NaHS restores the vascular alterations in the renin-angiotensin system induced by hyperglycemia in rats

Silva‐Velasco, Diana L.; Beltrán-Ornelas, Jesús H.; Tapia-Martínez, Jorge; Sánchez-López, Araceli; Cruz, Saúl Huerta de la; Cervantes-Pérez, Luz Graciela; Valle-Mondragón, Leonardo Del; Sánchez-Mendoza, Alicia; Centurión, David

doi:10.1016/j.peptides.2023.171001

Cited by 2 publications

(1 citation statement)

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“…In a maternal renovascular hypertensive model, NaHS treatment also prevented the rise in BP in adult offspring, together with reducing the AT1R protein level [ 136 ]. Although the beneficial action of H 2 S has been linked to the activation of non-classic RAAS systems [ 139 ], no information currently exists regarding whether the reprogramming effect of H 2 S on renal programming is due to non-classic RAAS.…”

Section: Mechanisms Behind Protective Actions Of H 2 ...mentioning

confidence: 99%

Sulfur-Containing Amino Acids, Hydrogen Sulfide, and Sulfur Compounds on Kidney Health and Disease

et al. 2023

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Hydrogen sulfide (H2S) plays a decisive role in kidney health and disease. H2S can ben synthesized via enzymatic and non-enzymatic pathways, as well as gut microbial origins. Kidney disease can originate in early life induced by various maternal insults throughout the process, namely renal programming. Sulfur-containing amino acids and sulfate are essential in normal pregnancy and fetal development. Dysregulated H2S signaling behind renal programming is linked to deficient nitric oxide, oxidative stress, the aberrant renin–angiotensin–aldosterone system, and gut microbiota dysbiosis. In animal models of renal programming, treatment with sulfur-containing amino acids, N-acetylcysteine, H2S donors, and organosulfur compounds during gestation and lactation could improve offspring’s renal outcomes. In this review, we summarize current knowledge regarding sulfide/sulfate implicated in pregnancy and kidney development, current evidence supporting the interactions between H2S signaling and underlying mechanisms of renal programming, and recent advances in the beneficial actions of sulfide-related interventions on the prevention of kidney disease. Modifying H2S signaling is the novel therapeutic and preventive approach to reduce the global burden of kidney disease; however, more work is required to translate this into clinical practice.

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Section: Mechanisms Behind Protective Actions Of H 2 ...mentioning

confidence: 99%