Nailfold capillaroscopy in systemic lupus erythematosus: A systematic review and critical appraisal

Cutolo, Maurizio; Melsens, Karin; Wijnant, Sara; Ingegnoli, Francesca; Thevissen, Kristof; Keyser, Filip De; Decuman, Saskia; Müller‐Ladner, Ulf; Piette, Yves; Riccieri, Valeria; Ughi, Nicola; Vandecasteele, Els; Vanhaecke, Amber; Smith, Vanessa

doi:10.1016/j.autrev.2017.11.025

Cited by 105 publications

(89 citation statements)

References 56 publications

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“…ramifications and disorganization of the microvascular array) [1,2730]. These parameters are defined as previously reported and were categorized into scleroderma patterns as normal or non-specific abnormalities [15,17,27,31]. A semiquantitative rating scale was used to score each capillary abnormality, in accordance with previous studies (03 score for each parameter; see Table 1 for details) [15,32].…”

Section: Nailfold Videocapillaroscopy (Nvc)mentioning

confidence: 99%

Progression of nailfold capillaroscopic patterns and correlation with organ involvement in systemic sclerosis: a 12 year study

et al. 2019

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Objective The aim of this observational study was to investigate the evolution of scleroderma microangiopathy throughout different nailfold videocapillaroscopy (NVC) patterns (‘early’, ‘active’, ‘late’) as well as the prevalence of organ involvement in SSc patients during a 12-year follow-up. Methods Thirty-four SSc patients showing at baseline (first capillaroscopic analysis) the ‘early’ NVC pattern of microangiopathy were enrolled and followed for 12 years (s.d. 2). Complete NVC analysis and clinical and serological findings were collected. Patients were in a standard therapeutic care setting. Statistical analysis was carried out by non-parametric tests. Results After a 12-year follow-up, the ‘early’ NVC pattern changed from baseline in 76% of the patients. The NVC pattern was found to be ‘active’ in 9 patients (26%), ‘late’ in 13 (38%) and characterized by non-specific capillary abnormalities in 4 (12%). In the subgroup whose microangiopathy progressed from the ‘early’ to the ‘late’ NVC pattern, the median time of progression from the ‘early’ to the ‘active’ pattern was significantly shorter (11 months) when compared with patients who progressed from the ‘early’ to the ‘active’ NVC pattern (55 months) (P = 0.002). The median time of progression between NVC patterns was significantly shorter in SSc patients showing either a nucleolar ANA pattern or Scl70 autoantibodies (P = 0.048). Organ involvement was progressively greater in SSc patients with ‘early’, ‘active’ and ‘late’ NVC patterns, respectively. Conclusions This longitudinal study confirms over a 12-year follow-up the evolution of specific NVC patterns associated with the progressive severity of organ involvement in SSc patients in a standard clinical care setting.

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Section: Nailfold Videocapillaroscopy (Nvc)mentioning

confidence: 99%

Progression of nailfold capillaroscopic patterns and correlation with organ involvement in systemic sclerosis: a 12 year study

et al. 2019

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“…A systematic review was recently performed by a EULAR study group, in order to establish capillaroscopic parameters in SLE patients and its correlations with clinical and laboratory characteristics [30]. According to this study, SLE patients present more tortuous and abnormal capillaries than healthy controls, as well as more hemorrhages (Figure 11).…”

Section: Systemic Lupus Erythematosus (Sle)mentioning

confidence: 99%

The Impact of Nailfold Capillaroscopy in the Approach of Microcirculation

Bernardino¹,

Rodrigues²,

Lladò³

et al. 2020

Vascular Biology - Selection of Mechanisms and Clinical Applications

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Nailfold capillaroscopy (NFC) is a simple, validated, and noninvasive method to assess the microcirculation, through direct visualization of the capillaries. Main patterns are classified, according to Cutolo et al., as scleroderma, further divided into early, active, or late patterns, or nonscleroderma. NFC findings include dilated loops, tortuosities, meandering or bushy capillaries, hemorrhage, or architectural distortion. NFC use has been indicated for the evaluation of Raynaud's phenomenon (RP), once it permits the distinction between primary and secondary RP. NFC results accounts for diagnostic criteria of systemic sclerosis, but they can also be useful in staging other connective tissue autoimmune diseases, like systemic lupus erythematosus, inflammatory myositis, or vasculitis. The CSURI index uses NFC for prediction of digital ulcer relapse. Recent evidence revealed NFC can also be applied in systemic disorders with vascular involvement.

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“…In a recent systematic review, Cutolo et al have helped summarise the limited existing literature of NFC in systemic lupus erythematosus (SLE) [57]. Although differences in the prevalence of capillary abnormalities in patients with SLE compared to normal controls have been found (especially with increased capillary tortuosity, prominent venous plexus and elongated capillaries), these are usually subtle compared to the more marked findings in SSc and IIM.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

The Established and Evolving Role of Nailfold Capillaroscopy in Connective-Tissue Disease

Parker¹,

McGill²

2020

Connective Tissue Disease - Current State of the Art

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Nailfold capillaroscopy (NFC) is a low-cost, non-invasive, rapid, highly specific and reproducible investigation well established in the diagnosis of systemic sclerosis and related conditions. This chapter will detail the relevant underlying scientific principles that underpin the investigation, the methods for performing NFC, the range of abnormalities that can be present and the currently available classification criteria before moving on to discuss the various established and emerging applications as relevant to the connective tissue diseases. In addition to its role in the diagnosis of SSc, highlighted by its inclusion in the most recent ACR/EULAR consensus classification criteria, NFC has been shown to predict disease activity, many organ-specific complications such as digital ulcers, pulmonary hypertension and interstitial lung disease, and even mortality. It is emerging as a useful investigation in other CTDs characterised by microvasculopathy, such as in the idiopathic inflammatory myopathies and mixed connective tissue disease, as well as being studied as a serial investigation in patients to act as a potential biomarker and measure of treatment efficacy. NFC can contribute to the earlier identification of patients with CTDs with clinically important complications and if applied accurately, therefore, can help improve outcomes in these often challenging diseases.

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Nailfold capillaroscopy in systemic lupus erythematosus: A systematic review and critical appraisal

Cited by 105 publications

References 56 publications

Progression of nailfold capillaroscopic patterns and correlation with organ involvement in systemic sclerosis: a 12 year study

Progression of nailfold capillaroscopic patterns and correlation with organ involvement in systemic sclerosis: a 12 year study

The Impact of Nailfold Capillaroscopy in the Approach of Microcirculation

The Established and Evolving Role of Nailfold Capillaroscopy in Connective-Tissue Disease

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