N-Acyl taurines trigger insulin secretion by increasing calcium flux in pancreatic β-cells

Taurine and cardiac disease: state of the art and perspectives

“…Several indirect and few direct studies on the short-and long-term effects of taurine under normal physiological and pathological condi-tions showed opposing results concerning the regulation of intracellular Na + and Ca 2+ homeostasis by taurine. Some work in the field has shown that taurine induces, in certain conditions, an increase in intracellular Ca 2+ (Sperelakis et al 1992;Takahashi et al 1992;Palmi et al 1996;Bkaily et al 1996;Cuttitta et al 2013;Waluk et al 2013) and in other conditions, a decrease in intracellular Ca 2+ (Bkaily et al 1996;Ghosh et al 2009;Abebe and Mozaffari 2011;Wang et al 2018). This controversy in the literature regarding the effect of taurine on Ca 2+ homeostasis may be due to the duration of treatment (short versus long term) with taurine as well as the presence or absence of cardiac pathology (Bkaily et al 1997).…”

Sulfate-based lipids: Analysis of healthy human fluids and cell extracts

“…SDS). Taurine-lipids were also proposed as fatty acid amid hydrolase (FAAH) inhibitors (Long et al, 2011;Saghatelian et al, 2006), anti-proliferative effect in prostate cancer cell line (Chatzakos et al, 2012); increase insulin secretion (Waluk et al, 2013) and activation of transient receptor potential (TRP) calcium channels (Saghatelian et al, 2006) supporting the need for additional screening studies in fluids and cells.…”

N‐Acyl amino acids and their impact on biological processes

“…Treatment of pancreatic β‐cell lines with N ‐arachidonoyl taurine and N ‐oleoyl taurine resulted in a significant increase in insulin secretion . This treatment led to an increase of intracellular Ca 2+ ions and directly activated insulin release from the pancreatic cells.…”