N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate–resistant patients with polycystic ovary syndrome

RETRACTED: Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial

“…The introduction of antioxidant therapy to ovarian stimulation was proven to have many benefits regarding cell mitosis and apoptosis (1,2). N-acetyl cysteine, as an antioxidant, has been suggested as an adjuvant in clomiphene-resistant cases (3,4).…”

N-acetyl cysteine vs. metformin in treatment of clomiphene citrate–resistant polycystic ovary syndrome: a prospective randomized controlled study

“…In the present study, ovulation occurred in 16 patients (51.6%) in the MET group vs. in 2 (6.6%) in the NAC group, indicating the superiority of MET over NAC. N-Acetyl cysteine may be an adjuvant to CC; Rizk et al (12) showed that the combination of NAC (1.2 g/d) with CC (100 mg/d) for 5 days significantly increased both ovulation and pregnancy rates in obese women with CC-resistant PCOS (49.3% vs. 1.3% and 21.3% vs. 0, respectively). These results were not confirmed by other studies.…”

“…In 2004, Rizk et al (12) showed that the combination of CC and NAC significantly increased both ovulation and pregnancy rate in women with CC-resistant PCOS. To our knowledge, the role of NAC alone in inducing ovulation in CC-resistant PCOS was never evaluated.…”

Oxidative stress in pregnancy and fertility pathologies

“…I n ter e stin gly e nou g h , t he a n tio x i d a nt Nacetylcysteine was found to be a safe and welltolerated adjuvant to clomiphene citrate for improvement of ovulation and pregnancy rates in PCOS patients (Badawy et al 2007;Nasr 2010;Rizk et al 2005;Salehpour et al 2012). Moreover, controlledrelease alpha lipoic acid has positive effects on PCOS phenotype, although its effects may be exerted through a mechanism not involving changes in oxidative stress (Masharani et al 2010).…”