N-terminal pro-brain natriuretic peptide and cardiac troponin I for the prognostic utility in elderly patients with severe sepsis or septic shock in intensive care unit: A retrospective study

Cheng, Hui; Fan, Wei; Wang, Sheng-Chi; Liu, Zhaohui; Zang, Hui-Ling; Wang, Zhen; Liu, Hongjuan; Shen, Xiaohui; Liang, Shao-Qing

doi:10.1016/j.jcrc.2014.12.008

Cited by 40 publications

(33 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, NT-pro-BNP was a better predictive marker than hs-cTnT for mortality in the ICU and at 90 days (41). Similar results previously have been found in smaller studies (43, 44). …”

Section: Clinical Chemistrysupporting

confidence: 92%

Diagnosing sepsis – The role of laboratory medicine

Fan¹,

Miller²,

Lee³

et al. 2016

Clinica Chimica Acta

141

100

View full text Add to dashboard Cite

Sepsis is the host response to microbial pathogens resulting in significant morbidity and mortality. An accurate and timely diagnosis of sepsis allows prompt and appropriate treatment. This review discusses laboratory testing for sepsis because differentiating systemic inflammation from infection is challenging. Procalcitonin (PCT) is currently an FDA approved test to aid in the diagnosis of sepsis but with questionable efficacy. However, studies support the use of PCT for antibiotic de-escalation. Serial lactate measurements have been recommended for monitoring treatment efficacy as part of sepsis bundles. The 2016 sepsis consensus definitions include lactate concentrations greater than 2 mmol/L (>18 mg/dL) as part of the definition of septic shock. Also included in the 2016 definitions are measuring bilirubin and creatinine to determine progression of organ failure indicating worse prognosis. Hematologic parameters, including a simple white blood cell count and differential, are frequently part of the initial sepsis diagnostic protocols. Several new biomarkers have been proposed to diagnose sepsis or to predict mortality, but they currently lack sufficient sensitivity and specificity to be considered as stand-alone testing. If sepsis is suspected, new technologies and microbiologic assays allow rapid and specific identification of pathogens. In 2016 there is no single laboratory test that accurately diagnoses sepsis.

show abstract

“…Furthermore, NT-pro-BNP was a better predictive marker than hs-cTnT for mortality in the ICU and at 90 days (41). Similar results previously have been found in smaller studies (43, 44). …”

Section: Clinical Chemistrysupporting

confidence: 92%

Diagnosing sepsis – The role of laboratory medicine

Fan¹,

Miller²,

Lee³

et al. 2016

Clinica Chimica Acta

141

100

View full text Add to dashboard Cite

show abstract

“…52,53 Biomarkers including cardiac troponin I and N-terminal pro-brain natriuretic peptide (NT-proBNP) may also have a role in predicting mortality in elders with severe sepsis or septic shock. 54,55 …”

Section: Severe Sepsis and Septic Shockmentioning

confidence: 99%

Sepsis and Other Infectious Disease Emergencies in the Elderly

Liang

2016

Emergency Medicine Clinics of North America

View full text Add to dashboard Cite

“…Of the 46 studies included in this review, 35 examined the association of brain natriuretic peptides (BNP, NT‐proBNP) with survival in patients with septic shock, presented in Table . The vast majority were prospective cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…This association was also evaluated by two studies in the setting of an RCT evaluating the use of 20% human albumin plus crystalloids or crystalloids alone in patients with severe sepsis or septic shock . In total, 30 studies, including the two conducted in the setting of the RCT, have found a significant association between elevated levels of brain natriuretic peptides and increased mortality …”

Section: Resultsmentioning

confidence: 99%

The utility of brain natriuretic peptides in septic shock as markers for mortality and cardiac dysfunction: A systematic review

et al. 2019

View full text Add to dashboard Cite

Objective To conduct a systematic review evaluating the utility of brain natriuretic peptide (BNP) and N‐terminal proBNP (NT‐proBNP) as biomarkers in adult patients with septic shock. Materials and Methods Pubmed/Medline databases were searched from inception to November 2018 using the search terms: (septic[Title/Abstract] AND shock[Title/Abstract]) AND bnp[Title/Abstract]) and (septic[Title/Abstract]) AND shock[Title/Abstract]) AND natriuretic[Title/Abstract]). No restriction was applied regarding date of publication. Comparative observational studies evaluating BNP and NT‐proBNP in patients with septic shock aged ≥18 years were eligible for inclusion. Bibliographies from the extracted articles were also reviewed to identify additional relevant publications. Results In total, 46 studies met all eligibility criteria and were included. A strong body of literature has demonstrated that in patients with septic shock, increased values of BNP and NT‐proBNP are associated with increased mortality. An increase from baseline BNP values has also been associated with increased mortality, whereas decreases from baseline values are not related to worse outcome. Brain natriuretic peptides have also been associated with cardiac dysfunction in patients with sepsis. Moreover, BNP values have been found to be significantly elevated in septic shock, regardless of cardiac dysfunction, and have been used to distinguish between septic and cardiogenic shock. Furthermore, BNP and NT‐proBNP are significantly increased in patients with septic shock, compared to patients with sepsis and severe sepsis. Conclusions BNP and NT‐proBNP appear to be reliable predictors of outcome in septic shock.

show abstract

N-terminal pro-brain natriuretic peptide and cardiac troponin I for the prognostic utility in elderly patients with severe sepsis or septic shock in intensive care unit: A retrospective study

Cited by 40 publications

References 49 publications

Diagnosing sepsis – The role of laboratory medicine

Diagnosing sepsis – The role of laboratory medicine

Sepsis and Other Infectious Disease Emergencies in the Elderly

The utility of brain natriuretic peptides in septic shock as markers for mortality and cardiac dysfunction: A systematic review

Contact Info

Product

Resources

About