NADPH oxidase inhibitor development for diabetic nephropathy through water tank model

Abstract

Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell signaling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. Therefore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabetic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy.

Nox4-SH3YL1 complex is involved in diabetic nephropathy

“…ROS homeostasis is regulated from a balance between ROS generation and elimination in healthy condition. 52 , 53 The homeostasis in human body is similar with water balance in water tank. Just as a certain amount of water in tank remains when the inlet and outlet of water are maintained.…”

Simulation and Evaluation of Runoff in Tributary of Weihe River Basin in Western China

“…The water tank model (PD Tank) is also a conceptual runoff model, which uses various links of the hydrological process of watershed (flow generation, slope backflow, river confluence, etc.) to simulate several interconnected water tanks [27][28][29][30]. The SWAT model takes into account the complexity of the soil, land use, and management status in a watershed to conduct prediction and management analyses.…”

Diabetic kidney disease, revisited: where do we stand?

“…Tong and Adler [ 1 ] the comprehensive approach to the management of DKD to reduce the progression of renal disease and minimize the risk for cardiovascular events based on the latest published data. Lee et al [ 2 ] gives an overview of the role of NADPH oxidase in DKD, and offer a theoretical basis for the development of various Nox inhibitor as a regulator of reactive oxygen species homeostasis to provide an emerging new therapeutic approach for DKD. Pak et al [ 3 ] present the role of adenosine and adenosine receptor (AR) in the development and progression of DKD.…”