N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test

Park, Yongsoon; Moon, Hyoun-Jung; Kim, Seok-Hyeon

doi:10.1016/j.jnutbio.2011.04.018

Cited by 51 publications

(33 citation statements)

References 33 publications

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“…It has been reported that women are more vulnerable to depression than men [6], and the relationship between n-3 PUFA consumption and the risk of depression was only found in women in epidemiological studies [15][16][17]. Our previous study consistently reported that n-3 PUFAs increased climbing and decreased immobility in male rats [5].…”

Section: Discussionmentioning

confidence: 61%

“…The fatty acid composition of the brain tissue was measured as previously described [5]. The brain tissue (100 mg) was homogenized with 5 ml of chloroform:methanol:distilled water (2:2:1 v/v).…”

Section: Gas Chromatographymentioning

confidence: 99%

“…N-3 PUFA alters the fluidity of neuronal membranes and modulates the activities of signaling pathways through the expression of brain-derived neurotrophic factor (BDNF) and synaptogenesis [4]. Our previous study showed that n-3 PUFAs decreased cytokines and increased cyclic AMP response element binding protein (CREB) in rats [5]. Thus, insufficient intake of n-3 PUFAs could increase the susceptibility to psychiatric disorders, especially depression [3,5].…”

Section: Introductionmentioning

confidence: 99%

“…Our previous study showed that n-3 PUFAs decreased cytokines and increased cyclic AMP response element binding protein (CREB) in rats [5]. Thus, insufficient intake of n-3 PUFAs could increase the susceptibility to psychiatric disorders, especially depression [3,5].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

N-3 polyunsaturated fatty acids and 17β-estradiol injection induce antidepressant-like effects through regulation of serotonergic neurotransmission in ovariectomized rats

Jin

Park

2015

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 61%

Section: Gas Chromatographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

N-3 polyunsaturated fatty acids and 17β-estradiol injection induce antidepressant-like effects through regulation of serotonergic neurotransmission in ovariectomized rats

Jin

Park

2015

The Journal of Nutritional Biochemistry

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“…Fish is rich in n-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA; 20:5n3) and docosahexaenoic acid (DHA; 22:6n3), which are important in the development and maintenance of the central nervous system [6]. N-3 PUFAs have been shown to suppress eicosanoids and cytokines, which activate the downstream target brain-derived neurotrophic factor [7,8]. Previously, we reported that the erythrocyte levels of n-3 PUFAs were negatively associated with concentrations of tumor necrosis factor-α, thiobarbituric acid reactive substances, and nitrotyrosine in depressed Korean patients [9].…”

Section: Introductionmentioning

confidence: 99%

Supplementation of n-3 Polyunsaturated Fatty Acids for Major Depressive Disorder: A Randomized, Double-Blind, 12-Week, Placebo-Controlled Trial in Korea

Park

Kim

et al. 2015

Ann Nutr Metab

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Background: Controversy over the efficacy of n-3 polyunsaturated fatty acids (PUFAs) in depression continues to this day. The present study investigated the hypothesis that n-3 PUFA supplementation reduces depressive symptoms in Korean patients with major depressive disorder. Methods: In a randomized, double-blind, placebo-controlled, 12-week, parallel-group trial, 35 patients with Center for Epidemiological Studies Depression Scale Korean version (CES-D-K) scores ≥25 and depression confirmed by a psychiatrist were assigned to take either 3 capsules of n-3 PUFAs (1,140 mg of EPA + 600 mg of DHA; n = 18) or placebo (olive oil + safflower oil; n = 17). Results: Supplementation with n-3 PUFAs significantly reduced Clinical Global Impression Improvement (CGI-I) scores as compared with intake of placebo using intention-to-treat analysis with last-observation-carried-forward after adjusting for energy, fat, and fish intake. However, the CES-D-K, Hamilton Depression Rating Scale-17, and Clinical Global Impression Scale scores did not significantly differ between the n-3 PUFA and placebo groups. After supplementation with n-3 PUFAs, the erythrocyte levels of n-3 PUFAs were significantly increased, but n-6 PUFA levels were decreased. Conclusions: n-3 PUFAs demonstrated an advantage over placebo that did not reach clinical significance, although CGI-I score was significantly decreased in the n-3 PUFA group as compared with the placebo group.

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n‐3 polyunsaturated fatty acids improve depression‐like behavior by inhibiting hippocampal neuroinflammation in mice via reducing TLR4 expression

Zeng

Yang

et al. 2022

Immunity Inflam & Disease

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Introduction n‐3 polyunsaturated fatty acids (PUFAs) are believed to be implicated in the pathogenesis of many inflammation‐related diseases, including depression. Methods The mouse model of depression was established through chronic unpredictable mild stress (CUMS), the mice were intervened with n‐3 PUFAs, and then the expression of toll‐like receptor 4 (TLR4) was stimulated with lipopolysaccharides (LPS). Tail suspension test (TST), forced swimming test (FST) and sucrose preference test were performed to monitor the depression behavior of mice. Microglia activation was detected by Iba1 immunofluorescence, and neuronal injury was detected by Nissl staining. Concentrations of tumor necrosis factor (TNF)‐α, Interleukin (IL)‐6 and IL‐1β in the hippocampus were assessed via enzyme linked immunosorbent assay (ELISA). Quantitative real time polymerase chain reaction was used to detect IL‐6, IL‐1β and TNF‐α messenger RNA levels. Western blot was utilized for detection of TLR4 protein expression. Results CUMS significantly reduced the sucrose preference in mice, while increased the immobility time in FST and TST. Moreover, CUMS significantly aggravated microglia activation and neuronal damage in mice and increased the levels of IL‐6, IL‐1β and TNF‐α in hippocampal tissues, however, intervention with n‐3 PUFAs could improve the above effects. Further, the increased TLR4 induced by LPS partially reversed the inhibition of n‐3 PUFAs on depression‐like behaviors, microglial activation and inflammatory injury of hippocampal neurons. Conclusion n‐3 PUFAs may ameliorate depression‐like behaviors via reducing hippocampal neuroinflammation in CUMS‐induced mice by regulating TLR4 expression, suggesting that n‐3 PUFAs may be an effective antidepressant, which provides evidence for future treatment of depression.

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N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test

Cited by 51 publications

References 33 publications

N-3 polyunsaturated fatty acids and 17β-estradiol injection induce antidepressant-like effects through regulation of serotonergic neurotransmission in ovariectomized rats

N-3 polyunsaturated fatty acids and 17β-estradiol injection induce antidepressant-like effects through regulation of serotonergic neurotransmission in ovariectomized rats

Supplementation of n-3 Polyunsaturated Fatty Acids for Major Depressive Disorder: A Randomized, Double-Blind, 12-Week, Placebo-Controlled Trial in Korea

n‐3 polyunsaturated fatty acids improve depression‐like behavior by inhibiting hippocampal neuroinflammation in mice via reducing TLR4 expression

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