N-benzyl derivatives of valine esters

Abstract

The reactions of methyl and ethyl esters of valine with m-bromobenzaldehyde and p-chlorobenzaldehyde in absolute methanol in the presence of magnesium sulfate yielded the corresponding azomethines (CH 3 ) 2 CHCH(COOR 1 )N=CHR 2 (R 1 = CH 3 , C 2 H 5 ; R 2 = 3-BrC 6 H 4 , 4-ClC 6 H 4 ); their reduction with sodium borohydride gave N-benzyl derivatives of valine esters, (CH 3 ) 2 CHCH(COOR 1 )NHCH 2 R 2 .