Mysterious Stones

Giasson, Janice; Chen, Yu

doi:10.1373/clinchem.2013.205427

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…Анализ эксклюзии красителя (dye exclusion assay) [67]. Этот метод основан на принципе непроницаемости цитоплазматической мембраны нетрансформированных клеток для витальных красителей и утрате этой способности погибшими клетками в результате дезинтеграции плазмалеммы.…”

Section: методы оценки химиочувствительности опухолевых клеток с испоunclassified

“…Поэтому жизнеспособные клетки после воздействия химиопрепаратов остаются не окрашенными, а погибшие -захватывают краситель и окрашиваются в соответствующий цвет. Таким образом, удается подсчитать численность жизнеспособных и погибших клеток, и по их соотношению судить о степени цитотоксичности испытуемых химиопрепаратов [28,45,56,67,68]. При данном способе тестирования применяются различные красители: прочный зеленый, кристаллический фиолетовый, нейтральный красный, эозин, нигрозин Б, акридиновый оранжевый, трипановый синий [56].…”

Section: методы оценки химиочувствительности опухолевых клеток с испоunclassified

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The methods of in vitro selection of chemotherapeutic druds for individual chemotherapy of maligant tumors in patinets

Chernov

Barantsevich

Kalunov

et al. 2018

Transl. med. (Print)

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The review considers methods for selecting chemo- and biopreparations, their combinations using 2D and 3D cell culture models to predict a personified response of patients with malignant neoplasms (ovarian, stomach, intestine, lung, lacteal, pancreas, head and neck cancer) to chemotherapy. Performance indicators (sensitivity, specificity, prolongation of total and disease-free survival) of chemosensitivity assessment methods in cultures of tumor cells are analyzed on the basis of their comparison with the effectiveness of chemotherapy of patients. The article highlights the advantages and disadvantages of the methods described, the prospects for their further application in clinical practice.

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Section: методы оценки химиочувствительности опухолевых клеток с испоunclassified

The methods of in vitro selection of chemotherapeutic druds for individual chemotherapy of maligant tumors in patinets

Chernov

Barantsevich

Kalunov

et al. 2018

Transl. med. (Print)

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“…6,7 Different stones have their own treatment regimens, therefore, understanding stone composition is necessary to guide proper treatment and understanding different risk factors may help with risk stratification and recurrence prevention. 8 In Canada, such epidemiology studies of urolithiasis have been conducted in Newfoundland and Labrador 9 and Ontario; 4 however, in New Brunswick, such data is lacking.…”

Section: Introductionmentioning

confidence: 99%

The first epidemiology study of urolithiasis in New Brunswick

Chen¹,

Chen

2020

CUAJ

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Introduction: Understanding the compositions of a kidney stone is crucial in leading to proper treatment and in preventing reoccurring urolithiasis. This study aimed to investigate the prevalence of urolithiasis in the province of New Brunswick (NB), Canada. Methods: A total of 3828 kidney stone analysis reports from October 1, 2016 to September 30, 2019, were reviewed from laboratory information systems. Among them, 3311 were identified as new cases. Stone compositions were analyzed by the Fourier Transform Infrared spectrometry. Incident rates were compared using Chi-squared analysis of different age, sex, and regional health authority (RHA) zones. Results: The prevalence of urolithiasis in NB was 147.8 per 100 000 person-years. Males had a significantly higher (X2=254, p<0.001) incident rate of 189 (95% confidence interval [CI] 182–198) than females (107 [95% CI 102–114]) per 100 000 person-years. Zone 1 had significantly higher (245 per 100 000 person-years, p<0.001) prevalence compared to other RHA zones. Age group over 65 years had the highest incidence rate of 253 per 100 00 person-years of all groups. The predominant kidney stone types in NB were whewellite (60.68%) and weddellite (11.58%). Those patients aged 0–18 years had a high percentage of struvite (4.32%) vs. the provincial average (2.19%) (p<0.001). Conclusions: The prevalence of NB’s urolithiasis is slightly higher than that of Ontario. Since both zones 1.1 and 1.2 have significantly high prevalence and are situated in the Moncton area (combined zone 1), it may suggest that geographical factors play a role in the prevalence of urolithiasis in NB.

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Mysterious Stones

Cited by 2 publications

References 3 publications

The methods of in vitro selection of chemotherapeutic druds for individual chemotherapy of maligant tumors in patinets

The methods of in vitro selection of chemotherapeutic druds for individual chemotherapy of maligant tumors in patinets

The first epidemiology study of urolithiasis in New Brunswick

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