N-halamine-decorated polystyrene nanoparticles based on 5-allylbarbituric acid: From controllable fabrication to bactericidal evaluation

Dong, Alideertu; Huang, Zhen; Lan, Shi; Wang, Qin; Bao, Sarina; Siriguleng,; Zhang, Yanling; Gao, Ge; Liu, Fengqi; Harnoode, Chokto

doi:10.1016/j.jcis.2013.09.036

Cited by 51 publications

(34 citation statements)

References 54 publications

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“…In contrast to conventional antibiotics, the biomaterials sector has witnessed the genesis of various kinds of innovative antimicrobial agents (Regiel‐Futyra et al, ). Materials like peptides (Marr, Gooderham, & Hancock, ; Meher, Sahu, Saini, & Rao, ), zinc/zinc oxide (ZnO) (Bhattacharjee et al, ; Cai et al, ; Raghupathi, Koodali, & Manna, ), N‐halamines (Dong et al, ; Kang et al, ), quaternary ammonium salt (Munoz‐Bonilla & Fernández‐García, ; Timofeeva & Kleshcheva, ) and povidone−iodine (PVP − I 2 ) (Gao, Wang, Liu, & Du, ) have been effectively used to treat surgical site infections (SSI) in orthopedics (Gao et al, ). However, compared with antibiotics and other antibacterial agents, silver (Ag) is recognized as a universal and traditional bactericidal agent that has shown a useful bactericidal effect on a broad spectrum of microbial species over decades (Chernousova & Epple, ).…”

Section: Introductionmentioning

confidence: 99%

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

et al. 2019

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This article reports for the first time our successful result in the synthesis of antibacterial single‐phase newberyite (NB, MgHPO4.3H2O), an important magnesium phosphate (MgP) bioceramic. The prime novelty lies in the fact that we explore novel MgPs as next‐generation orthopedic biomaterials as opposed to conventional calcium phosphates (CaP). While NB has already shown great promise, unlike its competitor struvite (ST, MgNH4PO4.6H2O), NB is not intrinsically antibacterial. Given the havoc created by surgical site infections (SSI) in orthopedics, it would be worthwhile to explore if antibacterial NB can be synthesized cost‐effectively. To accomplish that central goal, we used silver ion (Ag+) containing precursor solutions and exposed those to microwave irradiation. This action resulted in the rapid synthesis of NB microplatelets. Besides, three other specific objectives are addressed. First, Ag‐doping was optimized to preserve the single‐phase nature for sustained dopant release. Second, Ag+ release kinetics against common infection causing bacterial strains was analyzed. Finally, we inspected for any harmful effect of Ag‐doped NB on MC3T3 preosteoblasts. Interestingly, the single‐phase nature of NB microplatelets can be retained until 2 wt % Ag‐doping and they exhibit good antibacterial and cytocompatible properties. Even though 3 wt % Ag‐doped compositions (composites) were 100% antibacterial; they were cytotoxic.

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Section: Introductionmentioning

confidence: 99%

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

et al. 2019

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“…Surface modification of polymers with antibacterial groups such as N ‐halamines, quaternary ammonia salts, and heavy‐metal ions is an efficient means to avoid the growth of microorganisms and provide extended applications in biomaterials and daily life. PE is the most commonly used plastic due to its many attractive properties including flexibility, nontoxicity, high strength, and chemical stability.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of polysiloxane with 5,5‐dimethylhydantoin‐based N‐halamine pendants for biocidal functionalization of polyethylene by supercritical impregnation

Chen

Zhang

Han

et al. 2017

J of Applied Polymer Sci

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An N‐halamine precursor 3‐(3‐hydroxypropyl)‐5,5‐dimethylhydantoin (HPDMH) has been synthesized. The N‐halamine precursor was reacted with poly(methylhydrosiloxane) (PMHS) to produce a biocidal polysiloxane with 5,5‐dimethylhydantoin‐based N‐halamine pendants through silane alcoholysis and subsequent chlorination of hydantoin ring with tert‐butyl hypochlorite. The N‐halamine polysiloxane was impregnated into inert polyethylene (PE) fibers and formed a 68‐nm coating layer in supercritical carbon dioxide (scCO2) for antibacterial application. The PE fibers before and after impregnation were characterized by XPS and SEM. The N‐halamine polysiloxane impregnated PE samples provided effective biocidal activities against both Staphylococcus aureus and Escherichia coli compared with unmodified ones that did not display obvious antibacterial activities. The coating layer on PE substrate was stable toward washing cycles, storage, and UV irradiation and the rechargeability of lost active chlorines was good. The scCO2 impregnation approach uses environmentally friendly CO2 as solvent and can be applied to both reactive and nonreactive substrates since it does not require covalent bonds to tether biocidal moieties. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44721.

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“…N ‐halamines contain one or more nitrogen‐halogen covalent bonds, and their positive oxidative halogen can be transferred directly to bacterial cells leading to the inactivation of the bacteria through destruction or inhibition of metabolic processes in the microorganisms . In past decades a variety of N ‐halamine compounds have been investigated and applied in medical devices, textiles, hospitals, water purification systems, food packaging, food storage, and household sanitation to produce antibacterial materials .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial silica and sand particles functionalized with an N‐halamine acrylamidesiloxane copolymer

Jiang

Demir

Broughton

et al. 2016

J of Applied Polymer Sci

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The monomer 2-acrylamido-2-methyl-1-(5-methylhydantoinyl)propane (HA) was copolymerized with 3-(trimethoxysilyl)propyl methacrylate (SL) and covalently attached onto silica gel and sand particles. As a result HASL copolymer-grafted silica gel and sand particles (HASL SGPs and SPs) were obtained. These two types of HASL SGPs and SPs provided excellent biocidal efficacy against Gram positive S. aureus and Gram negative E. coli O157:H7 bacteria when the copolymer-grafted particles were exposed to dilute sodium hypochlorite (household bleach) solution. In a flowing water application, seven logs of bacteria were inactivated within 10 s of contact time with the particles packed into a column. The treated particles also exhibited good washing and storage stabilities. The chlorine loss during extensive flow could be recovered by further exposure to dilute bleach solution. The antimicrobial particles have potential application for use in inexpensive disinfecting water filters for slow water flows. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43413.

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N-halamine-decorated polystyrene nanoparticles based on 5-allylbarbituric acid: From controllable fabrication to bactericidal evaluation

Cited by 51 publications

References 54 publications

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

Synthesis of polysiloxane with 5,5‐dimethylhydantoin‐based N‐halamine pendants for biocidal functionalization of polyethylene by supercritical impregnation

Antimicrobial silica and sand particles functionalized with an N‐halamine acrylamidesiloxane copolymer

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