N-Type Ca Channel in Epileptic Syndromes and Epilepsy: A Systematic Review of Its Genetic Variants

Abstract

N-type voltage-gated calcium channel controls the release of neurotransmitters from neurons. The association of other voltage-gated calcium channels with epilepsy is well-known. The association of N-type voltage-gated calcium channels and pain has also been established. However, the relationship between this type of calcium channel and epilepsy has not been specifically reviewed. Therefore, the present review systematically summarizes existing publications regarding the genetic associations between N-type voltage-dependent calcium channel and epilepsy.

Is the regulation of lamotrigine on depression in patients with epilepsy related to cytokines?

“…The pathogenesis of epilepsy is not clear, and previous studies have suggested that seizures in epilepsy are related to structural changes, genetics, infection, metabolism and other reasons [ [3] , [4] , [5] ]. In 2017, immune factors were recognized as important causes of seizures by the International League against Epilepsy, and the role of autoimmune factors in the pathogenesis of epilepsy is gaining increasing attention [ 6 ].…”