Nadir CA-125 concentration in the normal range as an independent prognostic factor for optimally treated advanced epithelial ovarian cancer

Prat, Aleix; Parera, Marta; Peralta, Sergio; Pérez-Benavente, Asunción; García, Ángel; Martínez-Palones, José M.; Roxana, I.; Baselga, J.; Campo, J. M. Del

doi:10.1093/annonc/mdm495

Cited by 58 publications

(47 citation statements)

References 23 publications

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“…13 More recently, different nadir values and trends of elevated CA-125 values within the normal range have been shown to be prognostic of recurrence and survival in patients with ovarian cancer. [14][15][16][17][18] The objective of our study was to evaluate the clinical significance of rising CA-125 levels within the normal range (35 U/mL) in patients with UPSC.…”

Section: Introductionmentioning

confidence: 99%

The Clinical Relevance of Rising CA-125 Levels Within the Normal Range in Patients With Uterine Papillary Serous Cancer

et al. 2013

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The utility of cancer antigen 125 (CA-125) levels as an adjunct method of monitoring patients with uterine papillary serous carcinoma (UPSC) or endometrial serous carcinoma after surgery and adjuvant treatment has been reported. Our goal was to determine the significance of rising CA-125 levels within the normal range in these patients in the posttreatment surveillance setting. All patients with UPSC who underwent surgical staging and had preoperative CA-125 measurement from 1999 to 2008 were included in this analysis. Information was extracted from records to assess the changes in CA-125 values with clinical and/or radiographic detection of recurrence. Of the 56 evaluable patients, 23 (41%) recurred. Of the 23 patients that recurred, 11 had serial CA-125 levels measured in remission. Elevated CA-125 levels at diagnosis were significantly associated with disease recurrence and advanced stage (P ¼ .01, P ¼ .001, respectively). The rise in CA-125 by 10 U/mL in the normal range and 15 U/mL were associated with disease recurrence (P < .001, P < .001, respectively). In multivariate analysis, only CA-125 level 15 U/mL was significantly associated with worse progression-free survival. In this small cohort of patients with recurrent UPSC after remission, surveillance of CA-125 levels may have a role in disease surveillance and management.

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Section: Introductionmentioning

confidence: 99%

The Clinical Relevance of Rising CA-125 Levels Within the Normal Range in Patients With Uterine Papillary Serous Cancer

et al. 2013

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“…Therefore, many researchers have been investigating the role of maintenance or consolidation chemotherapy in patients who achieved complete remission (CR) [4,5]. Recently, it has been suggested that nadir serum CA-125 levels 10 U/ml are independently associated with progression free survival (PFS) in the patients with CR after first line therapy [6][7][8][9][10]. Based on these results, the researchers suggested the possibility of using the nadir CA-125 to define the population who may benefit from maintenance chemotherapy [6,8].…”

Section: Introductionmentioning

confidence: 99%

Nadir CA‐125 level is an independent prognostic factor in advanced epithelial ovarian cancer

Kang

Seo

Park

2009

Journal of Surgical Oncology

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“…Many studies indicate that serum Ca125 level nadir after chemotherapy completion may be a strong prognostic factor for progression free survival time as well as for OS [11,12,13] . It has been showed that women with nadir serum Ca125 lower than 10 U/mL live longer than women with higher nadir [14] . Ca125 regression after two cycles of neoadjuvant chemotherapy appears to be an important prognostic factor for probability of radical surgery and OS for OC patients [15] .…”

Section: Discussionmentioning

confidence: 99%

The Ca125 Concentration in Intraperitoneal Fluid as A Prognostic Factor in Ovarian Cancer Patients with Refractory Malignant Ascites

Nowara¹,

Badora-Rybicka²,

Swiderska³

et al. 2016

Journal of Tumor

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intravenous chemotherapy. An intraperitoneal chemotherapy was cisplatin based. Ca125 concentration was measured twice in intraperitoneal fluid: before intraperitoneal chemotherapy infusion and 24 hours after. RESULTS: Patients with Ca125 intraperitoneal concentration decrease more than 3 times lived longer than patients with lower Ca126 concentration reduction (78.5 vs 33,1 months), p = 0.06. The results of this study have many limitations, mostly due to the group of pts being small. That is why the results should be taken into consideration with caution. CONCLUSIONS: Intraperitoneal fluid Ca125 concentration decrease rate after intraperitoneal chemotherapy seems to be a prognostic factor for overall survival in ovarian cancer patients with refractory malignant ascites.

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Nadir CA-125 concentration in the normal range as an independent prognostic factor for optimally treated advanced epithelial ovarian cancer

Abstract: The CA-125 nadir value is a strong independent prognostic factor for optimally treated adEOC after achieving a complete response.

Cited by 58 publications

References 23 publications

The Clinical Relevance of Rising CA-125 Levels Within the Normal Range in Patients With Uterine Papillary Serous Cancer

The Clinical Relevance of Rising CA-125 Levels Within the Normal Range in Patients With Uterine Papillary Serous Cancer

Nadir CA‐125 level is an independent prognostic factor in advanced epithelial ovarian cancer

The Ca125 Concentration in Intraperitoneal Fluid as A Prognostic Factor in Ovarian Cancer Patients with Refractory Malignant Ascites

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