N-3 polyunsaturated fatty acids reduces post-operative atrial fibrillation incidence in patients undergoing “on-pump” coronary artery bypass graft surgery

Abstract

N-3 polyunsaturated fatty acids administration significantly reduces the incidence of post-operative atrial fibrillation in patients undergoing "on-pump" coronary artery bypass graft surgery. N-3 polyunsaturated fatty acids therapy is not associated with a shorter hospital stay.

Antioxidant Supplementation Attenuates Oxidative Stress in Patients Undergoing Coronary Artery Bypass Graft Surgery

“…This is consistent with results of our study, although not significant: in both studies the mean duration of AF was reduced. This finding contradicts other studies, which reported significant reductions of post-operative AF by administration of n-3 PUFAs (Mori et al 2003;Sorice et al 2011). The discrepancy might be explained by the fact that patients with low baseline n-3 PUFAs levels may benefit disproportionately from DHA and EPA substitutions (Skuladottir et al 2011).…”

“…Such divergent results could, however, be attributed to limited study populations. Indeed, the population of the present pilot-study comprised only 20% compared to (Sorice et al 2011). Last but not least we observed a prolonged operation time, cross-clamp time and extracorporeal circulation for Vit-n-3 PUFAs patients compared to Vit subjects that might have adversely affected the therapeutic effect in this subgroup.…”

EPA and DHA increased PPARγ expression and deceased integrin-linked kinase and integrin β1 expression in rat glomerular mesangial cells treated with lipopolysaccharide

“…Fish oil, a type of PPARγ natural ligand, has been reported to slow the progress of kidney disease. A diet rich in n-3 PUFA, like EPA and DHA, has been associated with reduced triacylglycerol (TAG) levels, anti-infl ammatory action, pulmonary disease (9), and a lowered risk of cardiovascular disease and mortality (10)(11)(12)(13). A higher dietary intake of PUFA may protect against progression of chronic kidney disease (14).…”

Do Omega-3 Polyunsaturated Fatty Acids Prevent Atrial Fibrillation?

“…Atrial fibrillation (AF) is a rhythm disturbance commonly encountered in patients recovering from open-heart surgery as well as in the population as a whole. This rhythm disturbance increases patient morbidity following open-heart surgery [2]. PUFAs are well tolerated, and several studies have reported that they have a possible beneficial effect in reducing AF [2,3,4].…”

“…This rhythm disturbance increases patient morbidity following open-heart surgery [2]. PUFAs are well tolerated, and several studies have reported that they have a possible beneficial effect in reducing AF [2,3,4]. Investigators have implicated the anti-inflammatory properties of PUFAs and their integral role in cell membrane function (e.g.…”