Nailfold capillaroscopy by digital microscope in an Indian population with systemic sclerosis

Bhakuni, D. S.; Vasdev, Vivek; Garg, MK; Narayanan, K; Jain, Rahul; Mullick, Gautam

doi:10.1111/j.1756-185x.2011.01699.x

Cited by 30 publications

(17 citation statements)

References 23 publications

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“…However, our multivariate analysis retained only absence of sclerosis and telangiectasia as being significantly associated with normal/nonspecific NVC. These results are consistent with those previously reported that showed NVC severity to be associated with cutaneous sclerosis extent and significantly associated with SSc subsets [6,19,30]. Indeed, although early and active abnormal NVC patterns have more frequently been described for lcSSc and the late NVC pattern for dcSSc and during active disease [5,6,29], the normal NVC pattern seems to be more frequent in lcSSc than dcSSc [18,19,20].…”

Section: Discussionsupporting

confidence: 82%

“…Moreover, the SSc-specific NVC pattern is accepted as an independent factor predictive of RP progression to SSc, with a higher odds ratio than for other connective tissue diseases [14,16]. At the same time, the percentages of SSc patients having normal/nonspecific NVC patterns varied between 4 and 20%, depending on patient recruitment [7,17,18,19]. In most of studies using the LeRoy and Medsger criteria, a normal NVC pattern was more common in patients with lcSSc than dcSSc and was observed in up to 38% of lcSSc patients [18,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, the percentages of SSc patients having normal/nonspecific NVC patterns varied between 4 and 20%, depending on patient recruitment [7,17,18,19]. In most of studies using the LeRoy and Medsger criteria, a normal NVC pattern was more common in patients with lcSSc than dcSSc and was observed in up to 38% of lcSSc patients [18,19,20]. In this study, we were not able to assess the frequency of normal/nonspecific NVC in other SSc patients because of missing data rendering them ineligible.…”

Section: Discussionmentioning

confidence: 99%

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Systemic Sclerosis with Normal or Nonspecific Nailfold Capillaroscopy

et al. 2014

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Background: In systemic sclerosis (SSc), a specific nailfold videocapillaroscopy (NVC) pattern is observed in 90% of cases and seems to be associated with severity and progression of the disease. Objective: To describe the characteristics of SSc patients with normal or nonspecific (normal/nonspecific) NVC. Methods: In a retrospective cohort study, clinical features and visceral involvements of 25 SSc cases with normal/nonspecific NVC were compared to 63 SSc controls with the SSc-specific NVC pattern. Results: Normal/nonspecific NVC versus SSc-specific NVC pattern was significantly associated with absence of skin sclerosis (32 vs. 6.3%, p = 0.004), absence of telangiectasia (47.8 vs. 17.3%, p = 0.006) and absence of sclerodactyly (60 vs. 25.4%, p = 0.002), and less frequent severe pulmonary involvement (26.3 vs. 58.2%, p = 0.017). Conclusion: Normal/nonspecific NVC in SSc patients appears to be associated with less severe skin involvement and less frequent severe pulmonary involvement.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Systemic Sclerosis with Normal or Nonspecific Nailfold Capillaroscopy

et al. 2014

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“…Sato et al [13] and Bhakuni et al [14] found that capillary loss was associated with higher skin scores as assessed by modified Rodnan skin scores. Also the significant loss of capillaries in diffuse cutaneous disease as compared to limited disease was observed by Bhakuni et al [14] and Ostojic et al [15] in their study. These studies showed, with the increasing skin thickness, the capillary density decreases and thus patients with diffuse cutaneous disease which has higher skin scores have more marked capillary loss.…”

Section: Nailfold Capillaroscopy and Correlation With Organ Involvementmentioning

confidence: 99%

Nailfold Capillaroscopy in Rheumatic Diseases

Patil¹,

Sood²

2020

Vascular Biology - Selection of Mechanisms and Clinical Applications

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Nailfold capillaroscopy (NFC) has developed into an indispensable tool for rheumatologists in the evaluation of rheumatic diseases. It offers various advantages in being rapid, noninvasive, and inexpensive. With NFC we are able to visualize the microcirculatory changes in the nail beds. These changes are key to the pathogenesis of connective tissue diseases such as systemic sclerosis. Hence NFC helps in early diagnosis of various connective tissue diseases. There is a lack of standardization in the techniques used and various capillary parameters studied, which could lead to variation in the reporting of the parameters studied. In this chapter we shall try to highlight the most common parameters studied in capillaroscopy and its utility in various connective tissue diseases.

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“…Architectural pattern: 6 descriptive classes: cuticilis, open, tortuous, crossed, bushy, and bizarre will be noted. Intra- and inter-observer variability/reliability of < 10% will be acceptable [ 27 ]. Echocardiography Assessment Equipment & Method …”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study

et al. 2018

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BackgroundNephrotic syndrome (NS) is characterized by dyslipidemia which is a well-known risk factor for atherogenesis. Atherosclerosis in childhood is mostly subclinical and endothelial dysfunction is known to precede this. Evidence for screening for endothelial dysfunction and cardiovascular risk factors and early identification of premature onset of atherosclerosis in childhood NS remains tenuous in the absence of well-designed prospective studies addressing cardiovascular comorbidity in NS. The objective of our study is to examine endothelial dysfunction and short-term cardiovascular outcomes in a carefully phenotyped cohort of patients with Nephrotic syndrome as compared to healthy controls.MethodsIn a multi-centric prospective cohort study, 70 Steroid Resistant NS (SRNS), 70 Steroid Sensitive (SSNS) patients along with 70 Healthy Controls are being recruited. After a baseline assessment of functional and structural status of heart (2D Echocardiography), arteries (Carotid Doppler and Intima Media Thickness measurements) and microcirculation [a combination of 2D Echocardiography, Laser Doppler Flowmetry (LDF) and Brachial Artery Flow mediated dilation (FMD) and Nail Fold Capillaroscopy (NFC)], the patients are being investigated for endothelial dysfunction. Venous blood sample (15 ml) is being collected for routine investigations and assay of biochemical endothelial markers through Flow Cytometry. The patients will be followed up at 12 months and 24 months after the recruitment to look for any change from baseline period.DiscussionThis study will able to provide a better understanding of the epidemiology of endothelial dysfunction and associated subclinical cardiovascular co-morbidity in childhood NS. Findings on characterization of prevalence of endothelial dysfunction and subclinical markers may be used to design future randomized controlled trials for evaluating the efficacy of preventive and therapeutic interventions in reducing the incidence of cardiovascular disease.

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Nailfold capillaroscopy by digital microscope in an Indian population with systemic sclerosis

Abstract: Nailfold capillaroscopy changes in SSc are related to disease subset and MRSS. NFC with digital microscope is a simplified, inexpensive, outpatient procedure with results comparable to previous studies.

Cited by 30 publications

References 23 publications

Systemic Sclerosis with Normal or Nonspecific Nailfold Capillaroscopy

Systemic Sclerosis with Normal or Nonspecific Nailfold Capillaroscopy

Nailfold Capillaroscopy in Rheumatic Diseases

Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study

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