Myostatin Gene as a Genetic Marker for Growth and Carcass Traits in Beef Cattle

Abstract

<p>Growth and carcass traits are of economic importances in livestock breeding, because they affect the profitability of animal production. The phenotypic expression of these traits is controlled by multiple genes (polygenes), such as myostatin (MSTN) gene. This paper aims to discuss the expression, polymorphism and potential application of MSTN gene as a marker-assisted selection (MAS) for growth and carcass traits in beef cattle based on data from published studies. MSTN gene or known as growth and differentiation factor 8 (GDF8) is a member of the transforming growth factor-β (TGF-β) superfamily, which acts as a negative regulator of skeletal muscle mass deposition. Several published studies showed that mutations in the MSTN gene can inhibit the activation of myostatin, which leads to an increased muscle mass (hypertrophy). Several <em>MSTN</em> gene polymorphisms were reported to be associated with growth and carcass traits in local cattle in several countries, including Indonesia, namely Bali cattle. Based on several assumptions: 1) there is MTSN gene polymorphisms in a population, 2) there is a significant association between MSTN gene polymorphisms and growth and carcass traits, as reported in several beef cattle populations and 3) those cattle with superior genotype have better growth performances, we expect that there will be improvement in growth performances in the future if those cattle are selected. Understanding MSTN gene polymorphisms would be useful to make strategies for the genetic improvement for growth and carcass traits of local cattle.</p>

Genetic polymorphism of myostatin gene in Sumba Ongole (Bos indicus) cattle and its association with growth traits

“…Considering the importance of this gene, investigation of the biological roles of the MSTN gene in Ongole cattle is required because mutations in some of the other beef cattle, including European cattle [ 23 , 27 , 28 ], Australian breeds [ 30 ], and Indonesian beef cattle [ 31 , 32 , 35 ] are associated with growth traits. The literature search revealed that there is no prior research examining the allelic and genotypic frequencies of the MSTN gene in SO cattle, making direct comparisons with other studies in Ongole cow breeds worldwide difficult.…”

“…The role of the MSTN gene in economic production has been identified in various breeds of beef cattle, such as Belgian blue [ 26 ], Nellore cattle [ 25 , 27 ], Piemontese young bulls [ 23 , 28 ], Russian cattle [ 2 ], Marchigiana bulls [ 3 ], and, Chinese yellow cattle [ 29 ]. The trait can be found in Australian beef cattle [ 30 ] and in some breeds of Indonesian beef cattle, such as the Peranakan Ongole (PO), the Belgian Blue × PO hybrid, and the PO × Pegolo Bali cattle [ 31 , 32 ]. However, the result might probably be different from other Ongole beef cattle extensively grazed under a harsh environment in a tropical semi-arid region, such as Sumba Island [ 33 ].…”

Analisis Keanekaragaman Gen Myostatin (Mstn) Secara in-Silico Pada Cattle Di Indonesia

“…Karakterisasi gen MSTN akan sangat bermanfaat bagi beberapa cattle di Indonesia (Prihandini et al, 2021). Namun, karakterisasi ini belum sepenuhnya dilakukan.…”

Biodiversity of Indonesian indigenous buffalo: First review of the status, challenges, and development opportunities

“…Improving meat quality: Meat from buffalo is highly valued in Indonesia. Genetic selection can help identify animals with desirable meat quality traits, such as marbling, tenderness, and flavor, improving the value and marketability of buffalo meat [91,92]. Data management systems and software applications can support the genetic improvement of buffaloes at BPTU-HPT.…”