N-acetyltransferase 2 polymorphism is associated with bladder cancer risk: An updated meta-analysis based on 54 case-control studies

Song, Yuxuan; Qi, Xiangjie; Liu, Xiaoqiang

doi:10.1016/j.gene.2020.144924

Cited by 14 publications

(5 citation statements)

References 66 publications

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“…25 In addition, smokers with the slow NAT2 genotype had higher BCa risk than smokers with the fast/intermediate NAT2 genotype. 25 Of note, the frequency of NAT2 genotypes differed between ethnic groups: the slow genotype accounted for 59% of individuals in Europe but was much less frequent in Northeast Asian countries (China, Japan, Korea), accounting for 18% of individuals on average. 26 This low prevalence of Previous epidemoiological studies consistently showed that smoking cessation results in a decrease in BCa risk, consistent with our present findings.…”

Section: Discussionmentioning

confidence: 98%

“…A meta-analysis indicated that the NAT2 slow genotype was associated with increased risk of BCa in Asian as well as Western populations. 25 In addition, smokers with the slow NAT2 genotype had higher BCa risk than smokers with the fast/intermediate NAT2 genotype. 25 Of note, the frequency of NAT2 genotypes differed between ethnic groups: the slow genotype accounted for 59% of individuals in Europe but was much less frequent in Northeast Asian countries (China, Japan, and Korea), accounting for 18% of individuals on average.…”

Section: Discussionmentioning

confidence: 98%

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Cigarette Smoking, Smoking Cessation, and Bladder Cancer Risk: A Pooled Analysis of 10 Cohort Studies in Japan

Masaoka

Matsuo

Oze

et al. 2023

Journal of Epidemiology

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Cigarette Smoking, Smoking Cessation, and Bladder Cancer Risk: A Pooled Analysis of 10 Cohort Studies in Japan

Masaoka

Matsuo

Oze

et al. 2023

Journal of Epidemiology

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“…In conclusion, there is a considerable number of studies that indicate a significant association between the increased BCa and PCa risks and susceptibility genes in the general population [63][64][65][66].…”

Section: Discussionmentioning

confidence: 99%

Gene-occupation interactions: a review of the literature on bladder and prostate cancer

Wieczorek¹,

Wolniakowska²,

Roszak³

et al. 2023

Med Pr

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Bladder cancer (BCa) and prostate cancer (PCa) are genitourinary cancers which constitute significant health problems in men and in which environmental factors play an important role. Understanding the genetic susceptibility to BCa or PCa and occupational exposure is paramount to improving cancer prevention and early detection. The aim of this review article was to address the scientific evidence on the genetic risk factors and occupational exposure associated with the occurrence of BCa and PCa. The authors identified relevant original articles that have been published between 1994 and 2023. Variations of the following search terms: "gene" and "occupational" combined with one of the following terms: "bladder cancer" or "prostate cancer" were applied for the search purpose. The authors found 342 publications of which 50 population studies met their requirements for gene-occupation interactions. In total, 34 full-text manuscripts were about BCa and 16 about PCa. These research examines the genes involved in detoxification processes of xenobiotics (glutathione S-transferase, N-acetyltransferase, cytochrome P450, UDP-glucuronosyltransferase), oxidative stress (glutathione peroxidase 1, manganese superoxide dismutase, catalase), altering DNA repair capacity (X-ray repair cross-complementing 1, base excision repair, nucleotide excision repair), tumour suppression (TP53 gene), and vitamin D pathway (vitamin D receptor gene). The role of genetic factors in the occupational exposure has not been conclusively established, but it appears the possibility of genetic involvement. Determination of environmentally responsive genes provides important mechanistic implications for the etiology of occupational cancers, and valuable input in occupational exposure limits set by taking genetic susceptibility into account. More genetic research is needed to corroborate these findings and assess their significance in the workplace.

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“…У МА 54 досліджень «випадок-контроль» (що включали 31 929 хворих) повільне ацетилування генотипу NAT-2 було пов'язано з підвищеним ризиком РСМ порівняно з генотипами із швидким та помірним ацетилуванням (ВШ: 1,46; 95% ДІ: 1,30-1,63) [99]. N-ацетілтрансфераза-2-ген (NАТ-2) бере участь у фазі II детоксикації ароматичних моноамінів [100].…”

Section: взаємодія генотипу та оточуючого середовищаunclassified

Epidemiology of Bladder Cancer: Current Insight

Golovko

2024

ЗЧ

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Bladder cancer (BC) is a 9th most common cancer in the world that make from 3% of global neoplasms. Bladder cancer is prevalent in the developed countries. Cancer of the bladder is four times more common in men than women. External risk factors and internal triggers contribute to the development of bladder cancer. Thus, comprehensive analysis of these risk factors is a earnest to timely prevention of indicated oncologic pathology. The objective: to do a current systematic review of epidemiology of bladder cancer and modern important risk factors, which appropriate to the given pathology. Evidence acquisition. We carried out a systemic review of epidemiology of bladder cancer embracing PubMed and Embase including March 2023. All studies reporting gender, smoking, E-cigarette use, opium consumption, occupational carcinogene expose, dietary factors, race, gene-environment interaction, socioeconomic status. Microbiome factors, urolithiasis, benign prostate hyperplasiapelvic radiotherapy were excluded. Evidence synthesis. A total of 516 papers, that studied epidemiology of bladder cancer, were involved. According to GLOBOCAN, there were 573 000 new bladder cancer cases and 213 000 deaths worldwide in 2020. Smoking and occupational exposures (aromatic amines and polycyclic aromatic hydrocarbons) are the most important risk factors. Moreover, the additional risk factors include some dietary agents, gene specificities, diesel exhaust emissions and etc. Conclusions. Smoking tobacco and specific occupational exposures are the most important risk factors. Prevention strategies, including smoke cessation, responsible workplace safety, diet, schistosomias prevention are useful for reduction of the incidence BC. But high-quality studies are required to confirm initial results that will support timely prevention of BC.

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N-acetyltransferase 2 polymorphism is associated with bladder cancer risk: An updated meta-analysis based on 54 case-control studies

Cited by 14 publications

References 66 publications

Cigarette Smoking, Smoking Cessation, and Bladder Cancer Risk: A Pooled Analysis of 10 Cohort Studies in Japan

Cigarette Smoking, Smoking Cessation, and Bladder Cancer Risk: A Pooled Analysis of 10 Cohort Studies in Japan

Gene-occupation interactions: a review of the literature on bladder and prostate cancer

Epidemiology of Bladder Cancer: Current Insight

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