Myostatin: more than just a regulator of muscle mass

Argilés, Josep Μ.; Orpí, Marcel; Busquets, Sı́lvia; López‐Soriano, Francisco J.

doi:10.1016/j.drudis.2012.02.001

Cited by 110 publications

(78 citation statements)

References 89 publications

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“…Миостатин рассматривается как негативный регулятор роста скелетной мускулатуры и причисля-ется к миокинам. В то же время при его дефиците могут ингибироваться адипогенез и прибавка жира в теле на фоне высокожировой диеты, вопреки тому, что ка-хексия, присущая и части онкологических больных (но не при РЭ), хотя и сопровождается уменьшением О р и г и н а л ь н ы е р а б о т ы объема жировой ткани, в большей степени основана на утрате мышечной массы [24]. Сопоставляя эти сведения и достаточно хорошо из-вестные данные о связях лептина, инсулина и некото-рых цитокинов с ожирением и присущим немалой части его случаев легким хроническим воспалением [25], есть основания задаться вопросом, правомочным ли было подразделение больных РЭ на группу со «стан-дартным» и «метаболически здоровым» фенотипом избыточной массы тела (а не ожирения), несмотря на отмечавшуюся выше неопределенность дефини-ций «метаболического здоровья» и, соответственно, некоторую субъективность в выборе его критериев.…”

Section: результаты и обсуждениеunclassified

Adipokines, myokines and cytokines in endometrial cancer patients: relations to obesity phenotype of excessive body mass and features of the tumor

2017

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Aim. To study serum content of a number of known adipokines, myokines and cytokines and compare obtained data with overweight phenotype and characteristics of tumor in untreated patients with endometrial cancer (EC) Materials and methods. The study included 88 patients with a mean age 60.080.67 years and a mean body mass index (BMI) 32.900.83. Patients were subjected to anthropometry and analysis of laboratory parameters, including serum level of leptin, adiponectin, omentin, prefilin (Pref-1), myostatin, irisin, IL-6 as well as insulinemia and insulin resistance index (HOMA-IR). On the basis of combination of anthropometric and laboratory data patients with overweight (BMI 25.0) were subdivided into the groups with "standard" (S) and conditionally "metabolically healthy" (MH) phenotype. Results. Levels of leptin, insulin and adiponectin in the serum of patients with EC are associated with BMI value and demonstrate significant differences between S and MH groups. Levels of prefilin, myostatin, and IL-6 are not associated with an increase in BMI, but are also different in patients with S and MH phenotype of overweight.For levels oа irisin, omentin, and TNF-alphathere is no peculiar dependence both, the BMI, and of belonging to a group with S or MH phenotype. Omentin level in the serum is associated with less favorable tumor differentiation (MH group), while IL-6 level with a more advanced stage of the tumor (all patients and group S). Conclusion. Adipokines, myokines and cytokines circulating in blood of EC patients vary in their connections with BMI or with "standard" or "metabolically healthy" phenotype of its excess. They vary also in relation to EC features, which in sum may have practical importance.

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Section: результаты и обсуждениеunclassified

Adipokines, myokines and cytokines in endometrial cancer patients: relations to obesity phenotype of excessive body mass and features of the tumor

2017

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“…Both of these signaling pathways converge to upregulate enzymes that drive muscle protein breakdown. These E3 ubiquitin ligase enzymes: atrogin-1 and MuRF-1 positively regulate protein turnover via the ubiquitin proteasome system and are key cachexic factors across diverse models of muscle atrophy ( Figure 1) [10][11][12].…”

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confidence: 99%

Epigenetics of cancer-associated muscle catabolism

et al. 2017

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Cancer patients are commonly affected by cachexia, a wasting process involving muscle and fat. Specifically, loss of the muscle compartment has been associated with poor prognosis and suboptimal response to therapy. Nutritional support has been ineffective in treating this process leading to investigations into the underlying molecular processes governing muscle catabolism. In this commentary, we discuss the molecular mechanisms of cancer-associated muscle metabolism and the epigenetic processes responsible for the muscle wasting phenotype. Ultimately, we highlight how the epigenome may serve as a promising therapeutic target in reversing cancer-associated muscle catabolism.

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“…Essa ação anti-proliferativa está associada ao aumento da expressão da proteína p21 e o subsequente decréscimo da proteína CDK2 (quinase 2 dependente de ciclina) e também do decréscimo dos níveis de proteína retinoblastoma (RB) fosforiladas, o que mantém os mioblastos na fase G1 do ciclo celular (ARGILES et al, 2012;THOMAS et al, 2000).…”

Section: A Miostatina E O Controle Da Massa Muscularunclassified

“…A dimerização desse fragmento maduro de 12 kDa (através de pontes dissulfeto), é que cria a forma ativa da proteína, que tem aproximadamente 28 kDa. (ARGILES et al, 2012;PEIRIS, ASHMAN, et al, 2014).…”

Section: A Miostatina E O Controle Da Massa Muscularunclassified

“…Alguns estudos mostram que a miostatina está envolvida na redução da musculatura esquelética frequentemente observada em doenças crônicas, como insuficiência cardíaca, insuficiência renal, doença pulmonar obstrutiva crônica (DPOC) e câncer (ARGILES et al, 2012;MORISSETTE et al, 2009;MITCH, 2013). Pacientes HIV (vírus da imunodeficiência humana) positivo também demonstraram uma correlação positiva entre os níveis séricos de miostatina e a magnitude da perda muscular (GONZALEZ-CADAVID et al, 1998).…”

Section: A Miostatina Em Diferentes Situações De Atrofiaunclassified

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Efeito da suplementação de leucina na sinalização da via da miostatina durante atrofia muscular esquelética.

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Myostatin: more than just a regulator of muscle mass

Cited by 110 publications

References 89 publications

Adipokines, myokines and cytokines in endometrial cancer patients: relations to obesity phenotype of excessive body mass and features of the tumor

Adipokines, myokines and cytokines in endometrial cancer patients: relations to obesity phenotype of excessive body mass and features of the tumor

Epigenetics of cancer-associated muscle catabolism

Efeito da suplementação de leucina na sinalização da via da miostatina durante atrofia muscular esquelética.

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