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            -Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication

Khan, Owais; Tanuj, Gunturu Narasimha; Choravada, Divyaprakash R; Rajak, Kaushal Kishor; Sekar, S. Chandra; Lingaraju, Madhu Cholenahalli; Dhara, Sujoy K.; Gupta, Praveen Kumar; Mishra, Bishnu Prasad; Dutt, Triveni; Gandham, Ravi Kumar; Sajjanar, Basavaraj

doi:10.1128/spectrum.02666-22

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Cited by 2 publications

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“…Interestingly, a decrease in m6A level caused by FTO also leads to a decrease in PPRV replication. This suggests an optimal level of m6A modification is required for PPRV replication and in case the level changes beyond the threshold, a decrease in PPRV replication is inevitable [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in m6A RNA methylation of goat lung following PPRV infection

Nabi Khan,

Praharaj,

Malla

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Changes in m6A RNA methylation of goat lung following PPRV infection

Nabi Khan,

Praharaj,

Malla

et al. 2023

Heliyon

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When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?

Wang,

Jin,

Xie

et al. 2024

Vet Res

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N6-methyladenosine (m6A) is a prevalent and dynamic RNA modification, critical in regulating gene expression. Recent research has shed light on its significance in the life cycle of viruses, especially animal viruses. Depending on the context, these modifications can either enhance or inhibit the replication of viruses. However, research on m6A modifications in animal virus genomes and the impact of viral infection on the host cell m6A landscape has been hindered due to the difficulty of detecting m6A sites at a single-nucleotide level. This article summarises the methods for detecting m6A in RNA. It then discusses the progress of research into m6A modification within animal viruses’ infections, such as influenza A virus, porcine epidemic diarrhoea virus, porcine reproductive, and respiratory syndrome virus. Finally, the review explores how m6A modification affects the following three aspects of the replication of animal RNA viruses: the regulation of viral genomic RNA function, the alteration of the m6A landscape in cells after viral infection, and the modulation of antiviral immunity through m6A modification. Research on m6A modifications in viral RNA sheds light on virus-host interactions at a molecular level. Understanding the impact of m6A on viral replication can help identify new targets for antiviral drug development and may uncover novel regulatory pathways that could potentially enhance antiviral immune responses.

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N ⁶ -Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication

Abstract: Peste des petits ruminants virus (PPRV) causes a severe disease in sheep and goats. PPRV infection is a major problem, causing significant economic losses to small ruminant farmers in regions of endemicity.

Cited by 2 publications

References 48 publications

Changes in m6A RNA methylation of goat lung following PPRV infection

Changes in m6A RNA methylation of goat lung following PPRV infection

When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?

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N 6 -Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication

Abstract: Peste des petits ruminants virus (PPRV) causes a severe disease in sheep and goats. PPRV infection is a major problem, causing significant economic losses to small ruminant farmers in regions of endemicity.

Cited by 2 publications

References 48 publications

Changes in m6A RNA methylation of goat lung following PPRV infection

Changes in m6A RNA methylation of goat lung following PPRV infection

When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?

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Product

Resources

About

N ⁶ -Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication