Myricetin as a Promising Molecule for the Treatment of Post-Ischemic Brain Neurodegeneration

Abstract

The available drug therapy for post-ischemic neurodegeneration of the brain is symptomatic. This review provides an evaluation of possible dietary therapy for post-ischemic neurodegeneration with myricetin. The purpose of this review was to provide a comprehensive overview of what scientists have done regarding the benefits of myricetin in post-ischemic neurodegeneration. The data in this article contribute to a better understanding of the potential benefits of myricetin in the treatment of post-ischemic brain neurodegeneration, and inform physicians, scientists and patients, as well as their caregivers, about treatment options. Due to the pleiotropic properties of myricetin, including anti-amyloid, anti-phosphorylation of tau protein, anti-inflammatory, anti-oxidant and autophagous, as well as increasing acetylcholine, myricetin is a promising candidate for treatment after ischemia brain neurodegeneration with full-blown dementia. In this way, it may gain interest as a potential substance for the prophylaxis of the development of post-ischemic brain neurodegeneration. It is a safe substance, commercially available, inexpensive and registered as a pro-health product in the US and Europe. Taken together, the evidence available in the review on the therapeutic potential of myricetin provides helpful insight into the potential clinical utility of myricetin in treating neurodegenerative disorders with full-blown dementia. Therefore, myricetin may be a promising complementary agent in the future against the development of post-ischemic brain neurodegeneration. Indeed, there is a scientific rationale for the use of myricetin in the prevention and treatment of brain neurodegeneration caused by ischemia.

Pharmacological Actions of Myricetin in the Nervous System: A Comprehensive Review of Preclinical Studies in Animals and Cell Models

“…The discrepancy of myricetin between its low oral bioavailability and neuroprotective effects could be coordinated by a metabolism hypothesis: the orally administered myricetin could be converted into a metabolite that penetrates the blood-brain-barrier. Mechanistic studies have revealed that inhibition of neuroinflammation, oxidative stress, and cellular apoptosis ( Jang et al, 2020 ; Boriero et al, 2021 ; Deng et al, 2021 ; Hamdi et al, 2021 ; Pluta et al, 2021 ), activation of nuclear factor E2-related factor 2 ( Nrf2 ) ( Wu et al, 2016 ), extracellular signal-regulated kinase 1/2 (ERK1/2) ( Lei et al, 2012 ; Jang et al, 2020 ), protein kinase B (Akt) ( Sun et al, 2018 ), and cyclic adenosine monophosphate-response element binding protein (CREB) ( Lei et al, 2012 ), inhibition of intracellular Ca 2+ increase ( Oyama et al, 1994 ; Chang et al, 2015 ), and inhibition of c-Jun N-terminal kinase (JNK) ( Jang et al, 2020 ) or p38 ( Hagenacker et al, 2010 ; Sun et al, 2018 ; Jang et al, 2020 ) may mediate the neuroprotective actions of myricetin. On the basis of these reports, we conclude that myricetin, dependent on its metabolites which possess neuroprotective activities, could be developed as a potential candidate for the treatment of nervous system disorders.…”

Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease

“…The above data on the possible prominent role of brain ischemia in the induction of Alzheimer-type dementia may open up new innovative (probably preventive) treatments of AD with candidate drugs. One such candidate might be myricetin (a polyphenol) [ 186 ], whose beneficial characteristics seem perfectly tailored in this aim. As a matter of fact, myricetin reduces Aβ and amyloid oligomers/fibrils production, diminishes neuroinflammation, expresses powerful antioxidant activity and elevates brain acetylcholine level.…”

Covid 19: Diet Composition and Health

“…An in vivo study using murine models of sepsis induced by lipopolysaccharides (LPS) and alum-induced peritonitis showed that myricetin inhibits the formation of the NLRP3 inflammasome [ 108 ]. Moreover, due to the pleiotropic properties of myricetin (anti-inflammatory, antioxidant, autophagous, and reduction of the formation of amyloid plaques and tau protein phosphorylation), myricetin is a promising compound for the treatment of neurodegeneration of the brain caused by ischaemia and full-blown dementia [ 109 ].…”