text Add to dashboard Cite

show abstract

“…In our patient, myositis-specific autoantibodies and PM/Scl were not present in serum samples obtained either before diagnosis, at the time of diagnosis, or 1 year after the episode of FM. However, the identification, in this case, of the HLA allele DQAl*0501, seen in 68% of white patients with myositis (relative risk 5.3) (32,33), suggests that some cases of FM and idiopathic inflammatory myopathies may, in fact, share common genetic risk factors. This finding warrants further study.…”

Section: Case Reportmentioning

confidence: 72%

Focal myositis presenting as pseudothrombophlebitis of the neck in a patient with mixed connective tissue disease

Rivest¹,

Miller²,

Love³

et al. 1996

Arthritis & Rheumatism

Self Cite

View full text Add to dashboard Cite

This report describes a case of focal myositis in a patient with mixed connective tissue disease. The patient presented with diffuse neck swelling and pseudothrombophlebitis of the left internal jugular vein. Other clinical features included a high fever, elevated erythrocyte sedimentation rate, and prompt improvement after administration of high-dose intravenous corticosteroid therapy. Criteria for polymyositis were absent, serum levels of creatine kinase remained normal, and there was no sign of recurrence during 3 years of followup. Results of immunoprecipitation for anti-Jo-1 and other myositis-specific autoantibodies remained negative in serial serum samples obtained before, during, and after the episode.

show abstract

“…Idiopathic inflammatory myopathies consist of autoimmune disorders that affect muscle, skin, joints, lung, and other organs. Subtypes include necrotizing myopathy, eosinophilic myositis, and granulomatous myositis [6]. The mechanisms of tissue injury in these myopathies are not well understood [7].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Necrotizing Myopathy and Fibrinous and Organizing Pneumonia with Anti-EJ Antisynthetase Syndrome and SSA Antibodies

et al. 2017

View full text Add to dashboard Cite

Objective:Rare co-existance of disease or pathology Background:Idiopathic inflammatory myopathies are autoimmune disorders that can involve the skin, joints, muscles, and lungs. The most common of these disorders are dermatomyositis, polymyositis, overlap syndrome, and inclusion body myositis. Necrotizing autoimmune myopathy is an idiopathic inflammatory myopathy that is rarely associated with Sjögren's syndrome. The most common lung findings associated with anti-EJ antisynthetase syndrome are nonspecific interstitial pneumonia and usual interstitial pneumonia; this condition is rarely associated with fibrinous and organizing pneumonia. Case Report:Here, we present a rare case of necrotizing myopathy and fibrinous and organizing pneumonia in a 34-yearold African American man with Sjögren's syndrome and anti-EJ antibodies. The patient's presenting symptoms were cough and proximal muscle weakness of the extremities. He had elevated serum creatine kinase level, aldolase level, and erythrocyte sedimentation rate. Myositis panel was positive for anti-EJ antibodies. Chest radiography was consistent with bilateral interstitial infiltrates. CT chest showed patchy bilateral infiltrates. Quadriceps muscle biopsy revealed widespread necrotic fibers and lung biopsy showed fibrinous and organizing pneumonia. The patient responded well to immunoglobulin therapy, mycophenolate, and prednisone, which resulted in complete resolution of bilateral infiltrates and improved muscle pain and weakness. Conclusions:Myopathies are characterized by myalgia and muscle weakness due to muscle fiber dysfunction and are associated with autoimmune diseases. Histopathological features may differ in idiopathic inflammatory myopathies. It is important to recognize the rare association of anti-EJ autoantibodies with necrotizing myopathy and interstitial lung disease, which responds well to methylprednisolone and intravenous immunoglobulin.

show abstract

Myositis-Specific Autoantibodies

Cited by 81 publications

References 21 publications

The search for primeval galaxies

The search for primeval galaxies

Focal myositis presenting as pseudothrombophlebitis of the neck in a patient with mixed connective tissue disease

A Rare Case of Necrotizing Myopathy and Fibrinous and Organizing Pneumonia with Anti-EJ Antisynthetase Syndrome and SSA Antibodies

Contact Info

Product

Resources

About