Myxoinflammatory Fibroblastic Sarcoma: A Case Report and Review of the Literature

Monson, Erik; VanCourt, Robert; Dawson, John

doi:10.1053/j.jfas.2009.07.028

Cited by 14 publications

(14 citation statements)

References 7 publications

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“…The clinical differential may include long-standing infections or inflammatory conditions such as tenosynovitis; however, these would be readily excluded upon cytologic review [6,12]. Location is unhelpful in excluding other lesions, and although AMFS rarely occurs in proximal/axial sites, the converse is not true as numerous soft tissue neoplasms occur in acral locations.…”

Section: Discussionmentioning

confidence: 99%

“…(3) Myxoid liposarcoma: while AMFS contains lipoblast-like cells, cytoplasmic vacuoles present in AMFS contain mucin rather than fat [6]. AMFS also contains spindle cells with bipolar cytoplasmic extensions [11].…”

Section: Discussionmentioning

confidence: 99%

“…The immunohistochemical features of AMFS are relatively nonspecific and have been reported to include: +vimentin, +CD68, +smooth muscle actin, +CD34, +keratin (variable), Ki-67 < 5%, and +EGFR [6,8]. Strong keratin expression would favor epithelioid sarcoma, while CD15+ and CD30+ large atypical cells would be consistent with Hodgkin lymphoma [13].…”

Section: Discussionmentioning

confidence: 99%

“…Treatment with resection and wide margins has been suggested; if margins cannot be obtained amputation may be considered [6]. Radiation is commonly administered either pre-, intra-, or postoperatively [5].…”

Section: Discussionmentioning

confidence: 99%

“…The World Health Organization describes AMFS as a ‘unique low-grade sarcoma with myxoid stroma, inflammatory infiltrate, and virocyte-like cells that predominately involves the hands and feet’ [3]. There are over 100 reported cases of this characteristically painless tumor that shows ill-defined borders and involves the subcutaneous/dermal tissue of distal extremities [4,5,6,7,8,9]. Despite the name, AMFS has also been reported in the legs and arms [1].…”

Section: Introductionmentioning

confidence: 99%

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Acral Myxoinflammatory Fibroblastic Sarcoma: Cytopathologic Findings on Fine-Needle Aspiration

2013

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Background: Acral myxoinflammatory fibroblastic sarcoma (AMFS) is a rare low-grade sarcoma with somewhat unique morphologic characteristics. While recurrences are relatively common, distant metastases are infrequent. Cytopathologic descriptions of AMFS are limited, prompting the current study. Methods: A retrospective review was performed at two tertiary-care hospitals, and 3 patients with this diagnosis were identified. The cytopathologic and clinical features were reviewed. The following clinical data was collected for each case: age, gender, site of lesion, treatment, and follow-up information. Results: Pertinent cytologic features included large atypical epithelioid cells with occasional macronucleoli and lipoblast-like features in a background of bland spindle cells, myxoid stroma, and inflammation. All patients presented with acral mass lesions. Metastatic disease to an inguinal lymph node was found in 1 patient. Conclusions: AMFS is a low-grade sarcoma which shows some characteristic cytologic features. However, due to the presence of occasional bizarre and pleomorphic giant cells, there can be overlap with higher-grade sarcomas, and correlation with histology, immunohistochemistry, and imaging are required to make this diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acral Myxoinflammatory Fibroblastic Sarcoma: Cytopathologic Findings on Fine-Needle Aspiration

2013

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Report of two cases of myxoinflammatory fibroblastic sarcomas with preceding hematolymphoid neoplasms: Is there any association?

Aminparast

Sadeghi

Ramezani

2022

Clinical Case Reports

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Fine needle aspiration cytology findings of myxoinflammatory fibroblastic sarcoma: A case report

Ozaki

Kasashima

Kawashima

et al. 2017

Diagnostic Cytopathology

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Myxoinflammatory fibroblastic sarcoma (MIFS) is rare low-grade soft-tissue tumor that occurs in extremities. Clinically it is difficult to differentiate from benign lesions, such as nodular fasciitis, and malignant tumors, such as liposarcoma. We report a case of MIFS in the forearm of a 34-year-old man. The resected tumor measured 5.3 × 2.7 × 2.5 cm , had a lobular structure with indistinct boundary, and consisted of a large amount of translucent and yellow mucous-like substrate. Cytological examination of a preoperative puncture aspiration specimen showed histiocyte- and fibroblast-like tumor cells in a mucous-like matrix together with scattered lipoblast- and ganglion-like cells. Nuclear chromatin of the tumor cells showed a fine granular appearance but no notable hyperchromasia. There were no clear malignant findings. On Giemsa staining of the tumor cells, there were fine granular and hyaline intracytoplasmic substances that showed purple to reddish-purple metachromaticity. Prominent inflammatory cells were not observed in the specimens. MIFS should be considered in the differential diagnosis for a myxoid tumor in the extremities.

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Myxoinflammatory Fibroblastic Sarcoma: A Case Report and Review of the Literature

Cited by 14 publications

References 7 publications

Acral Myxoinflammatory Fibroblastic Sarcoma: Cytopathologic Findings on Fine-Needle Aspiration

Acral Myxoinflammatory Fibroblastic Sarcoma: Cytopathologic Findings on Fine-Needle Aspiration

Report of two cases of myxoinflammatory fibroblastic sarcomas with preceding hematolymphoid neoplasms: Is there any association?

Fine needle aspiration cytology findings of myxoinflammatory fibroblastic sarcoma: A case report

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